The role of striatal Gα q/11 protein in methamphetamine-induced behavioral sensitization in mice

Lee, Kwang-Wook; Kim, Kyungin; Kim, Hyoung‐Chun; Lee, Seok‐Yong; Jang, Choon‐Gon

doi:10.1016/j.bbr.2017.12.003

Cited by 4 publications

(3 citation statements)

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“…Later, GP‐2A was characterized and used as a selective G q inhibitor, showing to selectively inhibit M 1 muscarinic receptor‐promoted GTP hydrolysis by Gα q/11 , with no inhibition of M 2 muscarinic receptor‐promoted GTP hydrolysis by G i . Two studies have used GP‐2A as a pharmacological tool to investigate the G q ‐mediated signaling: Tanski et al examined the role of G q signaling in rat pulmonary vascular smooth muscle cell proliferation in vitro, and Lee et al investigated the role of striatal Gα q/11 protein in methamphetamine‐induced behavioral sensitization in mice …”

Section: Selective Gq Inhibitorsmentioning

confidence: 99%

“…G q protein: gray surface. Modified from Reher et al64 et al investigated the role of striatal Gα q/11 protein in methamphetamine-induced behavioral sensitization in mice 94. For academic purposes, GP-2A is now commercially available from several companies, including Enzo Life Science, NY (CAS number: 89430-38-6), and due to the relatively simple structures, GP-2A and analogs can be readily prepared by standard SPPS.…”

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confidence: 99%

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Recent achievements in developing selective G_q inhibitors

Zhang

Nielsen

Strømgaard

2019

Medicinal Research Reviews

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G proteins are key mediators of G protein‐coupled receptor (GPCR) signaling, facilitating a plethora of important physiological processes. The role of G proteins is much less understood than other aspects of GPCR function, which is largely due to the shortage of potent and selective G protein inhibitors. The natural cyclic depsipeptides YM‐254890 and FR900359 are two of the very few known selective inhibitors of the Gq subfamily, and are used as unique pharmacological tools in the study of G q‐mediated signaling. Moreover, a peptide‐based G protein antagonist‐2A (GP‐2A), a 27‐residue peptide (27mer(I860A)) derived from phospholipase C‐β3 (PLC‐β3), and the small molecule BIM‐46187 have also been characterized as selective G q inhibitors within the past 5 years. In this review, we highlight the recent development in chemical syntheses, characterization, and mechanism of action of these selective G q inhibitors. The development and application of G q‐selective inhibitors will expand our knowledge of the structure and function of G protein‐mediated signaling, shed light on the development of inhibitors for other G protein classes, and feed in to drug discovery for diseases where G proteins are implicated, including various forms of cancer.

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Section: Selective Gq Inhibitorsmentioning

confidence: 99%

mentioning

confidence: 99%

Recent achievements in developing selective G_q inhibitors

Zhang

Nielsen

Strømgaard

2019

Medicinal Research Reviews

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“…The mechanism of METH addiction has been studied intensively in the field of biomedicine. The neural circuits associated with METH addiction are very complex, involving multiple brain regions (Kai et al, ; Xu et al, ) and a multitude of neurotransmitters (Jiang et al, ; Jing, Liu, Zhang, & Liang, ) and protein mediators (Lee, Kim, Kim, Lee, & Jang, ; Mohd‐Yusof et al, ; Sun et al, ; Zhao et al, ). The incentive‐sensitization theory of addiction is one of the most widely accepted classical theories used to explain METH‐induced behavioral sensitization.…”

Section: Introductionmentioning

confidence: 99%

Involvement of dopamine D3 receptor and dopamine transporter in methamphetamine‐induced behavioral sensitization in tree shrews

Huang

Yang

et al. 2020

Brain and Behavior

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Introduction This study aims to establish a methamphetamine (METH)‐induced behavioral sensitization model using tree shrews, as well as to measure the protein expression of the dopamine D3 receptor (D3R) and dopamine transporter (DAT). Methods Forty tree shrews were equally and randomly divided into four experimental groups: those administered with 1, 2, and 4 mg/kg METH and a control group (treated with an equal amount of normal saline). Each experimental group was repeatedly exposed to METH for nine consecutive days to induce the development of behavioral sensitization, followed by four days of withdrawal (without the METH treatment) to induce the transfer of behavioral sensitization, then given 0.5 mg/kg of METH to undergo the expression of behavioral sensitization. Altered locomotor and stereotypic behaviors were measured daily via open‐field experiments during the development and expression stages, and weight changes were also recorded. Then, the Western blot method was used to detect the expression levels of D3R and DAT in three brain regions: the nucleus accumbens, prefrontal cortex, and dorsal striatum 24 hr after the last behavioral test. Results METH administration augmented motor‐stimulant responses and stereotypic behaviors in all experimental groups, and stereotypic behaviors intensified more in the groups treated with 2 and 4 mg/kg METH. Motion distance, speed, and trajectory were significantly elevated in all experimental, however, METH at 4 mg/kg induced more stereotypic behaviors, decreasing these locomotor activities as compared with the 2 mg/kg METH group. 2 and 4 mg/kg METH significantly upregulated and downregulated D3R and DAT expression levels, respectively, in three brain regions, and these changes are more pronounced in 2 mg/kg METH. Conclusions These results indicated that this animal model may be used to study the neurobiological mechanisms that underly the development and expression of behavioral sensitization to METH. Deregulated D3R and DAT expression may be involved in the METH‐induced behavioral sensitization.

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Fas and GIT1 signalling in the prefrontal cortex mediate behavioural sensitization to methamphetamine in mice

Shao

Liu

Wei

et al. 2020

Brain Research Bulletin

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The role of striatal Gα q/11 protein in methamphetamine-induced behavioral sensitization in mice

Cited by 4 publications

References 54 publications

Recent achievements in developing selective G_q inhibitors

Recent achievements in developing selective G_q inhibitors

Involvement of dopamine D3 receptor and dopamine transporter in methamphetamine‐induced behavioral sensitization in tree shrews

Fas and GIT1 signalling in the prefrontal cortex mediate behavioural sensitization to methamphetamine in mice

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The role of striatal Gα q/11 protein in methamphetamine-induced behavioral sensitization in mice

Cited by 4 publications

References 54 publications

Recent achievements in developing selective Gq inhibitors

Recent achievements in developing selective Gq inhibitors

Involvement of dopamine D3 receptor and dopamine transporter in methamphetamine‐induced behavioral sensitization in tree shrews

Fas and GIT1 signalling in the prefrontal cortex mediate behavioural sensitization to methamphetamine in mice

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Product

Resources

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Recent achievements in developing selective G_q inhibitors

Recent achievements in developing selective G_q inhibitors