The Role of the Brain–Gut–Microbiome in Mental Health and Mental Disorders

Treisman, G.J.

doi:10.1016/b978-0-12-804024-9.00042-2

Cited by 2 publications

(5 citation statements)

References 54 publications

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“…Scientific progress has rehashed old concepts about the brain and mental health and specifically the concept that mental health is not only related to the brain but is also related to the gut microbiota [73]. In recent years, potential effects of microbiota products on the brain have been demonstrated either directly by producing regulatory hormones or neurotransmitters or indirectly by affecting the gastrointestinal tract, autonomic nervous system, or intestinal nervous system or by stimulating the immune system [17].…”

Section: The Microbiota and Psychiatric Disordersmentioning

confidence: 99%

“…Production of serotonin was also observed by Candida, Streptococcus, Escherichia, and Enterococcus. This hormone is responsible for regulating mood, appetite, and sleep, in addition to its role in stimulating memory and learning [17].…”

Section: The Microbiota and Psychiatric Disordersmentioning

confidence: 99%

“…The subtleties knowledge of our microbiota has led us to reconsider the factors that control human behavior. That our behavior is not only shaped by our genes and their interactions with the environment it is also shaped by our microbiota, their genes, and interactions with their environment that is, with us [17].…”

Section: The Microbiota and Psychiatric Disordersmentioning

confidence: 99%

“…Gut microbiota dysbiosis leads to many diseases [16], like auto-immunity diseases such as asthma and arthritis [4], chronic diseases such as inflammatory bowel disease (IBD), and metabolic and cardiovascular diseases like obesity, diabetes, atherosclerosis [7], and liver diseases [8]. The consequences of microbiota dysbiosis can extend to as far as cancer and psychological diseases like depression, anxiety, autism, and Alzheimer's disease [17].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Interaction of the microbiota with the human body in health and diseases

Altveş

Yıldız

Vural

2020

Bioscience of Microbiota, Food and Health

312

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The human body contains many microorganisms, including a large number of bacteria, viruses, fungi, and protozoa, which are referred to as the microbiota. Compared with the number of cells comprising the human body, that of the microbiota has been found to be much larger. The microbiome is defined as microorganisms and their genomes have been shown to contain about 100 times more genes than the human genome. The microbiota affects many vital functions in the human body. It contributes to regulation of the immune system, digestion of food, production of vitamins such as B12 and K, metabolization of xenobiotic materials, and many other tasks. Many factors affect the microbiota biodiversity, such as diet, medicines including antibiotics, relationships with the environment, pregnancy, and age. Studies have shown that the lack of microbiota diversity leads to many diseases like autoimmune diseases such as diabetes type I, rheumatism, muscular dystrophy, problems in blood coagulation due to lack of vitamin K, and disturbances in the transfer of nerve cells due to lack of vitamin B12, in addition to its involvement in a number of conditions such as cancer, memory disorders, depression, stress, autism, and Alzheimer's disease. The aim of this review is to summarize the latest studies discussing the relationship between the microbiota and the human body in health and diseases.

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Section: The Microbiota and Psychiatric Disordersmentioning

confidence: 99%

Section: The Microbiota and Psychiatric Disordersmentioning

confidence: 99%

Section: The Microbiota and Psychiatric Disordersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Interaction of the microbiota with the human body in health and diseases

Altveş

Yıldız

Vural

2020

Bioscience of Microbiota, Food and Health

312

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“…As the etiology of IBD is not fully understood, it is believed that the interaction among genetic, immunological, and environmental factors, such as intestinal microbiota, can trigger the disease. Chronic gut dysbiosis has also been associated with autoimmune diseases such as eczema, asthma, celiac disease, and type-1 diabetes, as well as with diseases related to the consumption of an unbalanced diet, increased inactivity, age, obesity, type 2 diabetes, metabolic and cardiovascular diseases [ 14 , 15 ], liver disorders such as non-alcoholic liver steatosis [ 16 ], cancers such as colorectal cancer, and psychological diseases such as depression, anxiety, autism and Alzheimer’s disease [ 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Intestinal Microbiota and miRNA in IBD: A Narrative Review about Discoveries and Perspectives for the Future

Oliveira

Quaglio

Magro

et al. 2023

IJMS

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Inflammatory bowel disease (IBD) includes Crohn’s disease (CD) and ulcerative colitis (UC) and comprises a chronic gastrointestinal tract disorder characterized by hyperactive and dysregulated immune responses to environmental factors, including gut microbiota and dietary components. An imbalance of the intestinal microbiota may contribute to the development and/or worsening of the inflammatory process. MicroRNAs (miRNAs) have been associated with various physiological processes, such as cell development and proliferation, apoptosis, and cancer. In addition, they play an important role in inflammatory processes, acting in the regulation of pro- and anti-inflammatory pathways. Differences in the profiles of miRNAs may represent a useful tool in the diagnosis of UC and CD and as a prognostic marker in both diseases. The relationship between miRNAs and the intestinal microbiota is not completely elucidated, but recently this topic has gained prominence and has become the target of several studies that demonstrate the role of miRNAs in the modulation of the intestinal microbiota and induction of dysbiosis; the microbiota, in turn, can regulate the expression of miRNAs and, consequently, alter the intestinal homeostasis. Therefore, this review aims to describe the interaction between the intestinal microbiota and miRNAs in IBD, recent discoveries, and perspectives for the future.

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The Role of the Brain–Gut–Microbiome in Mental Health and Mental Disorders

Cited by 2 publications

References 54 publications

Interaction of the microbiota with the human body in health and diseases

Interaction of the microbiota with the human body in health and diseases

Intestinal Microbiota and miRNA in IBD: A Narrative Review about Discoveries and Perspectives for the Future

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