The role of taurine on anxiety-like behaviors in zebrafish: A comparative study using the novel tank and the light–dark tasks

Mezzomo, Nathana J.; Silveira, Ariane; Giuliani, Giulie S.; Quadros, Vanessa A.; Rosemberg, Denis B.

doi:10.1016/j.neulet.2015.12.037

Cited by 84 publications

(56 citation statements)

References 35 publications

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“…Our finding linking NAc taurine concentrations with natural variations in trait anxiety in healthy humans seems remarkable, given the existence of studies in rodents (Chen et al, 2004;El Idrissi et al, 2009;Kong et al, 2006;Zhang and Kim, 2007) and zebrafish (Mezzomo et al, 2017(Mezzomo et al, , 2016 have reported reductions in anxiety-like behaviors following treatment with taurine. Information about taurine in the human brain in the context of anxiety had previously been lacking.…”

Section: Discussionmentioning

confidence: 71%

“…Previous work has highlighted imbalances in neural excitation and inhibition (E/I) in several brain areas in anxiety and mood disorders) and following stress exposure (Cordero et al, 2016;Hasler et al, 2010;Houtepen et al, 2017;Moghaddam, 2002;Popoli et al, 2012;Sandi, 2011 (Davison and Kaczmarek, 1971;El Idrissi and Trenkner, 2004;Jia et al, 2008). (Mezzomo et al, 2016;Zhang and Kim, 2007). Recently, a role for the nucleus accumbens (NAc), the main anatomical constituent of the ventral striatum (VS), is emerging in the context of anxiety (Gunaydin and Kreitzer, 2016;Levita et al, 2012) interconnected with the NAc function in behavioral adaptation (Haber and Behrens, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Nucleus accumbens neurochemistry in human anxiety: A 7 T¹H-MRS study

Strasser

Xin

Gruetter

et al. 2018

Preprint

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Individual differences in anxiety provide a differential predisposition to develop neuropsychiatric disorders. The neurochemical underpinnings of anxiety remain elusive, particularly in deep structures, such as the nucleus accumbens (NAc) whose involvement in anxiety is being increasingly recognized.We examined the associations between the neurochemical profile of human NAc metabolites involved in neural excitation and inhibition and inter-individual variation in temperamental and situational anxiety. Twenty-seven healthy 20-30 years-old human males were phenotyped with questionnaires for state and trait anxiety (State-Trait Anxiety Inventory, STAI), social anxiety (Liebowitz Social Anxiety Scale), depression (Beck Depression Inventory, BDI) and fatigue (Mental and Physical State Energy and Fatigue Scales, SEF). Using proton magnetic resonance spectroscopy ( 1 H-MRS) at 7 Tesla (7T), we measured metabolite levels for glutamate, glutamine, GABA and taurine in the NAc with. Salivary cortisol was also measured. Strikingly, trait anxiety was negatively associated with NAc taurine content. Perceived situational stress was negatively associated with NAc GABA, while positively with the Glu/GABA ratio. These findings were specific, as no correlation was observed between NAc taurine or GABA and other phenotypic variables examined (i.e., state anxiety, social anxiety, depression, or cortisol), except for a negative correlation between taurine and state physical fatigue. This first 7T study of NAc neurochemistry shows relevant metabolite associations with individual variation in anxiety traits and situational stress and state anxiety measurements. The novel identified association between NAc taurine levels and trait anxiety may pave the way for clinical studies aimed at identifying new treatments for anxiety and related disorders.

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Section: Discussionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Nucleus accumbens neurochemistry in human anxiety: A 7 T¹H-MRS study

Strasser

Xin

Gruetter

et al. 2018

Preprint

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“…The novel tank diving test is commonly used for analyzing exploratory and locomotor profiles. Moreover this task is often used to analyze anxiety-like behavior being sensitive to a range of anxiogenic and anxiolytic drugs in absence or presence of different aversive stimulus (Egan et al, 2009; Maximino et al, 2018; Mezzomo, Silveira, Giuliani, Quadros, & Rosemberg, 2016; Wong et al, 2010). Zebrafish ( n= 23 ) were placed individually in a novel tank (22 - 26 cm length x 15 cm height x 9 cm width) ( Fig.…”

Section: Methodsmentioning

confidence: 99%

Moderate early-life stress improves adult zebrafish (Danio rerio) spatial short-term memory but does not affect social and anxiety-like responses

