The Role of the Central Nervous System in the Inhibition of Postcastration Syndrome in Cervical Cancer Patients of Reproductive Age Based on Programmable Xenon Therapy Regimens

Abstract

The aim was to study the possibility of normalizing rhythmic brain activity and psychoemotional status in young patients with locally advanced cervical cancer after surgical castration and the development of severe postovariectomic syndrome using low dose xenon therapy regimens. Material and methods. The study included data obtained from 30 patients aged 39.4±3.7 years with cervical cancer pT1bN0M0 (n=14), pT2aN0M0 (n=16); after the extirpation of the uterus with appendages and the upper third of the vagina with pelvic lymphadenectomy, patients received low-dose xenon therapy in an exponential programmed regimen of xenon concentration and exposure. The state of brain rhythms was controlled using the electroencephalograph-recorder “En-cephalan EEGR-19/26”. 19 unipolar leads were recorded with the calculation of the EEG spectral power and topographical mapping using the Encephalan-3D program. Psychological testing of patients with cervical cancer was performed using the questionnaires of 7-point individual subjective self-assessment developed by Garkavi L.Kh.- KuzmenkoT.S. Results. The normalizing effect of xenon therapy involved restructuring of cortical brain activity with a decrease in the power of slow- and high-frequency alpha-rhythm subranges and the predominance of physiologically significant mid-frequency alpha rhythms of 9.6 Hz quiet wakefulness together with slow delta and theta ranges. This correlated with the data of topographic mapping of the power spectrum on the presence of two foci of the spatial organization of alpha and theta rhythms. Evaluation criteria for psychological testing showed the reduction of anxiety, depression, fatigue, normalization of sleep, appetite, work capacity, and increased activity and optimism in 82-98% of patients. Conclusion. The possibility of inhibiting the postcastration syndrome in patients with cervical cancer is evidently realized through the xenon-induced effect of brain rhythmogenesis restructuring, leading to the normalization of impaired cortical-subcortical relationships and the formation of positive psycho-emotional status. The therapeutic expediency of low-dose xenon therapy for oncogynecological patients is determined by a significant correction of the state of the CNS state and the early achievement of functional and social rehabilitation.