The Role of the Apelin/APJ System in the Regulation of Liver Disease

Lv, Xinrui; Kong, Jing; Chen, Weidong; Wang, Yandong

doi:10.3389/fphar.2017.00221

Cited by 37 publications

(28 citation statements)

References 46 publications

(53 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…oxysporum , which is detected in the extract. Glp 1- Apelinendogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor widely expressed in the tissues of human organs [73]. The apelin is so far not reported in plant systems which need further investigation.…”

Section: Discussionmentioning

confidence: 99%

Enhancement of disease resistance, growth potential, and photosynthesis in tomato (Solanum lycopersicum) by inoculation with an endophytic actinobacterium, Streptomyces thermocarboxydus strain BPSAC147

et al. 2019

View full text Add to dashboard Cite

Biotic stresses in plants have a significant impact on agricultural productivity. In the present study, in vivo experiments were conducted to determine the physiological responses of tomato ( Solanum lycopersicum L.) seedlings by inoculation with an endophytic actinobacterium, Streptomyces thermocarboxydus isolate BPSAC147 under greenhouse conditions. Further, photochemical quantum yield of photosystem II (PSII) (F v /F m ), photochemical quenching (qP) and non-photochemical (NPQ) were calculated in seedlings inoculated with S . thermocarboxydus (T1) and were compared with control (T0) plants. Furthermore, the electron transport rate (ETR) of PSII exhibited a significant increase in T1 plants, relative to T0 plants. These results indicate that inoculation of tomato seedlings with S . thermocarboxydus had a positive effect on the process of photosynthesis, resulting in enhanced chlorophyll fluorescence parameters due to increased ETR in the thylakoid membrane. GC-MS analysis showed significant differences in the volatile compounds in the different treatments performed under greenhouse conditions. The present study suggests that S . thermocarboxydus can be used as new biocontrol agent to control Fusarium wilt in tomato crops and enhance productivity by enhancing photosynthesis.

show abstract

Section: Discussionmentioning

confidence: 99%

Enhancement of disease resistance, growth potential, and photosynthesis in tomato (Solanum lycopersicum) by inoculation with an endophytic actinobacterium, Streptomyces thermocarboxydus strain BPSAC147

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Furthermore, apelin played pivotal and various roles in the physiological and pathophysiological processes, including regulation of blood pressure, cardiac contractility, angiogenesis, metabolic balance, cell proliferation, apoptosis, and inflammation [9–12]. In addition, it has been shown that in the liver, apelin participated in hepatocyte apoptosis, glycogen synthesis, and fibrosis formation [13, 14]. A recent clinical investigation reported that serum apelin was associated with the histological and hemodynamic states of chronic liver disease [15].…”

Section: Introductionmentioning

confidence: 99%

Apelin promotes hepatic fibrosis through ERK signaling in LX-2 cells

et al. 2019

Self Cite

View full text Add to dashboard Cite

Apelin participates in cardiovascular functions, metabolic disease, and homeostasis disorder. However, the biological function of apelin in liver diseases, especially liver fibrosis is still under investigation. The present study aimed to investigate the expression of apelin in nonalcoholic fatty liver disease (NAFLD) and the mechanism of apelin promoting hepatic fibrosis through ERK signaling in hepatic stellate LX-2 cells. The results showed that the ALT and AST levels in serum were increased in the mice fed HFC. The histological staining revealed that hepatocellular steatosis and ballooning degeneration was severe, and fibrogenesis appeared as increased pericellular collagen deposition along with pericentral (lobular) collagen deposition in the mice fed HFC. Immunochemistry and qRT-PCR results showed that the expression of apelin and profibrotic genes was higher as compared to the control group. The in vitro experiments demonstrated that apelin-13 upregulated the transcription and translation levels of collagen type I (collagen-I) and α-smooth muscle actin (α-SMA) in LX-2 cells. The immunofluorescent staining, qRT-PCR, and Western blot results showed that the overexpression of apelin markedly increased the expression of α-SMA and cyclinD1. The LX-2 cells treated with apelin-13 displayed an increased expression of pERK1/2 in a time-dependent manner, while the pretreatment with PD98059 abolished the apelin-induced expression of α-SMA and cyclinD1. Furthermore, the in vivo and in vitro assays suggested a key role of apelin in promoting liver fibrosis, and the underlying mechanism might be ascribed to the apelin expression of profibrotic genes via ERK signaling pathway.Electronic supplementary materialThe online version of this article (10.1007/s11010-019-03581-0) contains supplementary material, which is available to authorized users.

show abstract

“…Furthermore, the apelin-APJ axis promotes liver inflammation and fibrosis mainly through elevated expression of collagen-II and platelet-derived growth factor receptor β (PDGFRβ) that can explain rather detrimental then protective role of apelin over- expression found in the present study [26]. In the liver, the apelin/APJ system may participate in the formation of hepatic fibrosis or cirrhosis by inhibiting liver regeneration and promoting Fas-induced apoptosis [27]. Nonetheless, anti-apoptotic effects of apelin on vascular smooth muscle cells have also been observed [28].…”

Section: Resultsmentioning

confidence: 52%

Vitamin D(3) regulates hepatic VEGF-A and apelin expression in experimental type 1 diabetes

Labudzynskyi¹,

Shymanskyi²,

Lisakovska³

et al. 2020

Ukr.Biochem.J

View full text Add to dashboard Cite

The deficiency of vitamin D is associated with the risk of various chronic diseases, including diabetes mellitus and its complications. Given the strong genomic action of vitamin D hormone-active form, its deficiency can lead to dysfunction of cytokine signaling pathways, including those dependent on vascular endothelial growth factors (VEGFs) and apelin. The present study was carried out to define the link between VEGF-A and apelin expression in liver, hepatocytes viability and vitamin D status at experimental type 1 diabetes in mice. We established that chronic hyperglycemia at streptozotocin-induced diabetes was accompanied by a 2.2-fold decrease in 25OHD content in the serum and increased hepatocytes apoptosis and necrosis. Vitamin D deficiency correlated with increased apelin and VEGF-A (8-and 1.6-fold respectively) expression. Almost complete restoration of circulatory 25OHD content in serum was achieved at vitamin D 3 treatment (800 IU/kg, per os, for 2 months) followed by reduced apelin and VEGF-A expression in liver and the decline of hepatocytes apoptosis. We conclude that vitamin D 3 can be involved in cell survival, angiogenesis and fibrogenesis by modulating VEGF-A and apelin dependent regulatory systems in diabetic liver.

show abstract

The Role of the Apelin/APJ System in the Regulation of Liver Disease

Cited by 37 publications

References 46 publications

Enhancement of disease resistance, growth potential, and photosynthesis in tomato (Solanum lycopersicum) by inoculation with an endophytic actinobacterium, Streptomyces thermocarboxydus strain BPSAC147

Enhancement of disease resistance, growth potential, and photosynthesis in tomato (Solanum lycopersicum) by inoculation with an endophytic actinobacterium, Streptomyces thermocarboxydus strain BPSAC147

Apelin promotes hepatic fibrosis through ERK signaling in LX-2 cells

Vitamin D(3) regulates hepatic VEGF-A and apelin expression in experimental type 1 diabetes

Contact Info

Product

Resources

About