The Role of<sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography in the Treatment of Brain Abscess

Park, Seong‐Hyun; Lee, Sang‐Woo; Kang, Donghoon; Hwang, Jeong-In; Sung, Joo-Kyung; Hwang, Sung-Kyoo

doi:10.3340/jkns.2011.49.5.278

Cited by 12 publications

(4 citation statements)

References 18 publications

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“…In contrast, our study revealed that only gender was a critical factor influencing outcome. As far as therapeutic effect is concerned, Park SH et al demonstrated that MRI plus FDG-PET improved the accuracy of assessing therapeutic responses to antibiotics treatment of brain abscess and aided in optimizing therapy [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

A retrospective study on the aetiology, management, and outcome of brain abscess in an 11-year, single-centre study from China

Zhang

et al. 2014

BMC Infect Dis

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BackgroundBrain abscesses continue to pose diagnostic and therapeutic challenges in developed and developing countries. Their aetiology and management remain complex and unclear, making improvement of treatments and outcome difficult.MethodsTo determine the demographics, management, and the variables that affect the outcome in subjects with brain abscesses treated at a single centre over an 11-year period, we retrospectively analysed data in 60 patients with brain abscesses surgically treated with stereotactically guided aspiration or open craniotomy excision in Shanghai Changzheng Hospital between January 2001 and December 2011. Such variables as age, gender, Glasgow Coma Scale (GCS) score at admission, clinical presentation, location, number of lesions, predisposing factors, mechanism of infection, aetiological agent, and therapy were analysed independently.ResultsOur analysis demonstrated that patient age and gender were factors that influence the occurrence of brain abscess; female patients and patients greater than 40 years of age were most likely to suffer a brain abscess. We also found that a patient’s GCS score upon admission did not influence outcome. While frequency of successful culturing of the infectious agent was low, positive cultures were obtained in only 8 of the cases (13.33%), in which the most common isolate was Streptococcus milleri. Outcome was favourable in 78.33% of the subjects, while the mortality rate was 20%. The outcome of one patient was poor due to the abscess in the basal ganglia region.ConclusionsStereotactically guided aspiration is an effective treatment for brain abscess with an overall favourable outcome. Mortality due to brain abscess was not directly related to surgery nor surgical technique. Additional studies will continue to reveal patients trends that may improve treatment for brain abscess.

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Section: Resultsmentioning

confidence: 99%

A retrospective study on the aetiology, management, and outcome of brain abscess in an 11-year, single-centre study from China

Zhang

et al. 2014

BMC Infect Dis

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“…The mortality rate associated with brain abscesses was reported to be as high as 40% in the 1980s 8) . Advances in radiographic scanning, the development of novel surgical techniques, and the availability of newer antibiotics have all helped decrease the mortality rate in patients with brain abscesses 6 , 24 , 26 , 34) . Recently, Tseng and Tseng 31) have published the clinical outcomes of their patients with brain abscesses (n=142), of which 16.9% died during hospitalization.…”

Section: Discussionmentioning

confidence: 99%

“…In the past, brain abscesses were a uniformly fatal condition. However, the introduction of computed tomography (CT) in the early 1970s and the development of neurosurgical techniques along with the use of broad-spectrum antibiotics contributed to an improvement in patient prognoses 6 , 24 , 26 , 34) . The purpose of this study was to review the data of 51 patients with brain abscesses admitted to a single tertiary referral hospital during a recent 10-year period and describe their clinical characteristics, outcome of treatment, and prognostic factors.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors Associated with Poor Outcomes in Patients with Brain Abscesses