Fontana

Gibbon

Sudwarts

et al. 2020

Preprint

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5Early-life stress (ELS) is defined as a short or chronic period of trauma, environmental or 3 6 social deprivation, which can affect different neurochemical and behavioral patterns during 3 7 adulthood. Zebrafish (Danio rerio) have been widely used as a model system to understand human 3 8 neurodevelopmental disorders and display translationally relevant behavioral and stress-regulating 3 9systems. In this study, we aimed to investigate the effects of moderate ELS by exposing young 4 0 animals (six weeks post-fertilization), for three consecutive days, to three stressors, and analyzing 4 1 the impact of this on adult zebrafish behavior (sixteen weeks post-fertilization). The ELS impact in 4 2 adults was assessed though analysis of performance on tests of unconditioned memory (free 4 3 movement pattern Y-maze test), exploratory and anxiety-related task (novel tank diving test) and 4 4 social cohesion (shoaling test). Here, we show for the first time that moderate ELS increases the 4 5 number of pure alternations compared to pure repetitions in the unconditioned Y-maze task, 4 6suggesting increased spatial short-term memory, but has no effect on shoal cohesion, locomotor 4 7 profile or anxiety-like behavior. Overall, our data suggest that moderate ELS may be linked to 4 8 adaptive flexibility which contributes to build 'resilience' in adult zebrafish by improving short-4 9 term spatial memory performance. 5 0 5 1

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“…The novel tank diving test is commonly used for analyzing locomotor and anxiety-like phenotypes in zebrafish presenting a high sensitivity to anxiolytic and anxiogenic drugs (Egan et al 2009; Kalueff et al 2013; Levin et al 2007; Maximino et al 2010; Mezzomo et al 2016; Wong et al 2010). 24 hours after the Y-maze test, animals (n = 46 ) were placed individually in a novel tank (30 cm length x 15 cm height x 12 cm width) containing 4 L of aquarium water.…”

Section: Methodsmentioning

confidence: 99%

Zebrafish (Danio rerio) behavioral laterality predicts increased short-term avoidance memory but not stress-reactivity responses

Fontana

Clay

Parker

2019

Preprint

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6Once considered a uniquely human attribute, behavioral laterality has proven to be 3 7 ubiquitous among non human animals, being frequently associated with different 3 8 neurophenotypes in rodents and fish species. Zebrafish (Danio rerio) are a versatile vertebrate 3 9 model system that has been widely used in translational neuropsychiatric research due their 4 0 highly conserved genetic homology, well characterized physiological and extensive behavioral 4 1 repertoire. Although the spontaneous left-and right-bias responses and associated behavioral 4 2 domains (e.g. stress reactivity, aggression and learning) have previously been observed in other 4 3 teleost species, no information regarding how spontaneous motor left-right bias responses of 4 4 zebrafish predicts other behavioral domains has been described. Thus, we aimed to investigate 4 5 the existence and incidence of natural left-right bias of adult zebrafish in the Y-maze test and 4 6 explore any relationship of biasedness on the performance of different behavioral domains. This 4 7 included learning about threat-cues in the fear conditioning test and locomotion and anxiety-4 8related behavior in the novel tank diving test. In conclusion, we showed for the first time that 4 9 handling in a single day (see Fig. 1). During the pair-housing period, animals had shared

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The role of taurine on anxiety-like behaviors in zebrafish: A comparative study using the novel tank and the light–dark tasks

Cited by 84 publications

References 35 publications

Nucleus accumbens neurochemistry in human anxiety: A 7 T¹H-MRS study

Nucleus accumbens neurochemistry in human anxiety: A 7 T¹H-MRS study

Moderate early-life stress improves adult zebrafish (Danio rerio) spatial short-term memory but does not affect social and anxiety-like responses

Zebrafish (Danio rerio) behavioral laterality predicts increased short-term avoidance memory but not stress-reactivity responses

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The role of taurine on anxiety-like behaviors in zebrafish: A comparative study using the novel tank and the light–dark tasks

Cited by 84 publications

References 35 publications

Nucleus accumbens neurochemistry in human anxiety: A 7 T1H-MRS study

Nucleus accumbens neurochemistry in human anxiety: A 7 T1H-MRS study

Moderate early-life stress improves adult zebrafish (Danio rerio) spatial short-term memory but does not affect social and anxiety-like responses

Zebrafish (Danio rerio) behavioral laterality predicts increased short-term avoidance memory but not stress-reactivity responses

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Nucleus accumbens neurochemistry in human anxiety: A 7 T¹H-MRS study

Nucleus accumbens neurochemistry in human anxiety: A 7 T¹H-MRS study