The role of surfaces in catheter-associated infections

Noimark, Sacha; Dunnill, Charles W.; Wilson, Michael; Parkin, Ivan P.

doi:10.1039/b908260c

Cited by 200 publications

(178 citation statements)

References 126 publications

(270 reference statements)

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“…More effective antibacterial films are needed at present due to the increasing resistance of pathogenic bacteria to synthetic antibiotics when administered for long times [2]. Recently, Mills et al [3], Parkin et al [4][5][6][7], Foster et al [8], Dunlop et al [9] and Yates et al [10] have reported antibacterial films of Ag and Cu films on glass and thin polymer films by chemical vapor deposition (CVD) and in some cases sputtering techniques.…”

Section: Introductionmentioning

confidence: 99%

Coupling of narrow and wide band-gap semiconductors on uniform films active in bacterial disinfection under low intensity visible light: Implications of the interfacial charge transfer (IFCT)

Rtimi

Sanjinés

Pulgarín

et al. 2013

Journal of Hazardous Materials

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Section: Introductionmentioning

confidence: 99%

Coupling of narrow and wide band-gap semiconductors on uniform films active in bacterial disinfection under low intensity visible light: Implications of the interfacial charge transfer (IFCT)

Rtimi

Sanjinés

Pulgarín

et al. 2013

Journal of Hazardous Materials

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“…Also nosocomial infections due to antibiotic resistant bacteria are becoming more frequent developing into a serious problem associated with high health care costs. Recently, Mills et al [6], Parkin et al [7][8][9][10], Foster et al [11], Dunlop et al [12] and Yates et al [13] have reported antibacterial Ag, Cu, and TiO 2 coatings on glass and polymer films depositing the metal/oxides by CVD and sputtering techniques. Our laboratory has reported the antibacterial properties and kinetics of Ag-and Cu-modified textiles deposited by DC-magnetron, pulsed DC-magnetron and high power impulse magnetron sputtering (HIPIMS).…”

Section: Introductionmentioning

confidence: 99%

ZrNO–Ag co-sputtered surfaces leading to E. coli inactivation under actinic light: Evidence for the oligodynamic effect

Rtimi

Pascu

Sanjinés

et al. 2013

Applied Catalysis B: Environmental

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a b s t r a c tThis study reports visible light sensitive ZrNO and ZrNO-Ag polyester samples prepared by sputtering in an Ar/N 2 /O 2 atmosphere leading to Escherichia coli bacterial inactivation. The bacterial inactivation by ZrNO avoids the increasing environmental concern involving the fate of Ag-leaching of many disinfectants. The simultaneous co-sputtering of ZrNO and Ag 2 O enhanced the E. coli bacterial inactivation kinetics compared to the sequential sputtering of ZrNO and Ag. A reaction mechanism is suggested triggered by photoinduced interfacial charge transfer (IFCT) suggesting electron injection form the Ag 2 O cb to the ZrO 2cb . The sizes of the ZrO 2 and Ag nanoparticles in the co-sputtered ZrNO-Ag were 80-130 nm and 8-15 nm respectively as determined by high angular annular dark field (HAADF) microscopy. Evidence is presented by X-ray photoelectron spectroscopy (XPS) for the self-cleaning of the photocatalysts after bacterial inactivation. This enabled a stable catalyst reuse. The XPS experimental spectra of ZrNO and ZrNO-Ag were deconvoluted into their ZrN, ZrNO and ZrO 2 components. The amounts of Ag-ions released during bacterial inactivation were < 5 ppb/cm 2 and well below the Ag cytotoxic levels. Since no cytotoxicity was introduced during the bacterial inactivation process, the ZrNO-Ag disinfection proceeds through an oligodynamic effect.

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“…To control the ion release, focus has shifted from bulk silver to nanoscale coatings and doped solids or hydrogels, with impregnated catheters and wound dressings already in clinical use [3,4,22,23]. With the use of silver nanoparticles (Ag NPs) for example, a higher surface area will increase the Ag + release.…”

Section: Introductionmentioning

confidence: 99%

Reactive combinatorial synthesis and characterization of a gradient Ag–Ti oxide thin film with antibacterial properties

et al. 2015

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Growing demand for orthopedic and dental implants has spurred researchers to develop multifunctional coatings, combining tissue integration with antibacterial features. A possible strategy to endow titanium (Ti) with antibacterial properties is by incorporating silver (Ag), but designing a structure with adequate Ag + release while maintaining biocompatibility has been shown difficult. To further explore the composition-structure-property relationships between Ag and Ti, and its effects against bacteria, this study utilized a combinatorial approach to manufacture and test a single sample containing a binary Ag-Ti oxide gradient. The sample, sputter deposited in a reactive (O 2 ) environment using a custom built combinatorial physical vapor deposition (PVD) system, was shown to be effective against Staphylococcus aureus with viability reductions ranging from 17 to above 99 %, depending on amount of Ag + released from its different parts. The Ag content along the gradient ranged from 35 to 62 wt%, but it was found that structural properties such as varied porosity and degree of crystallinity, rather than amount of incorporated Ag governed the Ag + release and resulting antibacterial activity. The coating also demonstrated in vitro apatite forming abilities, where structural variety along the sample was shown to alter the hydrophilic behavior, with degree of hydroxyapatite (HA) deposition varying accordingly. By means of combinatorial synthesis, a single gradient sample was able to display intricate compositional and structural features affecting its biological response, which would otherwise require a series of coatings. The current findings suggest that future implant coatings incorporating Ag as an antibacterial agent could be structurally enhanced to better suit clinical requirements.

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The role of surfaces in catheter-associated infections

Cited by 200 publications

References 126 publications

Coupling of narrow and wide band-gap semiconductors on uniform films active in bacterial disinfection under low intensity visible light: Implications of the interfacial charge transfer (IFCT)

Coupling of narrow and wide band-gap semiconductors on uniform films active in bacterial disinfection under low intensity visible light: Implications of the interfacial charge transfer (IFCT)

ZrNO–Ag co-sputtered surfaces leading to E. coli inactivation under actinic light: Evidence for the oligodynamic effect

Reactive combinatorial synthesis and characterization of a gradient Ag–Ti oxide thin film with antibacterial properties

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