The role of the histoblood ABO group in cancer

Rummel, Seth; Ellsworth, Rachel E.

doi:10.4155/fsoa-2015-0012

Cited by 49 publications

(64 citation statements)

References 81 publications

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“…A variety of biological traits have been linked to ABO histo‐blood group phenotypes. Reported associations include, among others, plasma lipid levels , susceptibility to H. pylori –associated disorders , cardiovascular disease , and cancer . Here, we have investigated ABO genetic variants and phenotypes in the context of pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

Associations between ABO blood groups and pancreatic ductal adenocarcinoma: influence on resection status and survival

et al. 2017

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Both serology‐based and genetic studies have reported an association between pancreatic cancer risk and ABO blood groups. We have investigated this relationship in a cohort of pancreatic cancer patients from Western Norway (n = 237) and two control materials (healthy blood donors, n = 379; unselected hospitalized patients, n = 6149). When comparing patient and blood donor ABO allele frequencies, we found only the A1 allele to be associated with significantly higher risk for pancreatic ductal adenocarcinoma (PDAC) (23.8% vs. 17.9%; OR = 1.43, P = 0.018). Analyzing phenotypes, blood group A was more frequent among PDAC cases than blood donors (50.8% vs. 40.6%; OR = 1.51, P = 0.021), an enrichment fully explained by the A1 subgroup. Blood group O frequency was lower in cases than in blood donors (33.8% vs. 42.7%; OR = 0.69, P = 0.039). This lower frequency was confirmed when cases were compared to hospitalized patients (33.8% vs. 42.9%; OR = 0.68, P = 0.012). Results for blood group B varied according to which control cohort was used for comparison. When patients were classified according to surgical treatment, the enrichment of blood group A was most prominent among unresected cases (54.0%), who also had the lowest prevalence of O (28.7%). There was a statistically significant better survival (P = 0.04) for blood group O cases than non‐O cases among unresected but not among resected patients. Secretor status did not show an association with PDAC or survival. Our study demonstrates that pancreatic cancer risk is influenced by ABO status, in particular blood groups O and A1, and that this association may reflect also in tumor resectability and survival.

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Section: Discussionmentioning

confidence: 99%

Associations between ABO blood groups and pancreatic ductal adenocarcinoma: influence on resection status and survival

et al. 2017

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“…The absence of both antigens results in the O phenotype. ABO blood group was found to be associated with numerous diseases and hemostatic complications such as increased risk of coronary artery disease and venous thromboembolism in patients with non-O blood type (8).…”

Section: Discussionmentioning

confidence: 99%

ABO Blood Types and Risk of Testicular Cancer in Turkish Population: Preliminary Results

Güner¹,

Güner²

2019

uob

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ABO blood type has been reported to be associated with various types of cancer such as lung cancer, prostate cancer, bladder cancer and pancreatic adenocarcinoma. We aimed to determine whether there is a relationship between ABO blood subtypes and testicular cancer incidence in Turkish population. Materials and Methods: We retrospectively analyzed the medical records of all patients who underwent inguinal orchiectomy in our department between 2008 and 2018. Results: A total of 138 patients were included in the study. The age of the patients ranged from two to 67 years, with a mean age of 32.9±10.9 years. Of the 138 participants, 45 (32.6%) had blood type A, 27 (19.6%) had blood type B, 50 had blood type O (36.2%) and 16 (11.6%) had blood type AB. One hundred and twenty-five patients (90.6%) were Rhesus (+) and 13 patients (9.4%) were Rhesus (-). There was no statistically significant difference between ABO blood subtypes according to testicular pathology (p=0.713). Interestingly, the percentage of patients with AB blood subtype was the lowest. Conclusion: These results suggest that Turkish men with O blood subtype and Rh (+) are prone to develop testicular cancer. However, these findings should be supported by further studies conducted with a large number of participants.

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“…(1993) показали, что среди пациентов с отрицательным резус-фактором наблюдаются менее тяжёлые стадии заболевания [10,11]. Ряд особенностей, описанных в подобных исследованиях, варьируют в разных странах [12][13][14][15][16]. Принимая во внимание факт неоднозначности имеющихся литературных данных, основной целью нашей работы стал анализ ассоциации между колоректальным раком и группами крови (по системе AB0 и по резус-фактору) в Южном Казахстане, как в самом многочисленном и наиболее густонаселённом регионе Республики.…”

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