The role of tensor veli platini muscle (TVP) and levetor veli platini muscle (LVP) in the opening and closing of pharyngeal orifice of Eustachian tube

Gyanwali, Bibek; Li, Heng; Xie, Lihong; Zhu, Meichan; Wu, Zhenggui; He, Guobin; Tang, Anzhou

doi:10.3109/00016489.2015.1107192

Cited by 9 publications

(4 citation statements)

References 14 publications

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“…The Eustachian tube (ET) has 3 primary functions pertaining to the middle ear, including ventilation, middle ear clearance, and protection of the middle ear against nasopharyngeal pathogens (Gyanwali et al, 2016). Otitis media with effusion (OME), acute otitis media, cholesteatoma, and atelectasis are some of the pathologic manifestations of deficiency in ET function (Bluestone and Bluestone, 2005).…”

Section: Introductionmentioning

confidence: 99%

Differences in the Tensor Veli Palatini Between Adults With and Without Cleft Palate Using High-Resolution 3-Dimensional Magnetic Resonance Imaging

George

Kotlarek

Kuehn

et al. 2018

The Cleft Palate Craniofacial Journal

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Section: Introductionmentioning

confidence: 99%

Differences in the Tensor Veli Palatini Between Adults With and Without Cleft Palate Using High-Resolution 3-Dimensional Magnetic Resonance Imaging

George

Kotlarek

Kuehn

et al. 2018

The Cleft Palate Craniofacial Journal

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“…Furthermore, we found that secretory otitis media was caused by Eustachian tube dysfunction, with the histopathological changes occurring in the tree shrew like those in humans. 21 In the present study, we irradiated the TVP muscle of tree shrews to develop an animal model to investigate the pathogenesis of radiation-induced muscle injury. The results of this study may serve as a scientific basis for future research and treatment of complications caused by radiation-induced muscle injury.…”

Section: Introductionmentioning

confidence: 99%

An Investigation of the Mechanisms of Radiation-Induced Muscle Injury in a Tree Shrew (Tupaia belangeri) Model

et al. 2022

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Background Animal models suitable for investigating mechanisms behind radiation-induced muscle injury are lacking. We developed a tree shrew model of such injury and investigated pathological changes and mechanisms. Methods Animals were divided into control (n = 5), radiation-induced acute injury (n = 5), and radiation-induced chronic injury (n = 5) groups. Tensor veli palatini (TVP) muscles of acute injury and chronic injury groups were dissected under a microscope at 1 and 24 weeks after radiation therapy, respectively. TVP muscles were stained with HE and Masson to visualize pathological changes. ELISA was performed to measure oxidative injury. RT-qPCR and immunohistochemical staining was performed to measure expression levels of miR-206 and histone deacetylase 4 (HDAC4). Results Compared to the control group, acute injury group showed a significant decrease in miR-206 expression (.061 ± .38, P < .05) and a significant increase in HDAC4 expression (37.05 ± 20.68, P < .05). Chronic injury group showed a significant decrease in miR-206 expression (.23 ± .19, P < .05) and a significant increase in HDAC4 expression (9.66 ± 6.12, P < .05). Discussion A tree shrew model of radiation-induced muscle injury was established by exposing TVP muscle region to radiation of 20-Gy. Experimental results indicated that injury caused by radiation persisted despite gradual healing of the TVP muscle and miR-206 regulatory pathway plays a key role in regulating radiation-induced muscle injury.

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“…Estes músculos são os responsáveis por aumentar a luz da tuba auditiva. Diante do comprometimento destes, a tuba auditiva não abre corretamente o que pode favorecer ao acúmulo de fluidos serosos na orelha média (13).…”

Section: Anatomia E Fisiologiaunclassified

“…Dentre os músculos palatinos implicados na MP essencial destacam-se o tensor do véu palatino (TVP) e o levantador do véu palatino (LVP) que possuem inserção na tuba auditiva e desempenham papel importante na mecânica de abertura da mesma (11)(12)(13).…”

Section: Introductionunclassified

Zumbido objetivo causado por mioclonia palatina

Stefanelli¹

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Ao Grande Arquiteto, por me guiar e me iluminar em meus caminhos nesta vida.A minha esposa e grande companheira, Laura, por todo apoio, incentivo e tolerância nas longas noites de estudos. E à nossa pequena Alice, que veio para trazer luz e consciência em nossas vidas.Aos meus primeiros professores, meus pais, Osvaldo e Celina, por todos ensinamentos e tudo que me proporcionaram para que eu chegasse até aqui.Ao meu Irmão Fred por todo suporte dado para a realização desta tese. A minha irmã Lívia, pelo carinho.A todos da família Borella: Claudia, Marina, Otávio, Beatriz, Claudio, Vená e Giovana, pela compreensão nos momentos de ausência e pela torcida. Ao meu orientador Prof. Fausto Bérzin, pelo exemplo de humildade, dedicação e superação. Por nos ensinar, além de todo conhecimento técnico, o lado artístico de se fazer ciência e o quão bom é conviver unidos e em harmonia em um ambiente acadêmico. À Prof a Dr a Jeanne Oiticica, por me receber tão prontamente e abrir as portas do Departamento de Zumbido do Hospital das Clínicas da Faculdade de Medicina (USP), para os estudos com Osteopatia. Obrigado pela confiança e pela indispensável contribuição neste trabalho. À Ana Adelina Della Torre, esposa de meu amigo Gabriel Boal, pela amizade e confiança em me apresentar a Dra. Jeanne. Ao Prof. Dr. Gilberto Formigoni, por compartilhar seu conhecimento e experiência, assim como pelos contatos realizados no Hospital das Clínicas da Faculdade de Medicina (USP).

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The role of tensor veli platini muscle (TVP) and levetor veli platini muscle (LVP) in the opening and closing of pharyngeal orifice of Eustachian tube

Abstract: Otomiscroscopic, tympanograph, and pathological examination showed the presence of middle ear disease in those animals whose TVP was excised and paralyzed, but on those groups of animals whose LVP was excised and paralyzed, abnormalities were seen.

Cited by 9 publications

References 14 publications

Differences in the Tensor Veli Palatini Between Adults With and Without Cleft Palate Using High-Resolution 3-Dimensional Magnetic Resonance Imaging

Differences in the Tensor Veli Palatini Between Adults With and Without Cleft Palate Using High-Resolution 3-Dimensional Magnetic Resonance Imaging

An Investigation of the Mechanisms of Radiation-Induced Muscle Injury in a Tree Shrew (Tupaia belangeri) Model

Zumbido objetivo causado por mioclonia palatina

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