The Role of Surgery in the Treatment of Clinically Isolated Adrenal Metastasis

Adrenalectomy Improves Outcomes of Selected Patients with Metastatic Carcinoma

“…In 1997, the Memorial Sloan Kettering Cancer Center reported their experience with 37 patients over a 10-year period. In all, 73% of whom were asymptomatic upon presentation [11]. All nine patients presenting with pain had symptomatic relief after surgery [11].…”

“…Despite small series reporting improved survival [8][9][10][11][12] among those with metastatic melanoma, renal cell carcinoma, and lung cancer, among others, the indications for adrenalectomy (ADX) in the setting of metastatic cancer have not been clearly defined. The lack of randomized controlled trials represents the biggest challenge to developing treatment guidelines for this specific subset of patients.…”

Stereotactic Body Radiation Therapy (SBRT) for treatment of adrenal gland metastases from non-small cell lung cancer

“…In symptomatic patients, suffering from back pain, palliative irradiation may be a treatment option, but published clinical data are rare [22,24,33]. Soffen [24] reported on 16 lung cancer patients, who had local irradiation from 29.25 Gy Table 2 Published surgical data could demonstrate good survival rates after resection of an isolated metastasis of the adrenal gland [12,17,21]. Kim [12] published first a retrospective analysis from 37 patients, who had undergone adrenalectomy between July 1986 and October 1996.…”

“…Soffen [24] reported on 16 lung cancer patients, who had local irradiation from 29.25 Gy Table 2 Published surgical data could demonstrate good survival rates after resection of an isolated metastasis of the adrenal gland [12,17,21]. Kim [12] published first a retrospective analysis from 37 patients, who had undergone adrenalectomy between July 1986 and October 1996. Sarela [21] updated these results and demonstrated a median PFS of 11 months and an actuarial PFS and OS of 21% and 24% after 5 years, respectively.…”

Stereotactic Body Radiation Therapy (SBRT) for adrenal metastases

“…When detected, radiation therapy is generally adopted in case of palliative treatments aiming to pain control [15,16,20,23,24,31,33]. Stereotactic body radiation therapy (SBRT) allows patients with solitary or oligometastases (less than five) to be treated.…”