The role of the anterior shoulder joint capsule in primary glenohumeral osteoarthritis

Sudah, Suleiman Y.; Menendez, Mariano E.; Moverman, Michael A.; Puzzitiello, Richard N.; Little, Dianne; Nicholson, Allen D.; Garrigues, Grant E.

doi:10.1016/j.xrrt.2022.09.005

Cited by 5 publications

(2 citation statements)

References 62 publications

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“…Eccentric glenohumeral OA is of particular concern and has been implicated as a cause of early glenoid loosening after total shoulder arthroplasty 43,44 . Several long-standing theories for the pathological development of eccentric glenoid wear have been proposed, including glenoid retroversion, muscular imbalances of the deltoid and supraspinatus, and a tight anterior capsule 45,46 . In addition, as previously described herein, it was postulated that shoulders with a shorter acromion and greater inferior glenoid inclination were at higher risk of experiencing cartilage degeneration, potentially due to greater compressive forces of the deltoid 30,47,48 .…”

Section: Glenohumeral Osteoarthritismentioning

confidence: 99%

Rotator Cuff Tears to Shoulder Instability

Testa,

Katz,

Zhang

et al. 2024

JBJS Reviews

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» The acromion is a well-studied region of the scapula that has demonstrated substantial relationships to various shoulder pathologies.» Abnormal acromial morphology is associated with rotator cuff pathology, and our understanding of this risk factor inspired acromioplasty as an adjunctive treatment for rotator cuff tears.» The acromion is linked closely to shoulder kinematics and biomechanics, as it serves as the origin for the deltoid muscle.» In degenerative shoulder disease, eccentric glenohumeral osteoarthritis has been associated with a higher, flatter acromial roof.» Increasing literature is emerging connecting morphology of the acromion with shoulder instability.

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Section: Glenohumeral Osteoarthritismentioning

confidence: 99%

Rotator Cuff Tears to Shoulder Instability

Testa,

Katz,

Zhang

et al. 2024

JBJS Reviews

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“…4 Furthermore, nonsteroidal anti-inflammatory drugs and surgical interventions are also applied to OA treatment, which have some side effects. 5 Therefore, it is necessary to identify novel molecular targets for OA pathophysiology and prevention.…”

Section: Introductionmentioning

confidence: 99%

IGF2BP1 Bolsters the Chondrocytes Ferroptosis of Osteoarthritis by Targeting m6A/MMP3 Axis

Zhao,

Dong,

Yang

et al. 2024

IJGM

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Chondrocyte degeneration and senescence are characteristics of osteoarthritis (OA) and other joint degenerative diseases, and ferroptosis has been observed to regulate the development of OA. However, the role of the N 6 -methyladenosine (m 6 A) modification in OA ferroptosis remains unclear. Methods: This study performed series of assays to investigate the function of the m 6 A reader IGF2BP1 in OA ferroptosis, including m 6 A quantitative analysis, Iron (Fe 2+ ) release analysis, Malondialdehyde (MDA) measurement, lipid peroxidation (ROS) detection and Glutathione (GSH) measurement. The molecular interaction and mechanism analysis was performed by Luciferase reporter assay, mRNA stability analysis and RNA immunoprecipitation (RIP) assay. Results: These results indicate that IGF2BP1 is upregulated in IL-1β-induced chondrocytes. Functionally, IGF2BP1 silencing represses ferroptosis, including iron (Fe 2+ ) accumulation, malondialdehyde, and reactive oxygen species (ROS). Mechanistically, among the potential downstream targets, matrix metalloproteinase-3 (MMP3) was observed to harbor a significant m 6 A modified site in the 3'-UTR. IGF2BP1 combines with MMP3 through the binding of m 6 A sites, thereby enhancing MMP3 mRNA stability. Discussion: In conclusion, our findings revealed the functions and mechanisms of m 6 A regulator IGF2BP1 in OA chondrocyte's ferroptosis, providing a novel target for OA treatment.

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CircMYO1C silencing alleviates chondrocytes inflammation and apoptosis through m⁶A/HMGB1 axis in osteoarthritis

Sun,

Chu,

Qian

et al. 2024

Biotech and App Biochem

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Circular RNAs (circRNAs) are involved in osteoarthritis (OA) progression. This study aimed to investigate the role and molecular mechanisms of circMYO1C in OA. CircMYO1C was upregulated in OA‐ and interleukin‐1β (IL‐1β)‐exposed chondrocytes. The results indicated that circMYO1C knockdown repressed the inflammatory factors (tumor necrosis factor alpha [TNF‐α], interleukin‐6 [IL‐6], interleukin‐8 [IL‐8], etc.) and apoptosis of chondrocytes following IL‐1β exposure. CircMYO1C was an N6‐methyladenosine (m6A)‐modified circRNA with m6A characteristics. High mobility group box 1 (HMGB1) was a target of circMYO1C. IL‐1β exposure increased the stability and half‐life (t1/2) of HMGB1 mRNA, while silencing circMYO1C reduced HMGB1 mRNA stability. Taken together, circMYO1C targets the m6A/HMGB1 axis to promote chondrocyte apoptosis and inflammation. The present study demonstrates that the circMYO1C/m6A/HMGB1 axis is essential for OA progression, highlighting a novel potential therapeutic target for clinical OA.

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The role of the anterior shoulder joint capsule in primary glenohumeral osteoarthritis

Cited by 5 publications

References 62 publications

Rotator Cuff Tears to Shoulder Instability

Rotator Cuff Tears to Shoulder Instability

IGF2BP1 Bolsters the Chondrocytes Ferroptosis of Osteoarthritis by Targeting m6A/MMP3 Axis

CircMYO1C silencing alleviates chondrocytes inflammation and apoptosis through m⁶A/HMGB1 axis in osteoarthritis

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The role of the anterior shoulder joint capsule in primary glenohumeral osteoarthritis

Cited by 5 publications

References 62 publications

Rotator Cuff Tears to Shoulder Instability

Rotator Cuff Tears to Shoulder Instability

IGF2BP1 Bolsters the Chondrocytes Ferroptosis of Osteoarthritis by Targeting m6A/MMP3 Axis

CircMYO1C silencing alleviates chondrocytes inflammation and apoptosis through m6A/HMGB1 axis in osteoarthritis

Contact Info

Product

Resources

About

CircMYO1C silencing alleviates chondrocytes inflammation and apoptosis through m⁶A/HMGB1 axis in osteoarthritis