The role of the autophagy in myocardial ischemia/reperfusion injury

Ma, Sai; Wang, Yabin; Chen, Yundai; Cao, Feng

doi:10.1016/j.bbadis.2014.05.010

Cited by 267 publications

(218 citation statements)

References 46 publications

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“…As in AF, failure of proteostasis is also implicated in development of HF owing to myocardial infarction or valvular disease. As is evident in genetic forms of cardiomyopathies, derailed proteostasis has been suggested to contribute to the pathogenesis of acquired cardiomyopathies [131][132][133] . Myocardial samples from patients with myocardial infarction or atrial pressure overload owing to mitral valve disease reveal a substantial amount of myolysis and autophagosomes, indicating derailment of proteostasis (FIG.…”

Section: Derailment Owing To Environmental Stressmentioning

confidence: 99%

Proteostasis in cardiac health and disease

Henning

Brundel²

2017

Nat Rev Cardiol

144

126

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The worldwide increase in life expectancy gives rise to an increasing prevalence of cardiac diseases, which remain the leading cause of disability and death in the developed world [1][2][3] . Currently, the mechanisms under lying how ageing contributes to the initiation or acceler ation of cardiac diseases are essentially unresolved. Prevailing theories of ageing centre on gradual derail ment of cellular protein homeostasis -proteostasis -either by design (genetically) or by 'wear and tear' (environmentally) 3 . Central to the role of proteostasis derailment as a major factor in ageing is the observation that protein function declines over time.Proteins are the most versatile and complex macro molecules and are involved in the proper functioning of every biological process 4 . After synthesis as a poly peptide chain from the genetic code, proper function of a protein relies heavily on its correct folding into a 3D native state and on various post translational modifi cations, mostly involving the addition of chem ical groups (including phosphate, acetate, and carbo hydrate). Protein maturation, transport, and ultimately breakdown is monitored and supported by various classes of proteins, collectively called 'protein quality control' (PQC) [3][4][5] . Balanced proteostasis, therefore, depends on proper PQC and is crucial for cellular and organismal health 6 . The intricate network making up the PQC involves numerous proteins, of which the main players are the chaperones and their regula tors 4,7-9 (assisting in folding and refolding of proteins) and the pathways that clear irreversibly misfolded and aggregation prone proteins (the ubiquitin-proteasome system [UPS] and autophagy systems) 9-11 . With ageing, the gradual accumulation of misfolded or damaged pro teins, together with concomitant failure of PQC, results in proteotoxic stress and compromised defence against reactive oxygen species (ROS) 10 , a process that is likely to be accelerated in various age related diseases includ ing neurodegenerative diseases 12,13 , type 2 diabetes mel litus 14 , cancer 15 , and cardiac diseases [16][17][18][19][20] . In addition to the accumulation of misfolded proteins, ageing is accompanied by an imbalance in the proteome, as indi cated by lowered expression of chaperone, proteaso mal, ribosomal, and mitochondrial proteins, whereas proteins related to oxidative stress are upregulated 21,22 . Although mild impairment of proteostasis extends lifespan in Caenorhabditis elegans, referred to as hormesis, sustained impairment is accompanied by loss of PQC to neutralize this effect 3,5 . Importantly, evidence indicates that the amount of soluble, aggregate prone protein oligomers, rather than the abundance of pro tein aggregates, correlates with disease severity 23,24 . Therefore, protein aggregates, which contain both misfolded proteins and elevated levels of chaper ones, constitute an adequate PQC response, aimed at sequestering potentially harmful protein oligomers, rather than embodying the ultimate cellular threat 25 . This ...

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Section: Derailment Owing To Environmental Stressmentioning

confidence: 99%

Proteostasis in cardiac health and disease

Henning

Brundel²

2017

Nat Rev Cardiol

144

126

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“…The overexpression of Beclin-1 subsequently provokes autophagy in response. The antioxidant MPG significantly reduced Beclin-1 upregulation, also pointing to the potential role of ROS in activating Beclin-1 (Hamacher-Brady et al, 2007;Ma et al, 2015). Another study demonstrated that pretreatment with U0126, an ERK kinase inhibitor, markedly reduced the level of Beclin-1 and LC3, and suppressed reperfusion-induced autophagy (Fig.…”

