The Role of the Hepatocyte Nuclear Factor Network in Glucose Homeostasis

Stoffel, Markus

doi:10.1007/978-1-4615-1669-9_15

Cited by 3 publications

(4 citation statements)

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“…Numerous studies have shown that the HNFs as well as other islet-enriched transcription factors fall into a regulatory network [54]. Identification of these transcription factors as diabetes susceptibility genes and MODY highlights their importance in the normal function of the endocrine pancreas.…”

Section: The Transcriptional Network Of the Pancreatic Isletmentioning

confidence: 99%

“…The highly conserved DNA-binding domain of the HNF-3 proteins is similar to that of linker histones H1 and H5. However, in contrast to linker histones that compact DNA chromatin and repress gene expression, HNF-3 proteins have been shown to decompact DNA from the nucleosome and are associated with transcriptionally active chromatin [54]. HNF-3β and HNF-1β regulate the expression of HNF-4α and HNF-1α [47,48,55].…”

Section: The Transcriptional Network Of the Pancreatic Isletmentioning

confidence: 99%

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Molecular etiologies of mody and other early-onset forms of diabetes

Shih

Stoffel

2002

Curr Diab Rep

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Maturity-onset diabetes of the young (MODY) are monogenic forms of type 2 diabetes that are characterized by an early disease onset, autosomal-dominant inheritance, and defects in insulin secretion. Genetic studies have identified mutations in at least eight genes associated with different forms of MODY. The majority of the MODY subtypes are caused by mutations in transcription factors that include hepatocyte nuclear factor (HNF)-4 alpha, HNF-1 alpha, PDX-1, HNF-1 beta, and NEURO-DI/BETA-2. In addition, genetic defects in the glucokinase gene, the glucose sensor of the pancreatic beta cells, and the insulin gene also lead to impaired glucose tolerance. Biochemical and genetic studies have demonstrated that the MODY genes are functionally related and form an integrated transcriptional network that is important for many metabolic pathways.

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Section: The Transcriptional Network Of the Pancreatic Isletmentioning

confidence: 99%

Section: The Transcriptional Network Of the Pancreatic Isletmentioning

confidence: 99%

Molecular etiologies of mody and other early-onset forms of diabetes

Shih

Stoffel

2002

Curr Diab Rep

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“…In addition, the hepatocyte nuclear factors (HNFs) are a family of transcription factors originally identified to act on liver-specific genes. 57 HNFs are important in endocrine cell development: During initial stages of pancreatic development, HNFs contribute to cell differentiation toward the endocrine lineage; in later stages, HNFs regulate the expression of PDX-1 and Beta2 that contribute to the final stages of A-cell differentiation, whereas HNF3> directly regulates >-cell development. Loss-of-function studies in mice and in vitro analyses suggest that HNF6 is a direct activator of Ngn3 transcription.…”

Section: Pancreasmentioning

confidence: 99%

“…58,59 Some HNFs control insulin gene transcription, glucose sensing by A-cells, and detoxification of endogenous and exogenous substances. 57 GATA transcription factors, of which 6 types (GATA1-6) have been identified, belong to the zinc finger family of proteins that regulate gene expression, development, and cell proliferation. GATA-4, GATA-5, and GATA-6 are expressed in various endodermal derivatives.…”

Section: Pancreasmentioning

confidence: 99%

Somatostatin and its Receptors in the Development of the Endocrine Pancreas

Ballian

Brunicardi²,

Wang³

2006

Pancreas

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The development of the endocrine pancreas is regulated by numerous transcription and growth factors. Somatostatin (SST) is present in many tissues and acts as a neurotransmitter and autocrine/paracrine/endocrine regulator in response to ions, nutrients, peptides, and hormones as well as neurotransmitters. In the pancreas, there is evidence that SST acts an inhibitory paracrine regulator of hormone secretion. Somatostatin receptors (SSTRs) are a family of 5 transmembrane G protein-coupled receptors, which are widely expressed in mammals including humans. SSTRs regulate multiple downstream signal transduction pathways that mediate inhibitory effects. These receptors also exhibit age- and tissue-specific expression patterns. Interactions of SST and SSTRs are not only important during normal pancreas development, but have also been implicated in many pancreatic diseases such as diabetes mellitus and pancreatic cancer. In this review article, we use evidence from recently published animal studies to present the critical roles of SST and SSTRs proteins in the development of the endocrine pancreas.

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Molecular Basis of Pancreas Development and Function

Habener¹,

Hussain²

2001

Endocrine Updates

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The Role of the Hepatocyte Nuclear Factor Network in Glucose Homeostasis

Cited by 3 publications

References 91 publications

Molecular etiologies of mody and other early-onset forms of diabetes

Molecular etiologies of mody and other early-onset forms of diabetes

Somatostatin and its Receptors in the Development of the Endocrine Pancreas

Molecular Basis of Pancreas Development and Function

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