The role of the fornix/fimbria and some related subcortical structures in place learning and memory

Sutherland, RJ; Rodríguez, Alberto J.

doi:10.1016/s0166-4328(89)80059-2

Cited by 357 publications

(297 citation statements)

References 37 publications

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“…Some might argue that the lack of “true” spatial proficiency in the water maze is a flaw or weakness of the study; however, given the focus on the emergence of spatial behavior, and that well-learned escape responses are dependent on other brain regions 21, 22 that contribute/correlate with movement parameters 19 , it seems reasonable to expect less performance-wise using the escape latency measure than what is typically observed in most studies of this type.…”

Section: Specific Considerationsmentioning

confidence: 99%

“…Only later studies showed that direct neurotoxin lesions of the hippocampus produced severe impairments 27, 28 . Sutherland and Rodriguez 22 showed that only complete transaction of the fornix/fimbria abolished both acquisition and retention of navigation to a hidden platform and detailed the effects of lesions to structures receiving input from the hippocampus via the fornix/fimbria, including severe impairments of postoperative acquisition produced by bilateral damage to the medial nucleus accumbens or bilateral damage to the anterior thalamic area with little effect on retention of preoperatively acquired place navigation. Also, damage to the medial septum or mammillary complex produced modest impairments evident only in postoperative acquisition.…”

Section: Neural Substrates Of Cognition and Spatial Performancementioning

confidence: 99%

“…Given the fact that fornix-lesioned rats may use compensatory strategies during escape acquisition 21 , and that a network of brain structures may contribute to spatial behavior 19, 22, 29 , it is possible that individual differences may emerge during development. Individual differences in adult rats during place navigation and following a latent learning test in a novel environment suggested differential influence of the stimulus control of spatial behavior, with entrance into a room representing a polarizing cue for some individuals 4 .…”

Section: Individual Differences In Spatial Behavior As a Function Of mentioning

confidence: 99%

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Hippocampal development and the dissociation of cognitive-spatial mapping from motor performance

2015

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The publication of a recent article in F1000Research has led to discussion of, and correspondence on a broader issue that has a long history in the fields of neuroscience and psychology. Namely, is it possible to separate the cognitive components of performance, in this case spatial behavior, from the motoric demands of a task? Early psychological experiments attempted such a dissociation by studying a form of spatial maze learning where initially rats were allowed to explore a complex maze, termed “latent learning,” before reinforcement was introduced. Those rats afforded the latent learning experience solved the task faster than those that were not, implying that cognitive map learning during exploration aided in the performance of the task once a motivational component was introduced. This form of latent learning was interpreted as successfully demonstrating that an exploratory cognitive map component was acquired irrespective of performing a learned spatial response under deprivation/motivational conditions. The neural substrate for cognitive learning was hypothesized to depend on place cells within the hippocampus. Subsequent behavioral studies attempted to directly eliminate the motor component of spatial learning by allowing rats to passively view the distal environment before performing any motor response using a task that is widely considered to be hippocampal-dependent. Latent learning in the water maze, using a passive placement procedure has met with mixed results. One constraint on viewing cues before performing a learned swimming response to a hidden goal has been the act of dynamically viewing distal cues while moving through a part of the environment where an optimal learned spatial escape response would be observed. We briefly review these past findings obtained with adult animals to the recent efforts of establishing a “behavioral topology” separating cognitive-spatial learning from tasks differing in motoric demands in an attempt to define when cognitive-spatial behavior emerges during development.

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Section: Specific Considerationsmentioning

confidence: 99%

Section: Neural Substrates Of Cognition and Spatial Performancementioning

confidence: 99%

Section: Individual Differences In Spatial Behavior As a Function Of mentioning

confidence: 99%

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Hippocampal development and the dissociation of cognitive-spatial mapping from motor performance

2015

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“…It is notable that impoverished housing is often used inadvertently in experiments which use brain lesions or canulae as a consequence of the surgical procedure, and which investigate behaviour (e.g. [16,25,27,29]). Since it is generally accepted that post-operative housing in enriched environments can affect behavioural deficits after cortical and hippocampal lesions [3,9], the present study concerned itself with the possible effects of postoperative impoverishment after a fimbria lesion.…”

Section: Introductionmentioning

confidence: 99%

“…Since it is generally accepted that post-operative housing in enriched environments can affect behavioural deficits after cortical and hippocampal lesions [3,9], the present study concerned itself with the possible effects of postoperative impoverishment after a fimbria lesion. Lesions to the Fimbria, as well as slightly larger lesions to the FimbriaFornix disrupt spatial learning in several tasks [2,21,22,25,27] (note: in some of these studies rats were housed individually), and this effect is still present after 7 months [33]. In the present study, rats with a Fimbria lesion were housed immediately after surgery in impoverished conditions for a short period (2 weeks) in experiment I, and subjected to long-term impoverishment (7 months) in experiment II.…”

Section: Introductionmentioning

confidence: 99%

Long-term impoverished housing effects on morris maze performance after a fimbria lesion

Rijzingen

Doremalen

Gispen

et al. 1996

Behavioural Brain Research

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Male Wistar rats received bilateral Fimbria lesions and were postoperatively housed in either standard social conditions or in impoverished conditions (one rat per cage) for 2 weeks in experiment I, and for 7 months in experiment II. The effects of lesion and housing conditions wer,~ investigated in the Morris maze spatial orientation task. Fimbria lesions increased the latency to reach the platform during acquisition in both experiments, which indicates that functional recovery of the Morris maze impairment does not occur in 7 months time. Post-operative impoverishment for 2 weeks or for 7 months reduced the lesion induced deficit in Morris maze acquisition, while it had a more general effect in the trial without platform. Interestingly, the impoverishment effects were not more severe after 7 months, but even less easily detected. These findings are interpreted as if impoverishment affects the reactiveness of a~imals to external stimuli, which may help the animal to compensate for the lesion-induced-deficit in Morris maze learning.

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The nucleus accumbens and learning and memory

Setlow

1997

J. Neurosci. Res.

107

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Recent research on the nucleus accumbens (NA) indicates that this brain region is involved in learning and memory processes in a way that is separable from its other well-known roles in behavior, such as motivation, reward, and locomotor activity. These findings have suggested that 1) the NA may be involved in declarative, or hippocampal formation-dependent learning and memory, and not in several other non-declarative forms of learning and memory, and 2) the NA may be selectively involved in certain stages of learning and memory. These characteristics suggest that the NA may be part of a larger striatal system which subserves acquisition and consolidation, but is not a site of long-term storage, of different forms of learning and memory.

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The role of the fornix/fimbria and some related subcortical structures in place learning and memory

Cited by 357 publications

References 37 publications

Hippocampal development and the dissociation of cognitive-spatial mapping from motor performance

Hippocampal development and the dissociation of cognitive-spatial mapping from motor performance

Long-term impoverished housing effects on morris maze performance after a fimbria lesion

The nucleus accumbens and learning and memory

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