The role of take-home naloxone in the epidemic of opioid overdose involving illicitly manufactured fentanyl and its analogs

Kim, Hong; Connors, Nicholas J.; Mazer‐Amirshahi, Maryann

doi:10.1080/14740338.2019.1613372

Cited by 30 publications

(39 citation statements)

References 110 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The early adoption and distribution of take-home naloxone have been reported to effectively prevent opioid overdose deaths 128–130 . Therefore, harm reduction strategies, such as safe injection sites, the expansion of available opioid agonist treatment, and overdose prevention training (e.g., carrying naloxone and not use drugs alone, higher dose or multiple administrations of naloxone), are needed to control the adverse effects of fentanyl and reduce overdoses 131 .…”

Section: Interventions For the Management And Prevention Of Fentanyl mentioning

confidence: 99%

The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies

et al. 2019

View full text Add to dashboard Cite

Fentanyl is a powerful opioid anesthetic and analgesic, the use of which has caused an increasing public health threat in the United States and elsewhere. Fentanyl was initially approved and used for the treatment of moderate to severe pain, especially cancer pain. However, recent years have seen a growing concern that fentanyl and its analogs are widely synthesized in laboratories and adulterated with illicit supplies of heroin, cocaine, methamphetamine, and counterfeit pills, contributing to the exponential growth in the number of drug-related overdose deaths. This review summarizes the recent epidemic and evolution of illicit fentanyl use, its pharmacological mechanisms and side effects, and the potential clinical management and prevention of fentanyl-related overdoses. Because social, economic, and health problems that are related to the use of fentanyl and its analogs are growing, there is an urgent need to implement large-scale safe and effective harm reduction strategies to prevent fentanyl-related overdoses.

show abstract

Section: Interventions For the Management And Prevention Of Fentanyl mentioning

confidence: 99%

The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies

et al. 2019

View full text Add to dashboard Cite

show abstract

“…33 While naloxone kits have been an effective harm reduction measure, it is increasingly recognized that the doses they offer may be inadequate to reverse an overdose involving F/FAs. 31…”

Section: Negative Results Of Naloxone Administrationmentioning

confidence: 99%

“…30 When naloxone is used, larger amounts and multiple doses are often required. 30,31 In 2012, 14.5% of overdose patients required multiple naloxone doses, but by 2015, with the greater penetration of F/FAs, the number rose to 18.2%. As F/FA use increased during COVID-19, this number is likely to increase even further.…”

Section: Anatomy Of An Opioid Overdose Rescuementioning

confidence: 99%

Overdoses due to fentanyl and its analogues (F/FAs) push naloxone to the limit

et al. 2021

View full text Add to dashboard Cite

What is known and Objective: Food and Drug Administration (FDA) risk evaluation and mitigation strategies (REMs) encourage emergency responders, paramedics, law enforcement agents, and even laypeople to be trained in the administration of naloxone with the intent of rescuing individuals from a known or suspected opioid overdose.Comment: Although naloxone is generally safe and effective at reversing respiratory depression caused by a conventional opioid such as morphine or heroin by competing with the opioid and displacing it from the μ-opioid receptor, questions increasingly are arising as to whether naloxone can adequately reverse opioid overdoses that may involve the potent opioids fentanyl and its analogues (F/FAs). In other words, as more and more opioid overdoses involve F/FAs, can naloxone keep up? What is new and Conclusion:As a competitive antagonist at μ-opioid receptors, naloxone is often a life-saving agent in cases of overdose caused by conventional opioids, but it may not be versatile or powerful enough to combat the rising tide of overdoses due to fentanyl and its illicit analogues, or in cases of overdose involving combinations of opioids and non-opioids.

show abstract

“…Fentanyl and its analogues cause more rapid onset of severe life-threatening respiratory depression than other opioids. The onset of respiratory arrest caused by fentanyl/fentanyl analogues was estimated at two minutes, whereas in the case of heroin it is up to 10 minutes [31].…”

Section: ■ Treatment Of New Fentanyl Analogue Dependence and Procedur...mentioning

confidence: 99%

Prevalence, detection, symptoms of intoxication and treatment of new fentanyl analogue overdose with cyklopropylfentanyl (MAF) as an example

Fudalej¹

2021

ain

View full text Add to dashboard Cite

show abstract

The role of take-home naloxone in the epidemic of opioid overdose involving illicitly manufactured fentanyl and its analogs

Cited by 30 publications

References 110 publications

The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies

The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies

Overdoses due to fentanyl and its analogues (F/FAs) push naloxone to the limit

Prevalence, detection, symptoms of intoxication and treatment of new fentanyl analogue overdose with cyklopropylfentanyl (MAF) as an example

Contact Info

Product

Resources

About