The Role of the Circadian System in Attention Deficit Hyperactivity Disorder

Abstract

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Interaction of Diamine Oxidase with Psychostimulant Drugs for ADHD Management

“…The reason is that the presence of DAO in the gut during the day is required when histamine-rich food is consumed, in order to degrade histamine and prevent its absorption. However, the implications of this rhythmicity for stablishing the posology of DAO supplementation, especially in ADHD patients characterized by disruption of circadian rhythm [45], provides growing evidence that disruptions of the circadian rhythm may play a role in the development and progression of ADHD [46], disturbing the sleep-wake cycle by delaying sleep onset, shortening sleep duration, and increasing daytime sleepiness. Stimulant medications used to treat ADHD, such as methylphenidate and amphetamines, have a short half-life, and are administered with delayed-release formulas once in the morning or, if necessary, twice a day doses, in the morning and midday [3,47].…”