The Role of the Bone Marrow Microenvironment in the Response to Infection

Johnson, Carol; Zhang, Jizhou; Lucas, Daniel

doi:10.3389/fimmu.2020.585402

Cited by 23 publications

(16 citation statements)

References 76 publications

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“…In addition to physical and non-hematopoietic elements, several hematopoietic cells in the BM influence the behavior of HSC: for example, megakaryocytes are physically associated with HSCs, regulating their quiescence or proliferation [ 31 ], macrophages participate in the regulation of HSC release into the circulation [ 32 ] and dendritic cells control HSC trafficking by regulation of sinusoidal vascular permeability [ 33 ].…”

Section: The Pre-leukemic Cell and Its Interaction With The Microenvironmentmentioning

confidence: 99%

The Bone Marrow Niche in B-Cell Acute Lymphoblastic Leukemia: The Role of Microenvironment from Pre-Leukemia to Overt Leukemia

Dander

Palmi

D’Amico

et al. 2021

IJMS

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Genetic lesions predisposing to pediatric B-cell acute lymphoblastic leukemia (B-ALL) arise in utero, generating a clinically silent pre-leukemic phase. We here reviewed the role of the surrounding bone marrow (BM) microenvironment in the persistence and transformation of pre-leukemic clones into fully leukemic cells. In this context, inflammation has been highlighted as a crucial microenvironmental stimulus able to promote genetic instability, leading to the disease manifestation. Moreover, we focused on the cross-talk between the bulk of leukemic cells with the surrounding microenvironment, which creates a “corrupted” BM malignant niche, unfavorable for healthy hematopoietic precursors. In detail, several cell subsets, including stromal, endothelial cells, osteoblasts and immune cells, composing the peculiar leukemic niche, can actively interact with B-ALL blasts. Through deregulated molecular pathways they are able to influence leukemia development, survival, chemoresistance, migratory and invasive properties. The concept that the pre-leukemic and leukemic cell survival and evolution are strictly dependent both on genetic lesions and on the external signals coming from the microenvironment paves the way to a new idea of dual targeting therapeutic strategy.

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Section: The Pre-leukemic Cell and Its Interaction With The Microenvironmentmentioning

confidence: 99%

The Bone Marrow Niche in B-Cell Acute Lymphoblastic Leukemia: The Role of Microenvironment from Pre-Leukemia to Overt Leukemia

Dander

Palmi

D’Amico

et al. 2021

IJMS

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“…Examples of this plasticity include hemorrhage which triggers emergency red blood cell production and infection which -depending on the infectious agent- can trigger emergency neutrophil, monocyte, and/or dendritic cell production. The bone marrow microenvironment plays critical roles in both sensing and orchestrating the progenitor response to infection [reviewed in ( 60 )]. Importantly, inflammation and infection also profoundly remodel the sinusoidal network and perivascular stromal cells that maintain hematopoiesis and perturb stem cell localization within the marrow ( 60 ).…”

Section: Open Questions and Future Developmentsmentioning

confidence: 99%

“…The bone marrow microenvironment plays critical roles in both sensing and orchestrating the progenitor response to infection [reviewed in ( 60 )]. Importantly, inflammation and infection also profoundly remodel the sinusoidal network and perivascular stromal cells that maintain hematopoiesis and perturb stem cell localization within the marrow ( 60 ). Key open questions are a) whether hematopoietic stress responses use the same anatomical structures as normal hematopoiesis or instead depend on stress-specific anatomical cues and b) to what extend remodeling of sinusoids perturbs the anatomical structures that maintain the different progenitors.…”

Section: Open Questions and Future Developmentsmentioning

confidence: 99%

Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to?

Zhang

Lucas

2021

Front. Immunol.

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The shape and spatial organization -the anatomy- of a tissue profoundly influences its function. Knowledge of the anatomical relationships between parent and daughter cells is necessary to understand differentiation and how the crosstalk between the different cells in the tissue leads to physiological maintenance and pathological perturbations. Blood cell production takes place in the bone marrow through the progressive differentiation of stem cells and progenitors. These are maintained and regulated by a heterogeneous microenvironment composed of stromal and hematopoietic cells. While hematopoiesis has been studied in extraordinary detail through functional and multiomics approaches, much less is known about the spatial organization of blood production and how local cues from the microenvironment influence this anatomy. Here, we discuss some of the studies that revealed a complex anatomy of hematopoiesis where discrete local microenvironments spatially organize and regulate specific subsets of hematopoietic stem cells and/or progenitors. We focus on the open questions in the field and discuss how new tools and technological advances are poised to transform our understanding of the anatomy of hematopoiesis.

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“…T he adult bone marrow is a reservoir of stem cells essential for tissue repair and regeneration. (1)(2)(3) The stem cells can selfrenew and differentiate into multiple mature cell types. Bone marrow stem cells include hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs).…”

Section: Introductionmentioning

confidence: 99%

Enzyme‐Cleaved Bone Marrow Transplantation Improves the Engraftment of Bone Marrow Mesenchymal Stem Cells

Kawai

Takabatake

et al. 2023

JBMR Plus

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Mesenchymal stem cell (MSC) therapy is a promising approach to curing bone diseases and disorders. In treating genetic bone disorders, MSC therapy is local or systemic transplantation of isolated and in vitro proliferated MSC rather than bone marrow transplantation. Recent evidence showed that bone marrow MSC engraftment to bone regeneration has been controversial in animal and human studies. Here, our modified bone marrow transplantation (BMT) method solved this problem. Like routine BMT, our modified method involves three steps: (i) isolation of bone marrow cells from the donor, (ii) whole‐body lethal irradiation to the recipient, and (iii) injection of isolated bone marrow cells into irradiated recipient mice via the tail vein. The significant modification is imported at the bone marrow isolation step. While the bone marrow cells are flushed out from the bone marrow with the medium in routine BMT, we applied the enzymes’ (collagenase type 4 and dispase) integrated medium to wash out the bone marrow cells. Then, cells were incubated in enzyme integrated solution at 37°C for 10 minutes. This modification designated BMT as collagenase‐integrated BMT (c‐BMT). Notably, successful engraftment of bone marrow MSC to the new bone formation, such as osteoblasts and chondrocytes, occurs in c‐BMT mice, whereas routine BMT mice do not recruit bone marrow MSC. Indeed, flow cytometry data showed that c‐BMT includes a higher proportion of LepR+, CD51+, or RUNX2+ non‐hematopoietic cells than BMT. These findings suggested that c‐BMT is a time‐efficient and more reliable technique that ensures the disaggregation and collection of bone marrow stem cells and engraftment of bone marrow MSC to the recipient. Hence, we proposed that c‐BMT might be a promising approach to curing genetic bone disorders. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.

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The Role of the Bone Marrow Microenvironment in the Response to Infection

Cited by 23 publications

References 76 publications

The Bone Marrow Niche in B-Cell Acute Lymphoblastic Leukemia: The Role of Microenvironment from Pre-Leukemia to Overt Leukemia

The Bone Marrow Niche in B-Cell Acute Lymphoblastic Leukemia: The Role of Microenvironment from Pre-Leukemia to Overt Leukemia

Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to?

Enzyme‐Cleaved Bone Marrow Transplantation Improves the Engraftment of Bone Marrow Mesenchymal Stem Cells

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