The Role of Substance P in the Pathogenesis of Pterygia

Chui, Jeanie; Girolamo, Nick Di; Coroneo, Minas T.; Wakefield, Denis

doi:10.1167/iovs.07-0123

Cited by 39 publications

(30 citation statements)

References 53 publications

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“…Stapleton and 8,15 . Indirect evidence of this interesting argument was reported by Chui and coworkers 16 . The authors found elevated presence of substance P preferred receptor in pterygia and demonstrated that this neuropeptide could contribute to the lesion shape though its profibrogenic and angiogenic action.…”

Section: Discussionmentioning

confidence: 78%

Determining Factors for Fast Corneal Sensitivity Recovery After Pterygium Excision

Julio

Campos

Pujol

et al. 2016

Cornea

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Purpose: To establish determining factors for fast corneal sensitivity (CS) recovery after pterygium excision.Methods: Thirty-two eyes of 14 males and 18 females with primary nasal pterygium were recruited. Differences in CS (in the four quadrants and the center using Cochet-Bonnet esthesiometer), pterygium corneal area (PCA), tear osmolarity, tear break up time, Schirmer test, and ocular symptoms were analyzed before and 1 month after lesion excision. The relationship between CS recovery (difference between the two time points; CS1-CS0) and the other features was assessed.Results: All the studied locations exhibited normal (6 cm) or near normal mean CS at the 2 time points, except tendency for moderate hypoesthesia in nasal CS0 (median 4.5; range: 1.5 -6.0 cm). Point by point comparison revealed significant postoperative improve in nasal location (p=0.008; Wilcoxon rang test) with normal values in 17 eyes (53%) and a median CS1= 5.0 cm (2.5 -5.5 cm) in 15 eyes with no complete recovery. No significant correlation was found between CS0 and the studied variables and CS1 was only significantly correlated with PCA (rho: -0.441; p<0.05). CS recovery also showed significant correlation with PCA (rho= -0.516; p<0.01). Conclusions:Corneal sensitivity recovery after pterygium excision showed important variability and the only studied factor that seems to be determinant could be PCA. It would be advisable to operate while lesion is relatively small, with lower surgical injury, and faster and complete recovery, thus protecting ocular surface homeostasis.3

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Section: Discussionmentioning

confidence: 78%

Determining Factors for Fast Corneal Sensitivity Recovery After Pterygium Excision

Julio

Campos

Pujol

et al. 2016

Cornea

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“…139 Inflammation is known to induce angiogenic pathways, which could result in neovascularization and contribute to pterygium growth. The angiogenic stimulation found in pterygium seems to be related to elevated levels of VEGF, low levels of thrombodopsin-1 (Tsp-1), 2 and a decrease in substance P, 140 which all promote the activity of the ETS-1 transcription factor that directly induces angiogenic activity. 25 VEGF acts as a chemokine in the initial step of basement membrane degradation during angiogenesis, which is a requisite process for the further locomotion and proliferation of endothelial cells, so they finally develop tubule-like structures.…”

Section: Angiogenesis and Lymphangiogenesismentioning

confidence: 99%

Molecular Basis of Pterygium Development

Cárdenas-Cantú

Zavala

Valenzuela

et al. 2014

Seminars in Ophthalmology

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Pterygium pathogenesis is mainly related to UV light exposure. However, the exact mechanisms by which it is formed have not been elucidated. Clinical advances in surgical treatment use conjunctival autografts and amniotic membranes in combination with adjuvant therapies, including mitomycin C, β-radiation, and 5-fluoroacil, to reduce recurrence. Several studies aim to unveil the molecular mechanisms underlying pterygium growth and proliferation. They demonstrate the role of different factors, such as viruses, oxidative stress, DNA methylation, apoptotic and oncogenic proteins, loss of heterozygosity, microsatellite instability, inflammatory mediators, extracellular matrix modulators, lymphangiogenesis, cell epithelial-mesenchymal transition, and alterations in cholesterol metabolism in pterygium development. Understanding the molecular basis of pterygium provides new potential therapeutic targets for its prevention and elimination. This review focuses on providing a broad overview of what is currently known regarding molecular mechanisms of pterygium pathogenesis.

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“…47 Furthermore, limbal focusing may also affect corneal nerves as they cross the limbus, allowing the possibility of neuropeptide involvement in pterygium pathogenesis and explaining corneal sensory alterations in pterygium patients. 48 If corneal nerves are implicated, their radial distribution may also help to explain pterygium shape.…”

Section: Peripheral Light Focusing and Pterygium Pathogenesismentioning

confidence: 99%

“…79 Another potential mode of action of cyclosporine is by the inhibition of the tachykinin NK1 receptors 80 that we have localized to infiltrating fibroblasts, mononuclear cells and the epithelia of pterygia. 48 In general terms, exposure of cells to UV induces activation of epidermal growth factor receptors (EGFRs) and subsequent downstream signaling through the mitogen-activated protein kinase pathways 65,66,81 that are partially responsible for expression of proinflammatory cytokines, and matrix metalloproteinases in pterygium cells. Growth factor receptors and associated signaling pathways are activated as an early response to UV exposure, occurring independently of ligand binding and believed to involve UVgenerated reactive oxygen species.…”

Section: Peripheral Light Focusing and Pterygium Pathogenesismentioning

confidence: 99%

Ultraviolet Radiation and the Anterior Eye

Coroneo

2011

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

116

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The eye is on the one hand dependent on visible light energy and on the other hand can be damaged by these and the contiguous ultraviolet (UV) and infrared wavelengths. Diseases of the eye in which sunlight has been implicated have been termed the ophthalmohelioses, and these conditions pose a significant problem to the eye health of many communities. The ophthalmohelioses have a tremendous impact on patients' quality of life and have significant implications on the cost of health care. Although cataract is not entirely caused by insolation, it now seems certain that sunlight plays a contributory role-cataract extraction is one of the, if not the most, commonly performed surgical procedures in many societies. Pterygium, typically afflicting a younger population, adds a tremendous burden, both human and financial, in many countries. We review evidence that peripheral light focusing by the anterior eye to the sites of usual locations of pterygium and cataract plays a role in the pathogenesis of these conditions. Recognition of the light pathways involved with foci at stem cell niches has directed our investigations into inflammatory and matrix metalloproteinase-related pathophysiologic mechanisms. An understanding of the intracellular mechanisms involved has provided some insight into how medical treatments have been developed for the effective management of ocular surface squamous neoplasia. The concept of peripheral light focusing has also provided direction in the prevention of these diseases. This has resulted in improved sunglass design and the further development of UV-blocking contact lenses. With the development of ocular UV fluorescence photographic techniques, we have been able to demonstrate preclinical ocular surface evidence of solar damage. Evidence that diet may play a role in the development of certain conditions is reviewed. The conundrum of the public health message about solar exposure is also reviewed, and in this context, the potential role of vitamin D deficiency is summarized. The eye may play a role in the development of individualized assessment techniques of solar damage, perhaps allowing us to provide better advice to both individuals and populations.

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The Role of Substance P in the Pathogenesis of Pterygia

Abstract: For the first time, this study showed the presence of NK(1) receptor in pterygia and that SP is a potent chemoattractant for pterygium fibroblasts and vascular endothelial cells, implying that SP may contribute to the shape of pterygia through its profibrogenic and angiogenic action.

Cited by 39 publications

References 53 publications

Determining Factors for Fast Corneal Sensitivity Recovery After Pterygium Excision

Determining Factors for Fast Corneal Sensitivity Recovery After Pterygium Excision

Molecular Basis of Pterygium Development

Ultraviolet Radiation and the Anterior Eye

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