The Role of the Basal Forebrain in Episodic Memory Retrieval: A Positron Emission Tomography Study

Fujii, Toshikatsu; Okuda, Jun; Tsukiura, Takashi; Ohtake, Hiroto; Miura, Rina; Fukatsu, Reiko; Suzuki, Kyoko; Kawashima, Ryuta; Itoh, Masatoshi; Fukuda, Hiroshi; Yamadori, Atsushi

doi:10.1006/nimg.2001.0995

Cited by 79 publications

(27 citation statements)

References 38 publications

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“…Some studies have suggested that, in certain contexts, the HF contributes to the reduced attention to irrelevant events rather than the increased attention to relevant events (Han et al, 1995), which is different from what we proposed above (i.e., attention for learning). Notably, this alternative function of the HF may be guided by cholinergic neurons in the mBF (Chiba et al, 1995;Baxter et al, 1997;Oros et al, 2014).…”

Section: Discussioncontrasting

confidence: 99%

“…Lesion and brain imaging studies have linked the mBF to learning and memory functions (Damasio et al, 1985;Ridley et al, 1988Ridley et al, , 1989Ridley et al, , 1999aMorris et al, 1992;Roman et al, 1993;Abe et al, 1998;De Rosa and Hasselmo, 2000;Fujii et al, 2002;De Rosa et al, 2004;Baxter and Bucci, 2013;Iglesias et al, 2013). Anatomically, the mBF is shown to project to brain areas that are heavily involved in learning and memory, including the HF and the anterior cingulate cortex (Mesulam et al, 1983).…”

Section: Discussionmentioning

confidence: 99%

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Neurons in the Primate Medial Basal Forebrain Signal Combined Information about Reward Uncertainty, Value, and Punishment Anticipation

2015

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It has been suggested that the basal forebrain (BF) exerts strong influences on the formation of memory and behavior. However, what information is used for the memory-behavior formation is unclear. We found that a population of neurons in the medial BF (medial septum and diagonal band of Broca) of macaque monkeys encodes a unique combination of information: reward uncertainty, expected reward value, anticipation of punishment, and unexpected reward and punishment. The results were obtained while the monkeys were expecting (often with uncertainty) a rewarding or punishing outcome during a Pavlovian procedure, or unexpectedly received an outcome outside the procedure. In vivo anterograde tracing using manganese-enhanced MRI suggested that the major recipient of these signals is the intermediate hippocampal formation. Based on these findings, we hypothesize that the medial BF identifies various contexts and outcomes that are critical for memory processing in the hippocampal formation.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Neurons in the Primate Medial Basal Forebrain Signal Combined Information about Reward Uncertainty, Value, and Punishment Anticipation

2015

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“…The latter finding is particularly interesting because it would indicate that these brain areas are not only involved in the retrieval of time-contextual information but also in episodic context binding (cf. De Rosa, Desmond, Anderson, Pfefferbaum, & Sullivan, 2004;Fujii et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Episodic context binding in task switching: Evidence from amnesia

et al. 2013

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The purpose of the present study was to investigate whether amnesic patients show a bivalency effect. The bivalency effect refers to the performance slowing that occurs when switching tasks and bivalent stimuli appear occasionally among univalent stimuli. According to the episodic context binding account, bivalent stimuli create a conflict-loaded context that is re-activated on subsequent trials and thus it is assumed that it depends on memory binding processes. Given the profound memory deficit in amnesia, we hypothesized that the bivalency effect would be largely reduced in amnesic patients. We tested sixteen severely amnesic patients and a control group with a paradigm requiring predictable alternations between three simple cognitive tasks, with bivalent stimuli occasionally occurring on one of these tasks. The results showed the typical bivalency effect for the control group, that is, a generalized slowing for each task. In contrast, for amnesic patients, only a short-lived slowing was present on the task that followed immediately after a bivalent stimulus, indicating that the binding between tasks and context was impaired in amnesic patients.

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“…24 The frontal cortex is also important in episodic memory, especially in information recall with time. 25 Addressing complex cognitive problems involves not only the frontal lobe itself but also the frontal lobe function network, 26 with connectivity between the frontal lobe and hippocampus likely to sustain executive control functions. 27 The hippocampus-prefrontal lobe circuit is the key neural circuit in working memory: 28,29 cognitive training can increase RS FC between the frontal lobe and other areas of the working memory and executive control networks in patients with multiple sclerosis.…”

Section: Groupmentioning

confidence: 99%

Analysis of central mechanism of cognitive training on cognitive impairment after stroke: Resting-state functional magnetic resonance imaging study

et al. 2014

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Objective: To investigate the central mechanism of cognitive training in patients with stroke, using resting state (RS) functional magnetic resonance imaging (fMRI). Methods: Patients with stroke and executive function and memory deficit were randomized to receive computer-assisted cognitive training (treatment group; total 60 h training over 10 weeks) or no training (control group). All participants received neuropsychological assessment and RS fMRI at baseline and 10 weeks. Results: Patients in the treatment group (n ¼ 16) showed increased functional connectivity (FC) of the hippocampus with the frontal lobe (right inferior, right middle, left middle, left inferior and left superior frontal gyrus) and left parietal lobe at 10 weeks compared with baseline. Patients in the control group (n ¼ 18) showed decreased FC of the left hippocampus-right occipital gyrus, and right hippocampus-right posterior lobe of cerebellum and left superior temporal gyrus. Significant correlations were found between improved neuropsychological scores and increased FC of the hippocampus with the frontal lobe and left parietal lobe in the treatment group only. Conclusions: Increased RS FC of the hippocampus with the frontal and parietal lobes may be an important mechanism of cognitive recovery after stroke.

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The Role of the Basal Forebrain in Episodic Memory Retrieval: A Positron Emission Tomography Study

Cited by 79 publications

References 38 publications

Neurons in the Primate Medial Basal Forebrain Signal Combined Information about Reward Uncertainty, Value, and Punishment Anticipation

Neurons in the Primate Medial Basal Forebrain Signal Combined Information about Reward Uncertainty, Value, and Punishment Anticipation

Episodic context binding in task switching: Evidence from amnesia

Analysis of central mechanism of cognitive training on cognitive impairment after stroke: Resting-state functional magnetic resonance imaging study

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