The Rôle of the Adrenal Cortex in Anoxia: The Effect of Repeated Daily Exposures to Reduced Oxygen Pressure

Eosinophil Leucocytes and Recovery from Severe Hypoxia

“…Other quantitative studies [13] have suggested that in certain circumstances at least, cortical hormones may interfere with eosinophilotactic mecha nisms, and a similar interpretation can be placed on the observations of other investigators [1,27]. Furthermore, there is evidence that the adrenal cortex has an important role in adaptation to lowered oxygen tension [28,29] and it seems likely that the marked increase in adrenal Eosinophils and Hypoxia 37 weight at day 0 (table I) indicated hyperactivity of the adrenal cortex. Others have reported both an increase in adrenal weight and a decrease in the size of the thymus [29,33] during exposure of experimental animals to lowered barometric pressures.…”

“…Furthermore, there is evidence that the adrenal cortex has an important role in adaptation to lowered oxygen tension [28,29] and it seems likely that the marked increase in adrenal Eosinophils and Hypoxia 37 weight at day 0 (table I) indicated hyperactivity of the adrenal cortex. Others have reported both an increase in adrenal weight and a decrease in the size of the thymus [29,33] during exposure of experimental animals to lowered barometric pressures. The adrenal weight has been stated to be a good index of adrenocortical activity in experiments of more than a few days duration [25], although some of the weight increase in severe hypoxia might be attributable to the greatly in creased vascularity which is known to occur in this condition [10,28].…”

Cobalt-Induced Polycythemia

“…After 3 weeks elapsed, the experimental animals manifested a paralysis of the hindquarters for about HEMOGLOBIN (GMS. PER 100 ML.BLOOD) 23 one-half hour following the injection. Accordingly, the dose was reduced to 0.1 ml.…”