The Role of the Cerebellum in Pain Perception: A Brain SPECT Perfusion Study in Patients with Burn Injuries

Bermo, Mohammed; Zacharias, Claudia; Patterson, David R.; Wilson, Ann; Sharar, Sam R.; Minoshima, Satoshi; Hoffman, Hunter G.; Lewis, David H.

doi:10.1111/jon.12759

Cited by 8 publications

(31 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that the parietal association area and the prefrontal cortex are involved in the processing of thermal pain and are related to cognitive factors such as memory or stimulus evaluation (Strigo et al, 2003). Subcortical activation has also been reported, most notably in the ventroposterolateral (VPL) and ventroposteromedial (VPM) nuclei in the thalamus (Sanganahalli et al, 2022), basal ganglia (Raver et al, 2020), and cerebellum (Bermo et al, 2020). It has been known that the amygdala is also central to the emotional processing of sensory stimuli, including pain (Gandhi et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Diffusion tensor imaging reveals sex differences in pain sensitivity of rats

Cha

Eum²,

Kim³

et al. 2023

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Studies on differences in brain structure and function according to sex are reported to contribute to differences in behavior and cognition. However, few studies have investigated brain structures or used tractography to investigate gender differences in pain sensitivity. The identification of tracts involved in sex-based structural differences that show pain sensitivity has remained elusive to date. Here, we attempted to demonstrate the sex differences in pain sensitivity and to clarify its relationship with brain structural connectivity. In this study, pain behavior test and brain diffusion tensor imaging (DTI) were performed in male and female rats and tractography was performed on the whole brain using fiber tracking software. We selected eight brain regions related to pain and performed a tractography analysis of these regions. Fractional anisotropy (FA) measurements using automated tractography revealed sex differences in the anterior cingulate cortex (ACC)-, prefrontal cortex (PFC)-, and ventral posterior thalamus-related brain connections. In addition, the results of the correlation analysis of pain sensitivity and DTI tractography showed differences in mean, axial, and radial diffusivities, as well as FA. This study revealed the potential of DTI for exploring circuits involved in pain sensitivity. The behavioral and functional relevance’s of measures derived from DTI tractography is demonstrated by their relationship with pain sensitivity.

show abstract

Section: Discussionmentioning

confidence: 99%

Diffusion tensor imaging reveals sex differences in pain sensitivity of rats

Cha

Eum²,

Kim³

et al. 2023

Front. Mol. Neurosci.

View full text Add to dashboard Cite

show abstract

“…18 Furthermore, a study by Bermo et al showed increased perfusion of the cerebellum in patients undergoing painful burn wound cleaning and debridement. 19 Lastly, Newberg et al also noted asymmetric thalamic perfusion in postoperative dental pain that improved after analgesia was administered. 20 Aside from brain perfusion measurements, SPECT has been used to help localize pain in the periphery.…”

Section: Review Single-photon Emission Computed Tomography Imagingmentioning

confidence: 99%

Radiotracers in the Diagnosis of Pain: A Mini Review

Hascalovici,

Babb,

Norwood

2023

Semin Musculoskelet Radiol

View full text Add to dashboard Cite

The diagnosis and understanding of pain is challenging in clinical practice. Assessing pain relies heavily on self-reporting by patients, rendering it inherently subjective. Traditional clinical imaging methods such as computed tomography and magnetic resonance imaging can only detect anatomical abnormalities, offering limited sensitivity and specificity in identifying pain-causing conditions. Radiotracers play a vital role in molecular imaging that aims to identify abnormal biological processes at the cellular level, even in apparently normal anatomical structures. Therefore, molecular imaging is an important area of research as a prospective diagnostic modality for pain-causing pathophysiology. We present a mini review of the current knowledge base regarding radiotracers for identification of pain in vivo. We also describe radiocaine, a novel positron emission tomography imaging agent for sodium channels that has shown great potential for identifying/labeling pain-producing nerves and producing an objectively measurable pain intensity signal.

show abstract

“…Once duplicates were removed and 1375 titles and abstracts were screened, 52 articles were deemed suitable for full-text review. Fourteen studies [17][18][19][28][29][30][31][32][33][34][35][36][37][38] finally met the eligibility criteria. including 12 randomised trials (3 with a parallel-group design [28][29][30] and 9 with a crossover design [17][18][19][31][32][33][34][35]38 ) and 2 non-randomised trials (1 mixed quantitative-qualitative 36 and 1 qualitative 37 ).…”

Section: Literature Searchmentioning

confidence: 99%

“…Most studies were conducted in Western countries, including the US (N = 6 17,18,31,33,34,36 ), UK (N = 2 19,37 ) and Netherlands (N = 2 35,38 ). Only four studies [28][29][30]32 originated from non-western countries and one of these recruited Chinese-speaking people from China and Canada.…”

Section: Description Of Study Design and Participantsmentioning

confidence: 99%

Clinical efficacy and patients’ perception of virtual reality during wound care in adults: A systematic review with meta‐analysis of randomised clinical trials

Mazaheri,

Crooijmans,

Vereen

et al. 2023

Wound Repair Regeneration

View full text Add to dashboard Cite

This study was aimed to review Virtual Reality's (VR) impact on pain, anxiety, opioid usage, physiological and behavioural responses, and patients’ experience during wound care (WC) in adults. We searched multiple databases (Embase, Medline ALL, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, CINAHL, Scopus and Google Scholar) from inception until January 27th, 2023. Included studies compared VR alone or as an adjunct to standard WC with standard WC or other distraction methods, in adults with burn or non‐burn‐related wounds. The risk of bias was assessed using the revised Cochrane risk‐of‐bias tool for randomised parallel‐group and crossover trials. The review followed PRISMA guidelines for reporting. Fourteen studies were eligible for inclusion. The meta‐analysis was limited to studies comprising solely of adult participants. VR reduced pain intensity compared to standard WC in all study designs. Despite not being included in the meta‐analysis due to reasons such as mixed population or lack of sufficient statistical data, other studies showed significant pain reduction using VR. Additionally, VR improved patients' experience of WC. No clear effect was found on other outcomes including anxiety, opioid usage and physiological and behavioural responses. VR shows promise in reducing acute pain and enhancing patients' experience of WC. The observed variations in the effects of VR at group and individual levels indicate the need for a personalised treatment plan by selecting the right VR for the right patient given at the right time.

show abstract

The Role of the Cerebellum in Pain Perception: A Brain SPECT Perfusion Study in Patients with Burn Injuries

Cited by 8 publications

References 25 publications

Diffusion tensor imaging reveals sex differences in pain sensitivity of rats

Diffusion tensor imaging reveals sex differences in pain sensitivity of rats

Radiotracers in the Diagnosis of Pain: A Mini Review

Clinical efficacy and patients’ perception of virtual reality during wound care in adults: A systematic review with meta‐analysis of randomised clinical trials

Contact Info

Product

Resources

About