2022
DOI: 10.3390/ijms23031254
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The Role of Sphingolipid Signaling in Oxidative Lung Injury and Pathogenesis of Bronchopulmonary Dysplasia

Abstract: Premature infants are born with developing lungs burdened by surfactant deficiency and a dearth of antioxidant defense systems. Survival rate of such infants has significantly improved due to advances in care involving mechanical ventilation and oxygen supplementation. However, a significant subset of such survivors develops the chronic lung disease, Bronchopulmonary dysplasia (BPD), characterized by enlarged, simplified alveoli and deformed airways. Among a host of factors contributing to the pathogenesis is … Show more

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Cited by 17 publications
(9 citation statements)
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“…We are able to detect an increase in ceramides in Paraquat-treated membranes, as all adducts increase their presence, whereas, with α-tocopherol pre-treatment, the unsaturated ceramides decrease with respect to their values in Paraquat treatment, or remain absent. These bioactive lipid adducts can participate in diverse signaling pathways themselves or by their hydrolyzation to sphingosine through ceramidase enzymes [ 51 ]. The increased levels observed in the membranes from the Paraquat-treated cells, with respect to the control, can act as second messengers in apoptosis pathways [ 52 , 53 ], increasing cell death, as it is observed in Figure 1 .…”
Section: Discussionmentioning
confidence: 99%
“…We are able to detect an increase in ceramides in Paraquat-treated membranes, as all adducts increase their presence, whereas, with α-tocopherol pre-treatment, the unsaturated ceramides decrease with respect to their values in Paraquat treatment, or remain absent. These bioactive lipid adducts can participate in diverse signaling pathways themselves or by their hydrolyzation to sphingosine through ceramidase enzymes [ 51 ]. The increased levels observed in the membranes from the Paraquat-treated cells, with respect to the control, can act as second messengers in apoptosis pathways [ 52 , 53 ], increasing cell death, as it is observed in Figure 1 .…”
Section: Discussionmentioning
confidence: 99%
“…BPD is a disease with complex pathogenesis causing inflammation, cell death, and changes to the extracellular matrix, which affect lung growth, function, immunity, alveolarization, and vascularization, and make it harder for the lungs to repair and grow back [21]. Depending on the several factors that lead to lung damage in the preterm, various abnormalities in the bronchi, epithelial surfaces, mesenchyme, and pulmonary vasculature are likely to have a role in an infant's classification as having BPD.…”
Section: Etiology Of Bronchopulmonary Dysplasiamentioning
confidence: 99%
“…Neonates with BPD suffer from high mortality, morbidity, and chronic lung disease. [18][19][20] BPD is characterized by impaired alveolarization and defective pulmonary angiogenesis. [21,22] Pulmonary development includes six stages: embryonic, glandular, tubular, saccular, alveolar, and microvascular maturation.…”
Section: Introductionmentioning
confidence: 99%