The role of Th-17 cells and IL-17 in the metastatic spread of breast cancer: As a means of prognosis and therapeutic target

Shibabaw, Tewodros; Teferi, Banchamlak; Ayelign, Birhanu

doi:10.3389/fimmu.2023.1094823

Cited by 17 publications

(4 citation statements)

References 156 publications

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“…Moreover, it has been reported that the tumor-infiltrating γδT17 subset mediating pro-angiogenic IL-17 thereby inducing the expression of VEGF-A, CXCL8, GM-CSF, and TNFα release, can actively participate in the angiogenic process and the recruitment of MDSCs ( Wu et al, 2014 ). IL-17 also indirectly promotes angiogenesis by activating the expression of CCL17 and CCL22 and facilitates Treg cell migration to tumor ( Shibabaw et al, 2023 ).…”

Section: Signaling From Immune Cells To Tecsmentioning

confidence: 99%

Signaling crosstalk between tumor endothelial cells and immune cells in the microenvironment of solid tumors

Xu,

Miller,

Tykodi

et al. 2024

Front. Cell Dev. Biol.

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Tumor-associated endothelial cells (TECs) are crucial mediators of immune surveillance and immune escape in the tumor microenvironment (TME). TECs driven by angiogenic growth factors form an abnormal vasculature which deploys molecular machinery to selectively promote the function and recruitment of immunosuppressive cells while simultaneously blocking the entry and function of anti-tumor immune cells. TECs also utilize a similar set of signaling regulators to promote the metastasis of tumor cells. Meanwhile, the tumor-infiltrating immune cells further induce the TEC anergy by secreting pro-angiogenic factors and prevents further immune cell penetration into the TME. Understanding the complex interactions between TECs and immune cells will be needed to successfully treat cancer patients with combined therapy to achieve vasculature normalization while augmenting antitumor immunity. In this review, we will discuss what is known about the signaling crosstalk between TECs and tumor-infiltrating immune cells to reveal insights and strategies for therapeutic targeting.

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Section: Signaling From Immune Cells To Tecsmentioning

confidence: 99%

Signaling crosstalk between tumor endothelial cells and immune cells in the microenvironment of solid tumors

Xu,

Miller,

Tykodi

et al. 2024

Front. Cell Dev. Biol.

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“…In most of these studies, IL17-producing T-cells have been associated with disease progression, worse prognosis, triple-negative molecular subtypes, shorter disease-free survival (DFS), and genes related to the tumors' proliferation and survival [54][55][56]. The pro-tumor properties of Th17 cells in BC (Figure 2) are attributed to multiple mechanisms, including the regulation of angiogenesis, induction of pro-invasive factors (i.e., IL-17, IL-22, and IL-23), metalloproteinases (MMPs) that promote proliferation, survival, and the invasion of malignant cells, interfering with CD8 + T-cell migration through the activation of STAT3 signaling and subsequent reduction of CXCR3 expression [57][58][59][60]. The role of IL-17 in angiogenesis is enhanced through the induction of angiogenic factors such as MMP-2, MMP-9, vascular endothelial growth factor (VEGF), and CXCL8 [61].…”

Section: Th17 In Breast Carcinomamentioning

confidence: 99%

Dual Functions of T Lymphocytes in Breast Carcinoma: From Immune Protection to Orchestrating Tumor Progression and Metastasis

Zareinejad,

Mehdipour,

Roshan-Zamir

et al. 2023

Cancers

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Breast cancer (BC) is the most common cancer type in women and the second leading cause of death. Despite recent advances, the mortality rate of BC is still high, highlighting a need to develop new treatment strategies including the modulation of the immune system and immunotherapies. In this regard, understanding the complex function of the involved immune cells and their crosstalk with tumor cells is of great importance. T-cells are recognized as the most important cells in the tumor microenvironment and are divided into several subtypes including helper, cytotoxic, and regulatory T-cells according to their transcription factors, markers, and functions. This article attempts to provide a comprehensive review of the role of T-cell subsets in the prognosis and treatment of patients with BC, and crosstalk between tumor cells and T-cells. The literature overwhelmingly contains controversial findings mainly due to the plasticity of T-cell subsets within the inflammatory conditions and the use of different panels for their phenotyping. However, investigating the role of T-cells in BC immunity depends on a variety of factors including tumor types or subtypes, the stage of the disease, the localization of the cells in the tumor tissue and the presence of different cells or cytokines.

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“…Additionally, in metastatic breast cancer, up-regulation of IL-17 expression promotes MAPK activation, which leads to NF-kB pathway-mediated overexpression of MMP signaling. This, in turn, promotes tumour cell proliferation and metastasis [ 33 ].…”

Section: The Roles Of Tumour-promoting Role Of the Inflammatory Micro...mentioning

confidence: 99%

Exploring the potential use of Chinese herbs in regulating the inflammatory microenvironment of tumours based on the concept of ‘state-target identification and treatment’: a scooping review

Lian,

Lin,

Huang

et al. 2023

Chin Med

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Tumours do not exist in isolation from the organism; their growth, proliferation, motility, and immunosuppressive response are intricately connected to the tumour’s microenvironment. As tumour cells and the microenvironment coevolve, an inflammatory microenvironment ensues, propelling the phenomenon of inflammation-cancer transformation—an idea proposed by modern medicine. This review aims to encapsulate the array of representative factors within the tumour’s inflammatory microenvironment, such as interleukins (IL-6, IL-10, IL-17, IL-1β), transforming growth factor-beta (TGF-β), interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF), and matrix metalloproteinases (MMPs). Moreover, drawing upon research in traditional Chinese medicine (TCM) and pharmacology, we explore the delicate interplay between these factors and tumour-associated inflammatory cells: tumour-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), tumour-associated neutrophils (TANs) and dendritic cells (DCs). By analyzing the tumour-promoting effects of these entities, we delve into the connotations of Academician Tong Xiao-lin’s novel model of “state-target differentiation” and its application in the diagnosis and treatment of tumours. Our aim is to enhance the precision and targeting of tumour treatment in clinical practice. Delving deeper into our understanding of tumour pathogenesis through the lens of modern medicine, we discern the key etiology and pathogenesis throughout the entire developmental stage of tumours, unveiling the evolutionary patterns of Chinese Medicine (CM) states: heat state → phlegm state → stagnation state → deficiency state. Building upon this foundation, we devised a state-regulating formula. Simultaneously, drawing on pharmacological research in traditional Chinese medicine (TCM), we meticulously identified a range of targeted drugs that effectively modulate the aforementioned tumour-related mediators. This comprehensive strategy—a harmonious integration of state identification, target recognition, and simultaneous regulation—aims to elevate clinical efficacy. The fusion of TCM with Western medicine in tumour treatment introduces novel dimensions to the precise and refined application of TCM in clinical practice.

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The role of Th-17 cells and IL-17 in the metastatic spread of breast cancer: As a means of prognosis and therapeutic target

Cited by 17 publications

References 156 publications

Signaling crosstalk between tumor endothelial cells and immune cells in the microenvironment of solid tumors

Signaling crosstalk between tumor endothelial cells and immune cells in the microenvironment of solid tumors

Dual Functions of T Lymphocytes in Breast Carcinoma: From Immune Protection to Orchestrating Tumor Progression and Metastasis

Exploring the potential use of Chinese herbs in regulating the inflammatory microenvironment of tumours based on the concept of ‘state-target identification and treatment’: a scooping review

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