Prescribing for children and young people highlights many complex issues that may not be relevant in other fields of non-medical prescribing. Ongoing changes to legislation pose challenges, requiring paediatric non-medical prescribers to be vigilant in their daily prescribing practice. This article aims to address pertinent challenges and barriers frequently seen in prescribing for children and young people, including not only organisational and human factors, but also legal issues, controversial prescribing, education, the impact of the recent Covid-19 pandemic, and how that has influenced the rise in childhood obesity, in itself an important element.