The Role of Syndrome Differentiation in the Clinical Efficacy of Punica granatum on Patients with Ulcerative Colitis

Kamali, Mohammadali; Khodadoost, Mahmood; Heydari, Mojtaba; Tavakoli, Hamid; Hajimehdipoor, Homa; Adibi, Payman

doi:10.5812/ircmj.40810

Cited by 5 publications

(1 citation statement)

References 8 publications

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“…For example, patients treated with A. paniculata extract (HMPL-004) at a dose of 1800 mg daily were more likely to achieve a clinical response than were those receiving a placebo [191]. In the same way, another study suggested the effect of P. granatum peel extract (6 grams per day) on UC in patients [192].…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Medicinal Plants in the Treatment of Colitis: Evidence from Preclinical Studies

et al. 2017

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Ulcerative colitis is a chronic inflammatory condition whose treatment includes aminosalicylates, corticosteroids, and immunomodulators. Medicinal plants seem to be an important alternative treatment for this condition. They have been the subject of a great number of studies in recent years. This study was conducted to systematically review the medicinal plants tested in experimental models of ulcerative colitis. We conducted a systematic literature search through specialized databases (PUBMED, SCOPUS, EMBASE, MEDLINE, LILACS, SCIELO, and SCISEARCH) and selected articles published between January 2000 and June 21, 2016 by using ?medicinal plants? and ?ulcerative colitis? as key words. Sixty-eight studies were included, and the families Asteraceae and Lamiaceae presented the largest number of studies, but plants from several other families were cited; many of them have shown good results in experimental animals. However, only a few species (such as Andrographis paniculata and Punica granatum) have undergone clinical tests against ulcerative colitis, and the observation that many preclinical studies reviewed are purely descriptive has certainly contributed to this fact. Chemical constituents (mainly flavonoids and terpenes) seem to play a role in the effects of the plants. Thus, the data herein reviewed reinforce the potential of medicinal plants as a source of alternative approaches to the treatment of ulcerative colitis.

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Section: Strengths and Limitationsmentioning

confidence: 99%

Medicinal Plants in the Treatment of Colitis: Evidence from Preclinical Studies

et al. 2017

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A review of inflammatory bowel disease from the perspective of Persian medicine

Hasheminasab,

Azimi

2024

EXPLORE

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Update on the Potential of Punica granatum L. Traditional Uses and Pharmacological Uses: A Review

Dogara,

Hama,

Ozdemir

2024

Advances in Pharmacological and Pharmaceutical Sciences

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Since the dawn of civilization, humans have turned to plants as a reliable source of safe and efficient treatment for a wide variety of medical conditions. The medicinal value of Punica granatum has been recognized for some time. Inflammation, diabetes, parasitic infections, cancer, and many other diseases have all been treated with its components. This review provides a comprehensive overview of the current biological data (those from 2018 to 2023 are included in the preclinical studies while articles of clinical studies have no limit due to their scarcity) and explores the potential applications of P. granatum as a novel platform for treating various disease conditions. Electronic searches for scholarly articles were performed using Elsevier, Springer, Google Scholar, Taylor & Francis, PubMed, and Scopus. Research the following terms: “Punica granatum,” “chemical composition,” “antioxidant,” “antibacterial,” “anti‐diabetic,” “anticancer,” and other relevant terms. It has been scientifically proven that the fruit peel exhibits antioxidant, anti‐inflammatory, antimicrobial, antiparasitic, antidiabetic, hepatoprotective, nerve‐recovery, antihypertensive, anti‐asthma, wound healing, and anticancer activities. Based on both preclinical and clinical experimentation on P. granatum, there is considerable evidence that supports the use of P. granatum extract as therapeutic agent for different ailments. The review paved the ground to precursor evidence of P. granatum extract benefits with its antioxidant, anti‐inflammatory, antimicrobial, and antidiabetic properties. Furthermore, clinical trials stand out as a substrate supporting these effects with the enhancements of ailments including post menstrual, menstrual pain, semen quality, knee joint arthritis, and cardiovascular‐related diseases. Nonetheless, more controlled large‐scale clinical trials are needed for all the conditions to determine the effectiveness and risk benefit profile of P. granatum extract for these diseases.

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The Role of Syndrome Differentiation in the Clinical Efficacy of Punica granatum on Patients with Ulcerative Colitis

Cited by 5 publications

References 8 publications

Medicinal Plants in the Treatment of Colitis: Evidence from Preclinical Studies

Medicinal Plants in the Treatment of Colitis: Evidence from Preclinical Studies

A review of inflammatory bowel disease from the perspective of Persian medicine

Update on the Potential of Punica granatum L. Traditional Uses and Pharmacological Uses: A Review

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