The Role of Sodium Phenylbutyrate in Modifying the Methylome of Breast Cancer Cells

Sabit, Hussein; El-Garhy, Aya T.; El-Zawahry, Mokhtar M.

doi:10.14299/ijser.2016.10.007

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Cytosine Methylation1

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Cited by 2 publications

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“…On the other hand, many drugs have been designed to modulate the methylome of malignant cells as a way of treatment. In our laboratory, we investigated different kind of DNMT inhibitors such as procaine and cyclophosphamide in different cancer cells including breast, colon, liver, cervical, lung, and laryngeal cancer [61][62][63][64].…”

Section: Cytosine Methylationmentioning

confidence: 99%

Cancer Epigenetics: Shifting to More Deep Action

Sabit

Abdel-Ghany

Çevik

et al. 2019

NACS

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Cancer is a major health problem facing the entire human population. It affects almost every race, gender, or age in the social hierarchy. Many mechanisms have been proposed for the development of cancer; either genetic or epigenetic. Over the years, a cumulative body of research indicated that epigenetic mutations (epimutations) represent a chief player in the course of cancer, where it affects cell proliferation, cancer initiation, progression, apoptosis, and metastasis. In this minireview we highlight the main mechanisms of epigenetic-mediated cancer development with emphasis on the environmental pollution role in this arena.

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Section: Cytosine Methylationmentioning

confidence: 99%