The role of spironolactone in the treatment of patients with refractory hypertension

Ouzan, J

doi:10.1016/s0895-7061(01)01337-1

Cited by 28 publications

(32 citation statements)

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“…Lane et al clearly demonstrated that spironolactone therapy reduced BP as add-on therapy, and these data are supported by prior observations in the literature [2][3][4]. Although the time-course of spironolactone effect is not available from these particular studies, an add-on effect with spironolactone typically occurs within a matter of weeks, persists for months, and is independent of ethnicity and urinary aldosterone excretion rate [2][3][4].…”

Section: Editor's Commentsmentioning

confidence: 67%

“…Although the time-course of spironolactone effect is not available from these particular studies, an add-on effect with spironolactone typically occurs within a matter of weeks, persists for months, and is independent of ethnicity and urinary aldosterone excretion rate [2][3][4]. However, because this particular study was an observational one, there were many confounding variables; for example, there was a tendency in this surveillance study not to have administered spironolactone to young males for fear of sexual dysfunction and gynecomastia.…”

Section: Editor's Commentsmentioning

confidence: 99%

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Spironolactone use in resistant hypertension

Carl

Sica²

2007

Current Science Inc

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Section: Editor's Commentsmentioning

confidence: 67%

Section: Editor's Commentsmentioning

confidence: 99%

Spironolactone use in resistant hypertension

Carl

Sica²

2007

Current Science Inc

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“…Two decades later, a report suggested that doses of spironolactone less than 100 mg daily may be effective as add-on therapy for the treatment of resistant hypertension [47]. In this study, patients whose blood pressure was uncontrolled on at least two antihypertensive medications were prescribed spironolactone 1 mg/kg daily.…”

Section: Aldosterone Antagonistsmentioning

confidence: 94%

The role of aldosterone in resistant hypertension: Implications for pathogenesis and therapy

Epstein¹,

Calhoun²

2007

Current Science Inc

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Resistant hypertension constitutes an increasingly common medical disorder. Although the exact incidence is not precisely known, estimates derived from recent outcome studies emphasize that resistant hypertension is much more common than previously thought. A major advance in our understanding of its pathogenesis and management is the recent recognition of the importance of aldosterone excess or autonomy as an important mechanism for drug resistance in hypertension. Recent studies of the effects of aldosterone on vascular smooth muscle have delineated several extra-renal mechanisms whereby aldosterone produces hypertension primarily by its direct vasoconstrictor effects and by altering vascular compliance. Consequently, aldosterone blockade constitutes an effective intervention for treating resistant hypertension.

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“…Several groups have shown that measurement of plasma renin, and treatment of low-renin hypertension with potassium-sparing diuretics, greatly improves the control of hypertension in resistant cases [26][27][28]. The main reason for measuring plasma renin and aldosterone is not the pursuit of surgically correctible hypertension but the guidance of medical therapy [29].…”

Section: Blood Pressure Controlmentioning

confidence: 99%

Intensive management of risk factors for accelerated atherosclerosis: the role of multiple interventions

Spence

2007

Curr Neurol Neurosci Rep

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Patients at high risk of vascular events can reduce their risk by 75% to 80% through a combination of lifestyle changes and medical therapy. These include smoking cessation, a Mediterranean diet, daily exercise, maintaining a fit weight, moderate consumption of alcohol, effective control of blood pressure and diabetes, intensive treatment with lipid-lowering drugs and antiplatelet agents, and perhaps treatment with vitamins to lower homocysteine. Much of this is achieved primarily by the patient; physicians need to become better at assisting their patients in making lifestyle changes. Effective control of treatment-resistant hypertension can be improved by individualizing medical therapy to the underlying cause, based on measurement of plasma renin and aldosterone. Measurement of carotid plaque may be useful by providing feedback on the success of therapy.

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The role of spironolactone in the treatment of patients with refractory hypertension

Cited by 28 publications

References 0 publications

Spironolactone use in resistant hypertension

Spironolactone use in resistant hypertension

The role of aldosterone in resistant hypertension: Implications for pathogenesis and therapy

Intensive management of risk factors for accelerated atherosclerosis: the role of multiple interventions

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