Section: Detrimental Effects Of Autophagy In Reperfusion Injurymentioning

confidence: 71%

“…The cardioprotective effect HERBAL MEDICINE MODULATES AUTOPHAGY IN ISCHEMIAof Urocortin was mediated by reducing Beclin-1 expression to reduce autophagic activity, which is dependent on the PI3K/Akt pathway (Valentim et al, 2006). As discussed above, ischemia stimulated autophagy is mediated via the AMPK-dependent pathway; whereas, in the reperfusion phase, autophagy is activated by the modulation of Beclin-1 and BNIP3 (Hamacher-Brady et al, 2007;Ma et al, 2015). Beclin-1 is important in triggering reperfusion-activated autophagy.…”

Section: Detrimental Effects Of Autophagy In Reperfusion Injurymentioning

confidence: 96%

Roles of Autophagy in Ischemic Heart Diseases and the Modulatory Effects of Chinese Herbal Medicine

et al. 2017

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Autophagy is an evolutionarily conserved degradation process which eliminates dysfunctional proteins and cytoplasmic components to maintain homeostasis for cell survival. Increasing evidence has demonstrated the modulatory role of autophagy in ischemic heart diseases (IHDs). Traditionally, this process has been recognized as having protective functions, such as inhibiting atherosclerosis progression and reducing cell death during the ischemic phase. However, recent studies have suggested its dual roles in myocardial ischemia/reperfusion (MIR) injury. Excessive autophagy may play a deleterious role in cardiac function, due to overwhelming clearance of cellular constituents and proteins. Hence modulation of autophagy to increase cardiomyocyte survival and improve cardiac function is meaningful for the treatment of IHD. Chinese herbal medicine, including extractive compounds and patented drugs, has shown its potential role in treating IHD by addressing autophagy-related mechanisms. This review summarizes the updated knowledge on the molecular basis and modulatory role of autophagy in IHD and the recent progress of Chinese herbal medicine in its treatment.

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“…Sai Ma et al demonstrate that autophagy plays distinct roles in myocardial I/R injury [19]. During myocardial ischemia phase, autophagy plays a protective effect, while it is detrimental in the reperfusion phase.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Polyphenol Extracts from Sea Buckthorn (<i>Hippopha&#235 rhamnoides</i> L.) on Rat Hearts

Tang¹,

Lv²,

Li³

et al. 2016

OJMIP

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The objective of present study was to investigate the antioxidative and cardioprotective effects of polyphenol extracts from sea buckthorn (PESB) against myocardial ischemia reperfusion injury (MIRI). PESB was analyzed using HPLC-DAD and their antioxidant activities were evaluated by measuring the intrinsic free radicals cavenging capacity and inhibiting the formation of hydroxyl radical capacity. Experiments on the isolated rat hearts were carried out according to the improved Langendorff retrograde perfusion technology. Coronary effluent of lactate dehydrogenase (LDH) and creatine kinase isoenzyme (CK-MB) activities were analyzed to determine the extent of myocardial injury. Protein expression levels of Beclin-1, microtubule-associated protein 1 light chain 3 (LC3) I and II were measured to evaluate the degree of autophagy. In conclusion, coupled results from both in vivo and in vitro experiments have confirmed that PESB has potential health implications in both prevention and amelioration of MIRI, which may be attributed to the inhibition of autophagy.

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The role of the autophagy in myocardial ischemia/reperfusion injury

Cited by 267 publications

References 46 publications

Proteostasis in cardiac health and disease

Proteostasis in cardiac health and disease

Roles of Autophagy in Ischemic Heart Diseases and the Modulatory Effects of Chinese Herbal Medicine

Protective Effects of Polyphenol Extracts from Sea Buckthorn (<i>Hippopha&#235 rhamnoides</i> L.) on Rat Hearts

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The role of the autophagy in myocardial ischemia/reperfusion injury

Cited by 267 publications

References 46 publications

Proteostasis in cardiac health and disease

Proteostasis in cardiac health and disease

Roles of Autophagy in Ischemic Heart Diseases and the Modulatory Effects of Chinese Herbal Medicine

Protective Effects of Polyphenol Extracts from Sea Buckthorn (&lt;i&gt;Hippopha&amp;#235 rhamnoides&lt;/i&gt; L.) on Rat Hearts

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Protective Effects of Polyphenol Extracts from Sea Buckthorn (<i>Hippopha&#235 rhamnoides</i> L.) on Rat Hearts