The role of surgery in anaplastic thyroid cancer: A systematic review

Hu, Shirley; Helman, Samuel N.; Hanly, Elyse K.; Likhterov, Ilya

doi:10.1016/j.amjoto.2017.02.005

Cited by 45 publications

(41 citation statements)

References 41 publications

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“…Anaplastic thyroid cancer is an extremely hostile type of thyroid cancer that has a median survival rate of only 4 months. It is present most commonly as an enlarged neck mass, which is often diagnosed at an advanced stage (Hu et al 2017). Under a light microscope multinucleated cells with large abnormal nuclei can be observed without any of features of thyroid differentiation (O'Neill & Shaha, 2013).…”

Section: Anaplastic Thyroid Cancer (Atc)mentioning

confidence: 99%

Expressional Analysis of Vascular Endothelial Growth Factor A (VEGFA) in Patients with Thyroid Cancer

Azhar¹

2018

Preprint

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Carcinogenesis of cells in the tissues of the thyroid gland leads to formation of thyroid cancer. Development of thyroid cancer involves a multifactorial route that is associated with various risk factors, such as exposure to ionizing radiation in early life, genetic predisposition, iodine intake in diet, environmental carcinogens, and genetic instability etc. These different risk factors can lead to a variety of mutations within proto-oncogenes and activating them as oncogenes. VEGF-A is one such proto-oncogene that plays a key role in tumour angiogenesis. The purpose of this study was to explore the association of respective gene with thyroid cancer pathogenesis. To test the hypothesis that VEGF-A expression patterns has influence in thyroid cancer metastasis and sustenance, a population based case-control study was conducted in 77 thyroid tumour samples along with adjacent control tissue samples. Quantitative real time-PCR (qPCR) was used for mRNA expression variation in VEGF-A gene. Expression analysis showed that VEGF-A expression level was very highly significantly downregulated (p<0.001) in tissues of thyroid cancer compared to adjacent control tissues. Non-significant (p>0.05) increase of VEGF-A expression mRNA with age group, gender, and advanced stages of T, N, and M stages was also observed in thyroid cancer samples compared to the controls. However, when compared for the expression levels relative to the proliferation marker, Ki67, very highly significant upregulation in thyroid tumour samples was seen in the same study cohort. Based on these results we can conclude that VEGF-A under expression at transcriptional level may be playing a key role in progression and/or spread of thyroid cancer.

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Section: Anaplastic Thyroid Cancer (Atc)mentioning

confidence: 99%

Expressional Analysis of Vascular Endothelial Growth Factor A (VEGFA) in Patients with Thyroid Cancer

Azhar¹

2018

Preprint

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“…Due to the rapid rise in incidence of thyroid cancer, it is now recognized as a major public health problem globally. [ 1 – 3 ] It is the most familiar kind of endocrine malignancy and it causes more deaths than all other endocrine cancers combined. In the United States, from 1975 to 2009, the annual incidence increased from 14.9 per 100,000 to 14.3 per 100,000, almost tripling.…”

Section: Introductionmentioning

confidence: 99%

Psychological nursing intervention reduces psychological distress in patients with thyroid cancer

Zou²

2020

Medicine

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Background: Thyroidectomy has been considered an effective method to treat thyroid cancer. However, about 20% of patients have psychological distress before surgery. Psychological distress is considered common mental illnesses and it has been reported that the patients who suffer psychological distress have poor clinical outcomes than the patients without psychosocial disorder. Therefore, we design this randomized controlled study to explore the effect of psychological nursing intervention against quality of life and psychological distress of the patients with thyroid cancer. Method: The trial will be conducted from September 2020 to December 2020 at Wuhan Fourth Hospital on the basis of the International Council for Harmonisation's Good Clinical Practice Guidelines and the principles of the Helsinki Declaration. The study was authorized via the Research Ethics Committee of the Wuhan Fourth Hospital (Approval number: 20200721-046). This study is a single-center, randomized, 2-arm, evaluator-blinded clinical trial. In all, 90 patients with thyroid cancer undergoing thyroidectomy will be enrolled in this study. The inclusion criteria includes: patients aged between 20 and 60 years old; ASA I-II classification; normal platelet coagulation and count function. The exclusion criteria contains: people with the intellectual and cognitive impairment (behavioral-cognitive intervention); BMI above 35 kg/m 2 ; the history of renal and hepatic dysfunction; and patients refuse to participate in this study. Both the patients in psychological intervention group and control group should receive the routine care, while the psychological intervention group also needs to receive the additional proper psychological nursing interventions. The emotional disorders are detected with the Chinese version of Profile of Mood States-Brief. And the patients’ life quality is evaluated with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core Questionnaire (QLQ-C30, version 3.0). All the data are collated into Microsoft Excel 2010 and analyzed with SPSS 12.0 (IBM). Results: It is assumed that psychological nursing intervention could alleviate the psychological distress of patients with thyroid cancer and improve their quality of life. Conclusion: This study can provide the reliable evidence regarding the influence of psychological nursing intervention against the life quality and psychological distress of the patients with thyroid cancer. Trial registration: This study protocol is registered in Research Registry (researchregistry5937).

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“…Anaplastic thyroid carcinoma (ATC) is a rare but devastating type of thyroid cancer that accounts for approximately 2% of all thyroid carcinoma (TC) cases. 1 Despite its low prevalence, ATC is associated with a median overall survival (OS) of 3 to 10 months and is responsible for more than half of TC-related deaths. 2 - 4 ATC arises from the follicular cells of the thyroid gland.…”

Section: Introductionmentioning

confidence: 99%

Identification of Hub Genes in Anaplastic Thyroid Carcinoma: Evidence From Bioinformatics Analysis

Zhu

et al. 2020

Technol Cancer Res Treat

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Anaplastic thyroid carcinoma (ATC) is a rare type of thyroid cancer that results in fatal clinical outcomes; the pathogenesis of this life-threatening disease has yet to be fully elucidated. This study aims to identify the hub genes of ATC that may play key roles in ATC development and could serve as prognostic biomarkers or therapeutic targets. Two microarray datasets (GSE33630 and GSE53072) were obtained from the Gene Expression Omnibus database; these sets included 16 ATC and 49 normal thyroid samples. Differential expression analyses were performed for each dataset, and 420 genes were screened as common differentially expressed genes using the robust rank aggregation method. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to explore the potential bio-functions of these differentially expressed genes (DEGs). The terms and enriched pathways were primarily associated with cell cycle, cell adhesion, and cancer-related signaling pathways. Furthermore, a protein-protein interaction network of DEG expression products was constructed using Cytoscape. Based on the whole network, we identified 7 hub genes that included CDK1, TOP2A, CDC20, KIF11, CCNA2, NUSAP1, and KIF2C. The expression levels of these hub genes were validated using quantitative polymerase chain reaction analyses of clinical specimens. In conclusion, the present study identified several key genes that are involved in ATC development and provides novel insights into the understanding of the molecular mechanisms of ATC development.

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The role of surgery in anaplastic thyroid cancer: A systematic review

Cited by 45 publications

References 41 publications

Expressional Analysis of Vascular Endothelial Growth Factor A (VEGFA) in Patients with Thyroid Cancer

Expressional Analysis of Vascular Endothelial Growth Factor A (VEGFA) in Patients with Thyroid Cancer

Psychological nursing intervention reduces psychological distress in patients with thyroid cancer

Identification of Hub Genes in Anaplastic Thyroid Carcinoma: Evidence From Bioinformatics Analysis

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