The Role of the Disorders of Cell Matrix Interactions in the Pathogenesis of Pulmonary Fibrosis Progression

Khorinko, Andrey V.; Амарантов, Д. Г.; Косарева, П. В.

doi:10.18499/2225-7357-2016-5-3-84-89

Cited by 6 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3. вычисляется СБ, и при значении СБ 6,97 и более следует прогнозировать высокий риск прогрессирова- Прогнозирование течения хронических бронхолёгочных заболеваний у детей, в частности пневмофиброза, является актуальной задачей современной педиатрии и пульмонологи, для решения которой могут быть использованы не только клинические, но и лабораторные, например, молекулярно-генетические, критерии [10,11]. Перспективные исследования показывают, что необратимые изменения в функции легких начинаются еще в младенчестве, приводящие в последствии к нарушению функции легких и клиническим заболеваниям во взрослом возрасте, что ухудшает качество жизни пациентов и требует значительных финансовых затрат для достижения контроля над течением болезни [12][13][14].…”

Section: материалы и методы исследованияunclassified

Prognosis of the risk progression of post-inflammatory pneumofibrosis in children with chronic nonspecific lung diseases

Knizhnikova,

Evseeva,

Pichuginа

et al. 2023

Bûlletenʹ fiziologii i patologii dyhaniâ

View full text Add to dashboard Cite

Introduction. Pneumofibrosis (PF) is a morphological outcome of acute and chronic lung diseases, the progression of which leads to organ deficiency.Aim. Development of a prognostic algorithm for assessing the risk of progression of post-inflammatory PF in children with chronic nonspecific lung diseases (CNSLD).Materials and methods. The examination of 52 children with CNSLD with focal post-inflammatory PF was conducted, of which 26 children with progressive PF and 26 children with non-progressive PF. The children were selected according to the “case-control” scheme. The patients had a dynamic clinical and laboratory examination with multispiral computed tomography of the lungs. Determination of the “zero” genotypes of the detoxification genes GSTM1, GSTT1 was carried out by means of polymerase chain reaction. The odds ratio indicator was used to assess the relative risk.Results. Based on the analysis of medico-social, clinical characteristics and genetic polymorphism, an individual prognostic algorithm for the risk of progression of post-inflammatory PF in children with CNSLD was developed. The algorithm includes the calculation of the total score (TS) of 7 medical and social indicators (living in an urban area; the presence of passive smoking; the duration of a pulmonological history of 4-9 years; the presence of congenital lung malformation; the number of acute respiratory infections (ARI) 4 or more times/year; the duration of ARI 11 days or more; taking antibiotics for more than 3 once/year) and the presence of deletions in the detoxification genes GSTM1 and GSTT1. With a value of TS 6.97 or more, a high risk of progression of PF is predicted, with TS 3.47-6.96 points, a moderate risk of progression of PF is diagnosed, with TS 3.46 or less points, a minimal risk of progression of PF.Conclusion. The proposed algorithm allows predicting the risk of progression of post-inflammatory PF in children with CNSLD at the stage of early diagnosis and will prevent the spread of the process in the lungs with the help of preventive measures and preventive therapy, which will increase the duration and improve the quality of life of the patient.

show abstract

Section: материалы и методы исследованияunclassified

Prognosis of the risk progression of post-inflammatory pneumofibrosis in children with chronic nonspecific lung diseases

Knizhnikova,

Evseeva,

Pichuginа

et al. 2023

Bûlletenʹ fiziologii i patologii dyhaniâ

View full text Add to dashboard Cite

show abstract

“…Хронические заболевания легких при длительном течении постепенно приводят к вовлечению в патологический процесс паренхимы легких, что безусловно отражается на спирографических показателях с появлением признаков рестрикции на фоне ранее имеющихся обструктивных признаков [20]. Известно, что в измененных фиброзных очагах легкого воспаление может не прекращаться, являясь центром пораженного участка и долгое время оставаясь основным преморбидным фоном рецидивирующей бронхолегочной патологии и, в определенных пределах, выраженность воспаления определяет степень ремоделирования и фиброза [21,22].…”

