The role of the gut microbiome in weight-gain in schizophrenia patients treated with atypical antipsychotics: Evidence based on altered composition and function in a cross-sectional study

Fang, Xinyu; Gao, Chunying; Wu, Weifeng; Hu, Xiuxiu; Shao, Miaomiao; Zhou, Chou; Cai, Renliang; Fang, Jin; Li, Yi; Xu, Yue; Zhang, Xiangrong

doi:10.1016/j.psychres.2023.115463

Cited by 4 publications

(2 citation statements)

References 48 publications

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“…The possibility that these atypical antipsychotic drugs may influence the molecular determinants of synaptic plasticity and brain activity while exerting their therapeutic effects also affects the central response to the side effects of these drugs ( Ibi et al, 2017 ; de Bartolomeis et al, 2022 ). Current understanding of the adverse effects induced by olanzapine indicates a complex interplay among brain activity, particularly involving the hypothalamic area and its interaction with other brain regions, though these mechanisms necessitate further clarification ( Martins et al, 2010 ; Stanley et al, 2010 ; Chen et al, 2022 ; Huang et al, 2022 ; Fang et al, 2023 ; Meng et al, 2023 ). It is highly worthwhile to explore the changes in central network functional connectivity corresponding to the induction of peripheral obesity and metabolic side effects by olanzapine.…”

Section: Introductionmentioning

confidence: 99%

Characterizing defective lipid metabolism in the lateral septum of mice treated with olanzapine: implications for its side effects

Huang,

Sun,

Luo

et al. 2024

Front. Pharmacol.

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Schizophrenia significantly impacts cognitive and behavioral functions and is primarily treated with second-generation antipsychotics (SGAs) such as olanzapine. Despite their efficacy, these drugs are linked to serious metabolic side effects which can diminish patient compliance, worsen psychiatric symptoms and increase cardiovascular disease risk. This study explores the hypothesis that SGAs affect the molecular determinants of synaptic plasticity and brain activity, particularly focusing on the lateral septum (LS) and its interactions within hypothalamic circuits that regulate feeding and energy expenditure. Utilizing functional ultrasound imaging, RNA sequencing, and weighted gene co-expression network analysis, we identified significant alterations in the functional connection between the hypothalamus and LS, along with changes in gene expression in the LS of mice following prolonged olanzapine exposure. Our analysis revealed a module closely linked to increases in body weight and adiposity, featuring genes primarily involved in lipid metabolism pathways, notably Apoa1, Apoc3, and Apoh. These findings suggest that olanzapine may influence body weight and adiposity through its impact on lipid metabolism-related genes in the LS. Therefore, the neural circuits connecting the LS and LH, along with the accompanying alterations in lipid metabolism, are likely crucial factors contributing to the weight gain and metabolic side effects associated with olanzapine treatment.

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Section: Introductionmentioning

confidence: 99%

Characterizing defective lipid metabolism in the lateral septum of mice treated with olanzapine: implications for its side effects

Huang,

Sun,

Luo

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…The possibility that these atypical antipsychotic drugs may influence the molecular determinants of synaptic plasticity and brain activity while exerting their therapeutic effects also affects the central response to the side effects of these drugs (Ibi et al, 2017;de Bartolomeis et al, 2022). Current understanding of the adverse effects induced by olanzapine indicates a complex interplay among brain activity, particularly involving the hypothalamic area and its interaction with other brain regions, though these mechanisms necessitate further clarification Stanley et al, 2010;Chen et al, 2022;Huang et al, 2022;Fang et al, 2023;Meng et al, 2023). It is highly worthwhile to explore the changes in central network functional connectivity corresponding to the induction of peripheral obesity and metabolic side effects by olanzapine.…”

Section: Introductionmentioning

confidence: 99%

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Causal effect of air pollution on the risk of brain health and potential mediation by gut microbiota

Zhou,

Guo,

Ling

et al. 2024

Ecotoxicology and Environmental Safety

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The role of the gut microbiome in weight-gain in schizophrenia patients treated with atypical antipsychotics: Evidence based on altered composition and function in a cross-sectional study

Cited by 4 publications

References 48 publications

Characterizing defective lipid metabolism in the lateral septum of mice treated with olanzapine: implications for its side effects

Characterizing defective lipid metabolism in the lateral septum of mice treated with olanzapine: implications for its side effects

Table1.XLSX

Causal effect of air pollution on the risk of brain health and potential mediation by gut microbiota

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