The Role of the Dorsal Hippocampal Serotonergic and Cholinergic Systems in the Modulation of Anxiety

File, Sandra E.; Kenny, Paul J.; Cheeta, Survjit

doi:10.1016/s0091-3057(00)00198-2

Cited by 226 publications

(119 citation statements)

References 60 publications

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“…We do not really know the reason for this, but it may relate to the indirect effects of nicotine, perhaps by acting at presynaptic receptors to enhance neurotransmitter release. The neurochemical mechanisms have not been explored in the plus-maze, but in the social interaction test the evidence suggests that nicotine exerts its anxiogenic effect by increasing 5-HT release (see File et al, 2000 for a review). In the hippocampus, nicotine increases 5-HT release and has an anxiogenic effect only at a high dose (Kenny et al, 2000a, b).…”

Section: Discussionmentioning

confidence: 99%

Dietary Restriction and Nicotine can Reduce Anxiety in Female Rats

Genn

Tucci

Edwards

et al. 2003

Neuropsychopharmacol

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Anxiety may play a role in the initiation of smoking and there is evidence to suggest that sex and age may predetermine responses to nicotine. At present, the greatest increase in smoking is in women and it is often accompanied by dieting. The purpose of the present study was to investigate how the impact of dietary restriction might modify the effects of nicotine in female adult and adolescent rats. The effects of nicotine in the elevated plus-maze test of anxiety were compared in free-feeding animals and those subjected to dietary restriction that reduced body weight to 85% of free-feeding weight. In nondeprived adult females, nicotine (0.05-0.5 mg/kg, s.c.) reduced the percentage of time spent on the open arms, indicating anxiogenic effects. However, the effects of nicotine were dramatically changed in food-restricted adult females and 0.05 mg/kg had a striking anxiolytic effect. No significant effects of nicotine were found in the adolescent female rats, suggesting a role of circulating sex hormones in modulating nicotine's effects on anxiety. However, in the adolescent females, dietary restriction significantly increased the percentages of time spent and entries onto the open arms, without changing closed arm entries, indicating an anxiolytic effect. These results raise the important possibility that, in prepubertal girls, dietary restriction may have anxiolytic effects and this might contribute to the onset of anorexia. Circulating female hormones reduce this effect, but in adult females the combination of dietary restriction and nicotine may have important anxiolytic effects that impact on the initiation of regular smoking.

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Section: Discussionmentioning

confidence: 99%

Dietary Restriction and Nicotine can Reduce Anxiety in Female Rats

Genn

Tucci

Edwards

et al. 2003

Neuropsychopharmacol

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“…Nevertheless, it seems unlikely that the basomedial amygdala and the dorsal hippocampus considerably participate in the ADPbSinduced anxiolytic-like response because the basomedial amygdala is mainly involved in mediating feeding and social behavior as well as emotion-related learning (Petrovich et al, 1996). The dorsal hippocampus does not seem to play an important role in controlling the behavior during the first exposure to the plus-maze system (Treit and Menard 1997;File et al, 1998File et al, , 2000.…”

Section: Discussionmentioning

confidence: 99%

Stimulation of P2Y1 Receptors Causes Anxiolytic-like Effects in the Rat Elevated Plus-maze: Implications for the Involvement of P2Y1 Receptor-Mediated Nitric Oxide Production

Kittner

Franke

Fischer

et al. 2002

Neuropsychopharmacol

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(ADPbS), the P2X 1,3 receptor agonist a,b-methylene ATP (a,bmeATP), the unspecific P2 receptor antagonist pyridoxalphosphate-6-azopheny l-2 0 ,4 0 -disulfonic acid (PPADS), and the specific P2Y 1 receptor antagonist N 6 -methyl-2 0 -deoxyadenosine-3 0 ,5 0 -bisphosphate (MRS 2179) on the elevated plus-maze behavior of the rat were investigated. All tested compounds were given intracerebroventricularly (0.5 ml). ADPbS (50 and 500 fmol) produced an anxiolytic-like behavioral profile reflected by an increase of the open arm exploration. The anxiolytic-like effects were antagonized by pretreatment with PPADS (5 pmol) or MRS 2179 (5 pmol). Both compounds caused anxiogenic-like effects when given alone. Furthermore, the anxiolytic-like effects of ADPbS could be antagonized by pretreatment with the nitric oxide synthase (NOS) inhibitor N w -nitro-L-arginine methyl ester (L-NAME). In addition, the anxiogenic-like effects of PPADS were reversed by the pretreatment with L-arginine (500 pmol), which is the natural substrate for NOS, but not by D-arginine (500 pmol), which is not. Immunofluorescence staining revealed the presence of P2Y 1 receptors on neurons in different brain regions such as hypothalamus, amygdala, hippocampus and the periaqueductal gray. Furthermore, the colocalization of P2Y 1 receptors and neuronal NOS (nNOS) on some neurons in these regions could be demonstrated. The highest density of P2Y 1 -and nNOS-immunoreactivity was detected in the dorsomedial hypothalamic nucleus. Taken together, the present results suggest that P2Y 1 receptors are involved in the modulation of anxiety in the rat. The anxiolytic-like effects after stimulation of P2Y 1 receptors seem to be in close connection with the related nitric oxide production.

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“…Although the molecular organization for the receptor transduction seems to be identical in all of the areas where 5-HT 1A receptors are expressed, some differences in both functional and regulatory properties have been reported from area to area (131). Studies in animals and humans implicate the 5-HT 1A receptor in anxiety (132)(133)(134) and depression and/ or suicide (55,135,136).…”

Section: -Ht 1a Receptormentioning

confidence: 99%

“…5-HT 1A receptor activity has been reported to play a role in anxiety (133). For example, some, but not all studies, show that 5-HT 1A knockout mice have increased anxiety (140).…”

Section: -Ht 1a Receptormentioning

confidence: 99%