The role of the immune system in hearing preservation after cochlear implantation

Verschuur, Carl; Causon, Andrew; Green, Kevin; Bruce, Iain; Agyemang-Prempeh, Akosua; Newman, Tracey

doi:10.1179/1467010014z.000000000233

Cited by 7 publications

(3 citation statements)

References 2 publications

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“…Inflammation and immune response are involved in the pathomechanism of many different forms of SNHLs. Excessive noise [155,156,157,237,248,252,272], ototoxic aminoglycoside antibiotics or cisplatin [256,269,273,274,275,276], aging [13,165,235,277,278,279], cochlear surgery and implantation [242,280,281] or hair cell ablation [238] all activate inflammation and immune response that are characterized by a massive infiltration of inflammatory cells into the cochlea. These studies also showed a correlation between the inflammation and the damage of the cochlea and impairment of hearing [14].…”

Section: Immune Mechanisms In Sensorineural Hearing Lossesmentioning

confidence: 99%

Purinergic Signaling and Cochlear Injury-Targeting the Immune System?

Köles

Szepesy

Berekméri

et al. 2019

IJMS

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Hearing impairment is the most common sensory deficit, affecting more than 400 million people worldwide. Sensorineural hearing losses currently lack any specific or efficient pharmacotherapy largely due to the insufficient knowledge of the pathomechanism. Purinergic signaling plays a substantial role in cochlear (patho)physiology. P2 (ionotropic P2X and the metabotropic P2Y) as well as adenosine receptors expressed on cochlear sensory and non-sensory cells are involved mostly in protective mechanisms of the cochlea. They are implicated in the sensitivity adjustment of the receptor cells by a K+ shunt and can attenuate the cochlear amplification by modifying cochlear micromechanics. Cochlear blood flow is also regulated by purines. Here, we propose to comprehend this field with the purine-immune interactions in the cochlea. The role of harmful immune mechanisms in sensorineural hearing losses has been emerging in the horizon of cochlear pathologies. In addition to decreasing hearing sensitivity and increasing cochlear blood supply, influencing the immune system can be the additional avenue for pharmacological targeting of purinergic signaling in the cochlea. Elucidating this complexity of purinergic effects on cochlear functions is necessary and it can result in development of new therapeutic approaches in hearing disabilities, especially in the noise-induced ones.

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Section: Immune Mechanisms In Sensorineural Hearing Lossesmentioning

confidence: 99%

Purinergic Signaling and Cochlear Injury-Targeting the Immune System?

Köles

Szepesy

Berekméri

et al. 2019

IJMS

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“…Acute damage to the cochlea occurs after a variety of pathological insults such as acoustic injury, ototoxicity, immune challenge and mechanical trauma due to cochlear implantation, all of which provoke inflammatory responses in the cochlea (Fujioka et al, 2006; Nakamoto et al., 2012; Tan et al, 2016; Verschuur et al, 2015; Wakabayashi et al, 2010 1869; Warchol et al, 2012). Cochlear inflammation caused by acute damage is characterized by a massive influx of inflammatory cells.…”

Section: Immune Cell Responses To Acute Cochlear Pathogenesismentioning

confidence: 99%

Immune cells and non-immune cells with immune function in mammalian cochleae

Zhang

Frye

2018

Hearing Research

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The cochlea has an immune environment dominated by macrophages under resting conditions. When stressed, circulating monocytes enter the cochlea. These immune mediators, along with cochlear resident cells, organize a complex defense response against pathological challenges. Since the cochlea has minimal exposure to pathogens, most inflammatory conditions in the cochlea are sterile. Although the immune response is initiated for the protection of the cochlea, off-target effects can cause collateral damage to cochlear cells. A better understanding of cochlear immune capacity and regulation would therefore lead to development of new therapeutic treatments. Over the past decade, there have been many advances in our understanding of cochlear immune capacity. In this review, we provide an update and overview of the cellular components of cochlear immune capacity with a focus on macrophages in mammalian cochleae. We describe the composition and distribution of immune cells in the cochlea and suggest that phenotypic and functional characteristics of macrophages have site-specific diversity. We also highlight the response of immune cells to acute and chronic stresses and comment on the potential function of immune cells in cochlear homeostasis and disease development. Finally, we briefly review potential roles for cochlear resident cells in immune activities of the cochlea.

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“…In recent years, there are increasing evidence that the inner ear immune response were involved in the acute injury of sensory epithelial cells caused by a variety of exogenous factors, including noise, ototoxic drugs, viral infection, cochlear implantation, and other injuries ( Fujioka et al, 2006 ; Warchol et al, 2012 ; Verschuur et al, 2015 ; Tan et al, 2016 ). The immune response of the cochlea is a sterile inflammatory response without the participation of pathogens, death of hair cells and secretion of pro-inflammatory factors are one of the main factors that trigger the recruitment and activation of cochlear immune cells.…”

Section: Macrophage Phenotype In Acute Cochlear Injurymentioning

confidence: 99%

Macrophage-related immune responses in inner ear: a potential therapeutic target for sensorineural hearing loss

Liu,

2024

Front. Neurosci.

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Hearing loss is the most common sensory disorder in human beings. Cochlear sensory cells are the basis of hearing. Cochlear sensory cells suffer from various acute or chronic injuries, such as excessive sound stimulation, ototoxic drugs, and age-related degeneration. In response to these stresses, the cochlea develops an immune response. In recent years, studies have shown that the immune response of the inner ear has been regarded as one of the important pathological mechanisms of inner ear injury. Therapeutic interventions for inflammatory responses can effectively alleviate different types of inner ear injury. As the main immune cells in the inner ear, macrophages are involved in the process of inner ear injury caused by various exogenous factors. However, its specific role in the immune response of the inner ear is still unclear. This review focuses on discusses the dynamic changes of macrophages during different types of inner ear injury, and clarifies the potential role of macrophage-related immune response in inner ear injury.

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The role of the immune system in hearing preservation after cochlear implantation

Cited by 7 publications

References 2 publications

Purinergic Signaling and Cochlear Injury-Targeting the Immune System?

Purinergic Signaling and Cochlear Injury-Targeting the Immune System?

Immune cells and non-immune cells with immune function in mammalian cochleae

Macrophage-related immune responses in inner ear: a potential therapeutic target for sensorineural hearing loss

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