The role of the gut microbiome in the intergenerational transmission of the obesity phenotype: A narrative review

Tang, Mabel; Marroquin, Elisa Morales

doi:10.3389/fmed.2022.1057424

Cited by 4 publications

(2 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Дети, рожденные путем операции КС, лишены контакта с микробиотой влагалища и фекалий матери, в результате наблюдаются отклонения в формировании микробиоты, особенно в первые месяцы жизни [11,12] Гастроэнтерология поверхностный полисахарид Bacteroides fragilis распознается Toll-подобными рецепторами 2-го типа (TLR-2), что запускает синтез интерлейкина-10 и других цитокинов, которые влияют на баланс Th1/Th2 и способствуют иммунотолерантности [13]. У детей, рожденных путем КС, наблюдается более высокий риск развития инфекционных и неинфекционных заболеваний, таких как аллергия, диабет, целиакия и ожирение [14][15][16][17][18].…”

Section: Discussionunclassified

Intestinal microbiota features of children born by cesarean section and its correction

Dedikova,

Zakharova,

Kuchina

et al. 2024

Medicinskij sovet

View full text Add to dashboard Cite

Introduction. Studying the gut microbiota of C-section newborns and its correction is a topical problem at present.Aim. To study the process of gut microbiota formation in healthy C-section infants, and the option for its correction using a Lactobacillus reuteri strain DSM 17938 probiotic.Materials and methods. A total of 80 healthy newborns were included in the study. Of these, 59 completed the study: the treatment group consisted of 36 elective caesarean (EC)-section infants and the control group was made up of 23 vaginally delivered infants. Newborns of the treatment study group were randomized into subgroups, one of which received the L. reuteri strain DSM 17938 (L subgroup) probiotic, and the second one did not receive it (0 subgroup). During the entire period of the study, infants were exclusively breastfed. The gut microbiota was analysed with the 16S rRNA sequencing method, and the metabolic activity of the gut microbiota was additionally assessed using gas-liquid chromatography.Results and discussion. The metagenomic analysis showed that the taxonomic richness and biological diversity of the gut microbiota in L subgroup infants increased in time interval 3, which indicated the active effect of the strain on the infant microbiota by Exposure Day 30. The gas-liquid chromatography analysis showed more pronounced changes in short-chain fatty acids in infants of the L subgroup: they were more similar to the findings in the control group (vaginal delivery). Also, bowel problems and allergies occurred less frequently in infants of this subgroup and they less frequently suffered from respiratory diseases during the year. The study showed the association between the mode of delivery and changes in anthropometric measurements.Conclusion. The use of L. reuteri strain DSM 17938 probiotic had a significant effect on the formation of the microbiota by the 30th day of age. A daily long-term addition of a L. reuteri strain DSM 17938 probiotic can prevent early microbiota dysbiosis and have a protective effect in later age period.

show abstract

Section: Discussionunclassified

Intestinal microbiota features of children born by cesarean section and its correction

Dedikova,

Zakharova,

Kuchina

et al. 2024

Medicinskij sovet

View full text Add to dashboard Cite

show abstract

“…Not only that, research has also demonstrated that the formation of the gut microbiome and metabolic health in infants, which is influenced by the mother’s HFD-induced obesity as well as environmental exposures, may play a role in the transmission of obesity and metabolic disorders from one generation to the next [ 85 , 86 ]. Although the impact of paternal gut dysbiosis and metabolic dysfunction on future generations remains unclear, this study would benefit from exploring the transgenerational effects of combined BPA exposure and TFD on the gut microbiome or metabolic health of subsequent generations.…”

Section: Discussionmentioning

confidence: 99%

Distinct gut flora profile induced by postnatal trans-fat diet in gestationally bisphenol A-exposed rats

Zulkifli,

Mohd Nor,

Sheikh Abdul Kadir

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

There has been much evidence showing the repercussions of prenatal bisphenol A (BPA) exposure with a postnatal high fat-diet (HFD) on offspring’s health. However, the information on how the interaction between these two variables affects the gut microbiome is rather limited. Hence, we investigated the impact of a postnatal trans fat diet (TFD) on the gut microbiome of offspring exposed to BPA during the prenatal period in an animal model. Pregnant rats were divided into 5 mg/kg/day BPA, vehicle Tween80 (P80) or control (CTL) drinking water until delivery (N = 6 per group). Then, weaned male pups were further subdivided into three normal diet (ND) groups (CTLND, P80ND, and BPAND) and three TFD groups (CTLTFD, P80TFD, and BPATFD) (n = 6 per group). 180–250 g of faecal samples were collected on days 50 and 100 to assess the composition of the offspring’s intestinal flora using next-generation sequencing. The alpha diversity indices of TFD offspring with and without BPA were markedly lower than their ND counterparts (p<0.001–p<0.05). The beta diversity, hierarchical cluster and network analyses of the offspring’s microbiome demonstrated that the microbiome species of the TFD group with and without BPA were distinctly different compared to the ND group. Consistently, TFD and ND offspring pairings exhibited a higher number of significantly different species (p<0.0001–p<0.05) compared to those exposed to prenatal BPA exposure and different life stages comparisons, as shown by the multivariate parametric analysis DESeq2. Predictive functional profiling of the offspring’s intestinal flora demonstrated altered expressions of genes involved in metabolic pathways. In summary, the gut flora composition of the rat offspring may be influenced by postnatal diet instead of prenatal exposure to BPA. Our data indicate the possibility of perturbed metabolic functions and epigenetic modifications, in offspring that consumed TFD, which may theoretically lead to metabolic diseases in middle or late adulthood. Further investigation is necessary to fully understand these implications.

show abstract

Maternal obesity and placental function: impaired maternal–fetal axis

Louwen,

Kreis,

Ritter

et al. 2024

Arch Gynecol Obstet

View full text Add to dashboard Cite

The prevalence of maternal obesity rapidly increases, which represents a major public health concern worldwide. Maternal obesity is characteristic by metabolic dysfunction and chronic inflammation. It is associated with health problems in both mother and offspring. Increasing evidence indicates that the placenta is an axis connecting maternal obesity with poor outcomes in the offspring. In this brief review, we have summarized the current data regarding deregulated placental function in maternal obesity. The data show that maternal obesity induces numerous placental defects, including lipid and glucose metabolism, stress response, inflammation, immune regulation and epigenetics. These placental defects affect each other and result in a stressful intrauterine environment, which transduces and mediates the adverse effects of maternal obesity to the fetus. Further investigations are required to explore the exact molecular alterations in the placenta in maternal obesity, which may pave the way to develop specific interventions for preventing epigenetic and metabolic programming in the fetus.

show abstract

The role of the gut microbiome in the intergenerational transmission of the obesity phenotype: A narrative review

Cited by 4 publications

References 90 publications

Intestinal microbiota features of children born by cesarean section and its correction

Intestinal microbiota features of children born by cesarean section and its correction

Distinct gut flora profile induced by postnatal trans-fat diet in gestationally bisphenol A-exposed rats

Maternal obesity and placental function: impaired maternal–fetal axis

Contact Info

Product

Resources

About