2023
DOI: 10.1002/lary.30628
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The Role of Substance P Receptor Antagonists in Allergic Rhinitis: Ovalbumin‐Induced Rat Model

Abstract: ObjectiveSubstance P is a peptide from the tachykinin family, which is found in peripheral and central nervous systems, causing vasodilation and increased secretion in the nasal mucosa. In this study, we aimed to investigate whether the experimental model of allergic rhinitis will cause allergic changes in the larynx and to compare the effects of aprepitant, a substance P antagonist, on nasal symptoms in allergic rhinitis, and histopathological changes in the nasal and laryngeal mucosa with antihistamine and l… Show more

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