The role of staphylococcal superantigens in the pathogenesis of marginal keratitis

Jayamanne, D G R; Dayan, Margaret; Jenkins, David R.; Porter, R

doi:10.1038/eye.1997.165

Cited by 16 publications

(15 citation statements)

References 14 publications

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“…In cases of lid involvement, the patients develop blepharitis with ocular discomfort and in a few cases might develop marginal keratitis and peripheral corneal scarring [12][13][14].…”

Section: Discussionmentioning

confidence: 99%

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Keratopathy after ultraviolet B phototherapy

Komericki

Fellner

El-Shabrawi

et al. 2005

Wien Klin Wochenschr

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Atopic dermatitis is the most common chronic inflammatory skin disease among children in industrialized countries. The prevalence is recorded to be up to 20% in children. Phototherapy with ultraviolet B (UVB) is an effective form of treatment with a low complication rate. Here we report on a patient with atopic dermatitis who underwent UVB treatment to the facial area including the eyelids and who developed severe keratitis with facial erythema. The symptoms diminished within a few days under topical steroid treatment. Although phototherapy seems to be a safe treatment procedure for atopic dermatitis, patients undergoing UVB treatment should be informed about possible side effects if the eyes are not fully closed during treatment. The use of protective eye shields should be considered, since UVB might induce long-term corneal damage and early onset of cataract.

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“…In cases of lid involvement, the patients develop blepharitis with ocular discomfort and in a few cases might develop marginal keratitis and peripheral corneal scarring [12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…In a very few severe cases the cornea might be involved, resulting in recurrent blepharitis and keratoconjunctivitis with marginal corneal scarring [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Keratopathy after ultraviolet B phototherapy

Komericki

Fellner

El-Shabrawi

et al. 2005

Wien Klin Wochenschr

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“…Local corneal hypersensitivity to staphylococcal exotoxins is thought to be responsible for an enhanced cell‐mediated immunity to staphylococcal antigens seen in some patients with marginal keratitis 3,4 . However, other studies have looked into the pathogenic role of staphylococcal superantigens in this condition, and have found that these are not likely to have a pivotal role in its development, but that other factors may also be involved 4,5 . Treatment with topical corticosteroids and topical antibiotics is usually effective.…”

Section: Reportmentioning

confidence: 99%

“…3,4 However, other studies have looked into the pathogenic role of staphylococcal superantigens in this condition, and have found that these are not likely to have a pivotal role in its development, but that other factors may also be involved. 4,5 Treatment with topical corticosteroids and topical antibiotics is usually effective. Occasionally, systemic antibiotics may be indicated if the disease is recurrent or severe.…”

Section: Reportmentioning

confidence: 99%

Dissecting folliculitis of the scalp with marginal keratitis

Sivakumaran¹,

Meyer

Burrows³

2001

Clinical and Experimental Dermatology

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We describe a young man with dissecting folliculitis of the scalp, who subsequently developed marginal keratitis. We are unaware of any previous reports of this association. The aetiology of dissecting folliculitis is thought to relate to abnormal follicular occlusion with subsequent suppuration, although an infective process has never been established. Marginal keratitis is postulated, but not proven, to be caused by an enhanced immune response to Staphylococcus aureus antigens. We suggest that a similar abnormal response to infection may be important in these two conditions. This case also highlights ocular complications which may occur in patients with dissecting folliculitis.

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“…[1][2][3][4][5][6][7][8][9][10][11] Noninfectious etiologies have also been identified and include diffuse lamellar keratitis (DLK) 12 and staphylococcal marginal hypersensitivity (SMH). 13,14 Since Smith and Maloney 12 first reported DLK in 1998, characterization of this and other noninfectious forms of post-LASIK keratitis has improved. 15,16 The comprehensive review published by Chang et al 17 in 2004 represents increasing understanding of the infectious etiologies underlying post-LASIK keratitis.…”

mentioning

confidence: 98%

Infectious and noninfectious keratitis after laser in situ keratomileusis

Moshirfar¹,

Welling²,

Feiz³

et al. 2007

Journal of Cataract and Refractive Surgery

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The occurrence of post-LASIK keratitis was 2.66%, with DLK being the most common diagnosis overall. The occurrence of noninfectious keratitis (2.34%) was 7.5 times greater than the occurrence of infectious keratitis (0.31%). Adenoviral keratitis had the best visual outcomes overall, with all 18 patients achieving 20/20 BSCVA. In contrast, all 5 eyes with HSV keratitis lost 1 or 2 lines of BSCVA. Excluding adenoviral keratitis, infectious etiologies had significantly worse visual outcomes than noninfectious etiologies at the 20/40 and 20/20 levels (P = .0013 and P<.001, respectively).

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The role of staphylococcal superantigens in the pathogenesis of marginal keratitis

Abstract: SUMMARY

Cited by 16 publications

References 14 publications

Keratopathy after ultraviolet B phototherapy

Keratopathy after ultraviolet B phototherapy

Dissecting folliculitis of the scalp with marginal keratitis

Infectious and noninfectious keratitis after laser in situ keratomileusis

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