The role of tetrahydrocurcumin in disease prevention and treatment

Zhou, Mengting; Li, Rui; Hua, Hua; Dai, Ying; Yin, Zhujun; Li, Li; Zeng, Jin; Yang, Mengni; Zhao, Junning; Tan, Ruirong

doi:10.1039/d3fo05739a

Food Funct.

2024

DOI: 10.1039/d3fo05739a

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The role of tetrahydrocurcumin in disease prevention and treatment

Mengting Zhou,

Rui Li,

Hua Hua

et al.

Abstract: Tetrahydrocurcumin showed potential biological activities in neurologic, cardiovascular, respiratory, liver, metabolic, renal, skin and inflammatory diseases as well as cancer.

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Cited by 3 publications

References 200 publications

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A Multifunctional Nanocomposite Hydrogel Delivery System Based on Dual‐Loaded Liposomes for Scarless Wound Healing

Xing,

Xia,

Tang

et al. 2024

Adv Healthcare Materials

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Increased inflammatory responses and oxidative stress at the wound site following skin trauma impair healing. Furthermore, skin scarring places fibroblasts under severe mechanical stress and aggravates pathological fibrosis. A novel liposomal composite hydrogel is engineered for wound microenvironment remodeling, incorporating dual‐loaded liposomes into gelatin methacrylate to create a nanocomposite hydrogel. Notably, tetrahydrocurcumin (THC) and hepatocyte growth factor (HGF) are encapsulated in the hydrophobic and hydrophilic layers of liposomes, respectively. The composite hydrogel maintains porous nanoarchitecture, demonstrating sustainable THC and HGF release and enhanced mechanical properties and biocompatibility. This system effectively promotes cell proliferation and angiogenesis and attenuates apoptosis. It decreases the expression of the inflammatory factors by inhibiting the high‐mobility group box /receptor for advanced glycation end product/NF‐κB (HMGB1/RAGE/NF‐κB)pathway and increases macrophage polarization from M1 to M2 in vitro, effectively controlling inflammatory responses. It exhibits remarkable antioxidant properties by scavenging excess reactive oxygen species and free radicals. Most importantly, it effectively prevents scar formation by restraining the transforming growth factor beta (TGF‐β)/Smads pathway that downregulates associated fibrotic factors. It demonstrates strong therapeutic effects against inflammation and fibrosis in a rat skin wound model with biosafety, advancing the development of innovative hydrogel‐based therapeutic delivery strategies for clinical scarless wound therapy.

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A Multifunctional Nanocomposite Hydrogel Delivery System Based on Dual‐Loaded Liposomes for Scarless Wound Healing

Xing,

Xia,

Tang

et al. 2024

Adv Healthcare Materials

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Tetrahydrocurcumin targets TRIP13 inhibiting the interaction of TRIP13/USP7/c-FLIP to mediate c-FLIP ubiquitination in triple-negative breast cancer

Sun,

Zhang,

Cao

et al. 2024

Journal of Advanced Research

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Tetrahydrocurcumin alleviates di-(2-ethylhexyl) phthalate-induced adipose tissue dysfunction and testicular toxicity in adult mice: possible involvement of adiponectin-adipoR signaling in the testis

Anwar,

Chu,

Tsai

et al. 2025

Food Funct.

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The role of tetrahydrocurcumin in disease prevention and treatment

Abstract: Tetrahydrocurcumin showed potential biological activities in neurologic, cardiovascular, respiratory, liver, metabolic, renal, skin and inflammatory diseases as well as cancer.

Cited by 3 publications

References 200 publications

A Multifunctional Nanocomposite Hydrogel Delivery System Based on Dual‐Loaded Liposomes for Scarless Wound Healing

A Multifunctional Nanocomposite Hydrogel Delivery System Based on Dual‐Loaded Liposomes for Scarless Wound Healing

Tetrahydrocurcumin targets TRIP13 inhibiting the interaction of TRIP13/USP7/c-FLIP to mediate c-FLIP ubiquitination in triple-negative breast cancer

Tetrahydrocurcumin alleviates di-(2-ethylhexyl) phthalate-induced adipose tissue dysfunction and testicular toxicity in adult mice: possible involvement of adiponectin-adipoR signaling in the testis

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