2008
DOI: 10.1210/en.2008-0322
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The Role of Tanshinone IIA in the Treatment of Obesity through Peroxisome Proliferator-Activated Receptor γ Antagonism

Abstract: Peroxisome proliferator-activated receptor (PPAR) gamma is a nuclear receptor that coordinates carbohydrate and lipid metabolism, and is a therapeutic target for type 2 diabetes. Tanshinone IIA (Tan) is a lipophilic diterpene that is widely used to treat cardiovascular diseases in traditional Chinese medicine, and has recently been found to reduce body weight and lower blood lipids. However, its underlying mechanism of antiadipogenic effects remains unknown. Here, we report that Tan inhibits 3T3-L1 preadipocyt… Show more

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Cited by 101 publications
(86 citation statements)
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“…Citrus flavonoids have been shown to inhibit adipogenesis and to decrease adiposity which can be explained in part by regulating the PPAR expression levels both in vivo and in vitro [38,39]. The result in the present study showed that the expression amount of PPARγ in white adipose tissue in the high doses of aloe flavonoids treated group(HDG) significantly increased as compared with what in the positive group, indicating that normal expression of PPARγ in adipose tissue was critical for prevention of blood lipid levels in hyperlipidemia, this result consistent with previous findings that suppressing PPARγ-activity can inhibit adipocyte differentiation in vitro [40], and other result showed that citrus polymethoxylated flavonoids improve lipid and glucose homeostasis through regulating the expression of PPARα and PPARγ [41]. Although compared with the model group, the PPARγ mRNA expression in the Aloe flavonoids treatment groups were not significantly increased, it still showed an increase tendency in our study, and the high dose Aloe flavonoids have the better effect on the gene of PPARγ.…”
Section: Discussionsupporting
confidence: 91%
“…Citrus flavonoids have been shown to inhibit adipogenesis and to decrease adiposity which can be explained in part by regulating the PPAR expression levels both in vivo and in vitro [38,39]. The result in the present study showed that the expression amount of PPARγ in white adipose tissue in the high doses of aloe flavonoids treated group(HDG) significantly increased as compared with what in the positive group, indicating that normal expression of PPARγ in adipose tissue was critical for prevention of blood lipid levels in hyperlipidemia, this result consistent with previous findings that suppressing PPARγ-activity can inhibit adipocyte differentiation in vitro [40], and other result showed that citrus polymethoxylated flavonoids improve lipid and glucose homeostasis through regulating the expression of PPARα and PPARγ [41]. Although compared with the model group, the PPARγ mRNA expression in the Aloe flavonoids treatment groups were not significantly increased, it still showed an increase tendency in our study, and the high dose Aloe flavonoids have the better effect on the gene of PPARγ.…”
Section: Discussionsupporting
confidence: 91%
“…The aortic sinus cryosections were analyzed for atherosclerotic lesion size with Oil Red O staining and immunohistochemistry staining as previously described ( 13 ). The dosage of the drug used in the current study was evaluated according to a small pilot study by us ( 13 ) and reports by others ( 20 ). All animal experimental procedures were performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals and were approved by the Institutional Ethical Committee for Animal Research at Sun Yat-sen University.…”
Section: Apoementioning
confidence: 99%
“…[6][7][8] Previous studies using a reporter gene assay for PPARα/γ successfully demonstrated their various agonists and antagonists from natural resources. [9][10][11][12][13] In the course of our studies on searching for anti-diabetic compounds, we examined the effects of various extracts of medicinal plants and isolated compounds on enhancement of triglyceride (TG) accumulation, as a marker of adipogenesis, in 3T3-L1 cells. Among the compounds tested, several constituents exhibited adipogenic effects similar to PPARγ agonists in 3T3-L1 cells, although they did not act as the agonist for the receptor levels using a nuclear cofactor assay system.…”
Section: Introductionmentioning
confidence: 99%