The role of Swietenia seed extract in ameliorating blood glucose level for potential treatment of gestational diabetes mellitus: A literature review

Abstract

Gestational diabetes mellitus (GDM) can be defined as glucose intolerance identified for the first time during pregnancy. The number of diabetes occur in pregnancy about 1 of 10 cases, but the use of pharmacological drug needs to be considered. So, there is non-pharmacological treatment for alternative such as of using mahogany seeds that have potential hypoglycemia activity. The aim of this study to provide a comprehensive understanding the roles of Swietenia seeds extract in ameliorating blood glucose level for potential treatment of gestational diabetes mellitus condition. This study uses a systematic literature Review based on PRISMA-P. To identify the analyzed literature, we used five databases [including Google Scholar, PubMed, ProQuest, Science direct, and Springer] with relevant keywords using Boolean. Selected articles should discuss about mahogany seeds (Swietenia macrophylla and Swietenia mahogany) as an antidiabetic candidate. The search from 5 databases yielded 12 eligible articles to analyze. 7 articles discuss about Swietenia macrophylla King and 5 articles about Swietenia mahogani (L.) Jacq that related as an antidiabetic effect. Both of Swietenia macrophylla and Swietenia mahogani have potential role as antidiabetic agent to reduce blood glucose level and can be potential treatment option in patients with GDM.