The Role of the Endothelin System in the Vascular Dysregulation Involved in Retinitis Pigmentosa

Sorrentino, Francesco Saverio; Bonifazzi, C.; Perri, Paolo

doi:10.1155/2015/405234

Cited by 13 publications

(10 citation statements)

References 65 publications

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“…OBF in RP patients is reduced, obviously secondary to the degeneration of the retina. However, an additional primary component of OBF reduction is likely [18,19] as OBF reduction precede a major degeneration [6,10,13], and blood flow is reduced also in the retroocular vessels [6] and even in cutaneous capillaries [6] and ET in the circulating blood is increased. What could be the cause of this primary component?…”

Section: Increased Prevalence Of Flammer Syndrome In Patients With Rementioning

confidence: 99%

Increased Prevalence of Flammer Syndrome in Patients with Retinitis Pigmentosa

Konieczka

Koch

Schoetzau

et al. 2016

Klin Monatsbl Augenheilkd

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Section: Increased Prevalence Of Flammer Syndrome In Patients With Rementioning

confidence: 99%

Increased Prevalence of Flammer Syndrome in Patients with Retinitis Pigmentosa

Konieczka

Koch

Schoetzau

et al. 2016

Klin Monatsbl Augenheilkd

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“…It has been shown that many pathogenic stimuli such as diabetes and oxidative stress induce vascular dysfunction, leading to atherosclerosis, ischemia, inflammation and thrombosis may alter the regulation of retinal and choroidal blood flow [10]. According to recent studies, alteration in SFCT might be related with microvascular dysregulation entities [11][12][13][14]. OCT is a noninvasive and rapid method for multi-modal imaging the retina and choroid.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Angiographic Coronary Slow Flow Phenomenon and Subfoveal Choroidal Thickness: What is The Effect of Atorvastatin Therapy?

Kanar¹,

Kanar²

2018

Eur J Exp Bio

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Objective: Although the pathophysiological mechanisms underlying coronary slow flow (CSF) phenomenon still remains uncertain, the microvascular dysfunction has been first implicated. The CSF phenomenon may not only affect the coronary arteries but it may also be a part of vascular problem that affect other arteries. The aim of the present study is to evaluate the relationship between CSF phenomenon and subfoveal choroidal thickness (SFCT) and to investigate the effect of short-term atorvastatin therapy on SFCT in patients with CSF. Methods:The study population consisted of 48 patients with CSF and 41 healthy control participants. Coronary flow patterns of the patients were determined by thrombolysis in myocardial infarction (TIMI) frame count method. Spectral-domain optical coherence tomography (SD-OCT) measurements of SFCT and lipid parameters were obtained before and after 2 weeks of daily single dose of 80 mg atorvastatin therapy. Results:We found that patients with CSF had thinner SFCT compared with control group. There was a significant negative correlation between mean TIMI frame count and baseline SFCT (r=-0.69, p=0.001). ROC curve analysis revealed that SFCT <259 m predicted CSF with a 85% sensitivity and 88% specificity. The SFCT significantly increased after the short-term atorvastatin therapy. Conclusion:There was a close negative correlation between CSF phenomenon and SFCT. Endothelial dysfunction (ED) and the resultant microvascular dysfunction might be operative on both coronary and ocular choriocapillary arteries in patients with CSF. Increase of SFCT after the short-term atorvastatin therapy might be an indicator of microvascular dysfunction improvement in patients with CSF.

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“…For retinal vascular changes, studies suggest that a reduced retinal blood flow could be a response to a decreased metabolism after ganglion cell death and a loss of photoreceptors due to reactive vessel constriction [21-23]. This hypothesis has been supported by the finding of an increase in endothelin-1, a powerful endogenous vasoconstrictor factor in the eyes of retinitis pigmentosa patients [22, 24, 25]. In our study, the postvitelliform group of BVMD revealed a reduction in superficial vessel density compared to the vitelliform group, although the difference did not reach a significant level, possibly due to the limited sample size.…”

Section: Discussionmentioning

confidence: 99%

Findings of Optical Coherence Tomography Angiography in Best Vitelliform Macular Dystrophy

Wang

You

et al. 2018

Ophthalmic Res

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Purpose: To evaluate the vascular anatomy of eyes with Best vitelliform macular dystrophy (BVMD) using optical coherence tomography angiography (OCTA). Methods: This retrospective case-control study enrolled 11 consecutive BVMD patients and 13 age-matched healthy participants. Both eyes of each participant were imaged using a macular OCTA scan (3 × 3 mm) by 70-kHz 840-nm spectral-domain OCT. The flow signal was calculated using the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm. Results: Qualitative analysis showed uneven hypo- and hyperintense signal changes at the choriocapillary level in OCTA images of BVMD patients. Quantitative analysis showed significant reductions in the flow density of the superficial vascular layer (whole: 49.2% vs. 53.9%, p < 0.001) and the choriocapillary flow area (5.1 vs. 5.5 mm², p = 0.02) in BVMD patients compared to controls. The choriocapillary flow area in the postvitelliform group was reduced compared to that of the vitelliform group. There was a statistically significant association between choriocapillary flow area and superficial vascular flow density (p = 0.045), choriocapillary flow area and foveal avascular zone area (p = 0.03). Conclusions: Vascular changes in BVMD were apparent in the choriocapillary layer. The changes became more striking in late stages of the disease. OCTA provides useful quantitative measurements for staging and monitoring the progression of BVMD.

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The Role of the Endothelin System in the Vascular Dysregulation Involved in Retinitis Pigmentosa

Cited by 13 publications

References 65 publications

Increased Prevalence of Flammer Syndrome in Patients with Retinitis Pigmentosa

Increased Prevalence of Flammer Syndrome in Patients with Retinitis Pigmentosa

Relationship Between Angiographic Coronary Slow Flow Phenomenon and Subfoveal Choroidal Thickness: What is The Effect of Atorvastatin Therapy?

Findings of Optical Coherence Tomography Angiography in Best Vitelliform Macular Dystrophy

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