2020
DOI: 10.1002/jctb.6301
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The role of temperature, pH and nutrition in process development of the unique oleaginous yeast Metschnikowia pulcherrima

Abstract: BACKGROUND Lipids produced from oleaginous yeasts are a promising alternative to terrestrial oils. Despite promising cellular yields of lipid however, an industrial process remains elusive. One key processing bottleneck is the need to provide nutrient‐rich conditions for cellular growth and then extended nutrient‐depleted conditions for lipid accumulation. Surprisingly, investigations detailing process development, particularly with a focus on kinetics, are rare in this field. RESULTS In this investigation we … Show more

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Cited by 15 publications
(31 citation statements)
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“…Consequently, the yeast achieved maximum biomass and lipid production rates of 0.98 and 0.31 g L −1 h −1 (average over 6.8 h), respectively, during the growth on glucose. These reaction rates are higher than those reported during batch growth on glucose in nitrogen-limited broth (0.72 and 0.25 g L −1 h −1 , respectively [3]), but this was impacted by the higher frequency of sampling and process parameters influencing fermentation kinetics such as the higher amount of yeast extract supplied initially [25] and the use of phosphoric acid for pH control (Fig. 1).…”
Section: Maltooligosaccharide Uptake By M Pulcherrimamentioning
confidence: 72%
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“…Consequently, the yeast achieved maximum biomass and lipid production rates of 0.98 and 0.31 g L −1 h −1 (average over 6.8 h), respectively, during the growth on glucose. These reaction rates are higher than those reported during batch growth on glucose in nitrogen-limited broth (0.72 and 0.25 g L −1 h −1 , respectively [3]), but this was impacted by the higher frequency of sampling and process parameters influencing fermentation kinetics such as the higher amount of yeast extract supplied initially [25] and the use of phosphoric acid for pH control (Fig. 1).…”
Section: Maltooligosaccharide Uptake By M Pulcherrimamentioning
confidence: 72%
“…To assess the growth of M. pulcherrima on the maltooligosaccharides composing GS, batch fermentations were conducted on the 2- and 50-L scale, providing an insight into the scalability of M. pulcherrima . As nitric acid has been routinely used in previous stirred tank reactor fermentations with M. pulcherrima [ 3 , 16 , 25 ], but phosphoric acid being safer to handle at scale, the impact of both pH control agents on the fermentation parameters was additionally investigated.…”
Section: Resultsmentioning
confidence: 99%
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