Park

et al. 2014

J Korean Neurosurg Soc

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ObjectiveThe purpose of this study was to describe the clinical characteristics, treatment outcomes, and prognostic factors in patients with brain abscesses treated in a single institute during a recent 10-year period.MethodsFifty-one patients with brain abscesses who underwent navigation-assisted abscess aspiration with antibiotic treatment were included in this study. Variable parameters were collected from the patients' medical records and radiological data. A comparison was made between patients with favorable [Glasgow Outcome Scale (GOS) ≥4] and unfavorable (GOS <4) outcomes at discharge. Additionally, we investigated the factors influencing the duration of antibiotic administration.ResultsThe study included 41 male and 10 female patients with a mean age of 53 years. At admission, 42 patients (82%) showed either clear or mildly disturbed consciousness (GCS ≥13) and 24 patients (47%) had predisposing factors. The offending microorganisms were identified in 25 patients (49%), and Streptococcus species were the most commonly isolated bacteria (27%). The mean duration of antibiotic administration was 42 days. At discharge, 41 patients had a favorable outcome and 10 had an unfavorable outcome including 8 deaths. The decreased level of consciousness (GCS <13) on admission was likely associated with an unfavorable outcome (p=0.052), and initial hyperglycemia (≥140 mg/dL) was an independent risk factor for prolonged antibiotic therapy (p=0.032).ConclusionWe found that the level of consciousness at admission was associated with treatment outcomes in patients with brain abscesses. Furthermore, initial hyperglycemia was closely related to the long-term use of antibiotic agents.

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“…Radiographic abnormalities may persist for months after successful therapy, making useless the CT scan control before three weeks of intravenous antibiotic therapy (9). Moreover, Park et al demonstrated that MRI plus FDG-PET im-proved the accuracy of assessing therapeutic responses to antibiotics treatment of brain abscess and aided in optimizing therapy (20).…”

Section: Discussionmentioning

confidence: 99%

Pyogenic Brain Abscess in Children: A Tunisian Multi-Centric Experience

Tfifha

Abdallah

Saadaoui

et al. 2018

Arch Pediatr Infect Dis

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Background: Brain Abscess (BA) is an uncommon intracranial suppurative infectious disease, especially in children. Its treatment involves surgery and prolonged antibiotics courses. Objectives: The current study aimed at describing the clinical characteristics of children with BA, treated at the central Tunisian region health center. Methods: A retrospective study, lasting 19 years (1995 to 2014), was conducted in four Tunisia pediatric departments of the central region. Forty-one children having radiological abnormalities suggestive of BA and confirmed operative lesions were included. Mycobacterial, parasitic or fungal abscesses were excluded. Medical records were analyzed for age, gender, presenting symptoms, predisposing factors, imaging, microbiology findings, treatment, and outcome. Results: The mean age was 4.9 years (range: 4 days to 16 years). The most common clinical presentations were increased intracranial pressure symptoms (87%). Brain Abscess was diagnosed in 95.1% on the basis of cranial imaging. The majority of abscesses were supratentorial (92.6%). The most frequent etiology was contiguous infections of the skull (63.4%). No predisposing factor was found in 17%. Intravenous antibiotics were given in all cases with surgical drainage in 63.4%, causative organisms were identified in 53.7%; gram positive cocci in 21.9%, and gram negative cocci in 9.7%. The mortality rate was 24.3%. Age of less than two years was the only statistically significant identified prognostic factor. Conclusions: The current study confirmed the severity of this pathology and underlined the importance of early diagnosis and management.

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The Role of¹⁸F-Fluorodeoxyglucose Positron Emission Tomography in the Treatment of Brain Abscess

Cited by 12 publications

References 18 publications

A retrospective study on the aetiology, management, and outcome of brain abscess in an 11-year, single-centre study from China

A retrospective study on the aetiology, management, and outcome of brain abscess in an 11-year, single-centre study from China

Risk Factors Associated with Poor Outcomes in Patients with Brain Abscesses

Pyogenic Brain Abscess in Children: A Tunisian Multi-Centric Experience

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The Role of18F-Fluorodeoxyglucose Positron Emission Tomography in the Treatment of Brain Abscess

Cited by 12 publications

References 18 publications

A retrospective study on the aetiology, management, and outcome of brain abscess in an 11-year, single-centre study from China

A retrospective study on the aetiology, management, and outcome of brain abscess in an 11-year, single-centre study from China

Risk Factors Associated with Poor Outcomes in Patients with Brain Abscesses

Pyogenic Brain Abscess in Children: A Tunisian Multi-Centric Experience

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The Role of¹⁸F-Fluorodeoxyglucose Positron Emission Tomography in the Treatment of Brain Abscess