Section: результаты исследования и их обсуждениеunclassified

Indicators of lung function in children with chronic nonspecific lung diseases with pulmonary fibrosis

Knizhnikova

Евсеева

Polubartseva

et al. 2022

Bûlletenʹ fiziologii i patologii dyhaniâ

View full text Add to dashboard Cite

Introduction. The pathogenesis of most chronic nonspecific lung diseases (CNSLD) in children is based on a long-term inflammatory process, often leading to the formation of pulmonary fibrosis in the structurally altered tissue, which requires dynamic monitoring of patients, including the study of lung function.Aim. To assess the indicators of the lung function in children with chronic bronchopulmonary pathology accompanied by pulmonary fibrosis.Materials and methods. 84 children with CNSLD were examined. The main group consisted of 45 children with CNSLD with pulmonary fibrosis (bronchopulmonary dysplasia, congenital malformations of the lungs, chronic bronchitis, and post pneumonia fibrosis). The comparison group consisted of 39 children with CNSLD without pulmonary fibrosis. The average age of children in the study groups was 9,3±0,48 years. The patients underwent multispiral computed tomography of the lungs with a virtual bronchoscopy program and intravenous bolus contrast enhancement. Evaluation of lung function was carried out by spirometry.Results. In patients in remission, the average values of the ventilation capacity of the lungs in both groups were within the predicted values. However, in patients with fibrotic changes, pulmonary dysfunction was detected 2 times more often than in children with CNSLD without pulmonary fibrosis (35.5% and 15.4%, respectively, p<0.05). Restrictive ventilation disorders were diagnosed only in the group of patients with pulmonary fibrosis. In children with pulmonary fibrosis, the risk of reduced ventilation capacity is significantly higher than in children with CNSLD without pulmonary fibrosis (OR=3.04, 95% CI 1.049–8.78).Conclusion. The data obtained can serve as a prerequisite for further development of predicting the nature of the course of the disease, identifying “risk groups” for the development of fibrotic changes for a personalized approach to the treatment and follow-up of patients with CNSLD.

show abstract

“…Така знахідка на-штовхує на думку про те, що у щурів лінії WAG епітелій канальців, можливо, має в тому числі й мезенхімальне походження, який під час розвитку набуває епітеліального фенотипу. Перетворення (трансформація) епітеліальних клітин у мезенхімальні і, на-впаки, мезенхімальних клітин в епітеліальні є одним із основних процесів, характерних для нормальної регенерації тканин та ембріо-нального розвитку [19].…”

Section: результати та їх обговоренняunclassified

Immunohistochemical Characteristics of Some Mesenchymal and Epithelial Markers Expression in the Kidneys, Ureters and Bladder of Wag Rats Descendants That Developed Under Physiological Conditions

Sorokina¹,

Myroshnychenko²,

Kapustnyk³

et al. 2018

Fiziol Zh

View full text Add to dashboard Cite

Визначено особливості експресії мезенхімальних (віментину, гладеньком'язового актину, десміну) та епітеліальних (цитокератинів 18 та 19) WAG; плід; новонароджений; нирка; сечовід; сечовий міхур; віментин; гладеньком'язовий актин; десмін; цитокератини 18 та 19.

show abstract

The Role of the Disorders of Cell Matrix Interactions in the Pathogenesis of Pulmonary Fibrosis Progression

Cited by 6 publications

References 0 publications

Prognosis of the risk progression of post-inflammatory pneumofibrosis in children with chronic nonspecific lung diseases

Prognosis of the risk progression of post-inflammatory pneumofibrosis in children with chronic nonspecific lung diseases

Indicators of lung function in children with chronic nonspecific lung diseases with pulmonary fibrosis

Immunohistochemical Characteristics of Some Mesenchymal and Epithelial Markers Expression in the Kidneys, Ureters and Bladder of Wag Rats Descendants That Developed Under Physiological Conditions

Contact Info

Product

Resources

About