The role of the glucagon‐FGF21 axis in improving beta cell function during glucose intolerance and SGLT2 inhibition
Maria Moreno‐Lopez,
Isaline Louvet,
Nathalie Delalleau
et al.
Abstract:ObjectiveAlthough primarily secreted by the liver, Fibroblast Growth Factor 21 (FGF21) is also expressed in the pancreas, where its function remains unclear. This study aims to elucidate the role of the glucagon‐FGF21 interaction in the metabolic benefits of SGLT2 inhibition (SGLT2i) and hypothesizes it is key to enhancing glucose and lipid metabolism in individuals with glucose intolerance or type 2 diabetes (T2D).MethodsFGF21, FGF1R, and β‐klotho expression in human pancreas was analysed by RNAscope, qPCR an… Show more
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