“…In COVID-19 patients, neutrophilia associated with lymphopenia was observed in patients with increased disease severity and with poor prognosis ( Picchi et al, 2021 , Yang et al, 2020 , Zhu et al, 2021 ). A number of studies showed a correlation between markers derived from standard blood count tests, such as neutrophil-to-lymphocyte ratio (NLR), derived NLR ratio (dNLR, neutrophil count divided by the result of WBC count minus neutrophil count), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) and systematic inflammatory response in a number of age-related diseases, including cancer ( Xu et al, 2021 , Ying et al, 2014 ), type 2 diabetes mellitus (T2DM) ( Tong et al, 2004 ), cardiovascular diseases (CVD) ( Bhat et al, 2013 , Ji et al, 2021 ), and stroke ( Cai et al, 2021a ).…”