The role of the CD95, CD38 and TGFβ1 during active human cytomegalovirus infection in liver transplantation

Prolonged Cold Ischemia Does Not Trigger Lethal Rejection or Accelerate the Acute Rejection in Two Allogeneic Rat Liver Transplantation Models

“…CD28 is a co-stimulatory molecule, which is essential for priming T cell activation [15,35]. CD38 was also previously reported as an activation marker of T cell or CD8þ T cells [36,37]. After prolonged CI, the mRNA expression of CD25, CD28, and CD38 were up-regulated, whereas the mRNA expression of Foxp3 was not affected, implying an enhanced allogeneic immune response.…”

Is HCMV a tumor promoter?

“…As previously noted, TGF-beta, IL-10 and PGE-2 are among the most potent immunosuppressive cytokines. These cytokines are all induced by HCMV infected cells, and in combination would be expected to have a profound immunosuppressive effect on the host antitumor response (Maussang et al, 2009; Wang et al, 2006; Zhu et al, 2002). …”

Monitoring of CD95 and CD38 expression in peripheral blood T lymphocytes during active human cytomegalovirus infection after orthotopic liver transplantation

“…Numbers of CD38 molecules expressed on CD8 + T cells represent the levels of activated T lymphocytes. The diagnostic application of CD38 suggests strongly that quantification of CD38 molecules increases the diagnostic value of this marker 8,14 . McCloskey et al .…”

“…Flow cytometric enumeration of lymphocytes subsets provides important data on the immune status of HCMV‐infected individuals 14 . The QuantiBRITE bead method (BIOCYTEX, Marseille, France) may provide reliable results that are comparable to relatively good interlaboratory comparability of results.…”