The role of the medial nucleus of amygdala in the mating-induced enhancement of lordosis in female rats: the interaction with luteinizing hormone-releasing hormone neuronal system

Rajendren, Gopalan; Moss, Robert L.

doi:10.1016/0006-8993(93)90616-u

Cited by 63 publications

(36 citation statements)

References 21 publications

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“…Aspects of the perifornical region have been identified as projecting to such major sites of CRF-R2 expression as the lateral septal and ventromedial hypothalamic nuclei (32)(33)(34), and the sources of local inhibitory (GABAergic) projections to stress-related neuroendocrine and autonomic effectors in the paraventricular nucleus includes a rostral perifornical component (35) whose distribution is very similar to that of Ucn III-expressing neurons. With regard to the third major site of Ucn III expression identified in our material, anatomical and functional studies have indicated that medial nucleus of the amygdala projects extensively to the hypothalamus (including the ventromedial nucleus) and other limbic forebrain structures (36) and is involved in modulation of behaviors (37,38) and neuroendocrine function (39,40) related particularly to reproduction and stress. Overall, the central sites of Ucn III expression described here are consistent with potential roles for this peptide in modulating stress-related autonomic, neuroendocrine, and behavioral function, perhaps including some previously thought to be a province of other members of this peptide family.…”

Section: Discussionmentioning

confidence: 99%

Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor

Lewis

Perrin

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

882

718

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The corticotropin-releasing factor (CRF) family of neuropeptides includes the mammalian peptides CRF, urocortin, and urocortin II, as well as piscine urotensin I and frog sauvagine. The mammalian peptides signal through two G protein-coupled receptor types to modulate endocrine, autonomic, and behavioral responses to stress, as well as a range of peripheral (cardiovascular, gastrointestinal, and immune) activities. The three previously known ligands are differentially distributed anatomically and have distinct specificities for the two major receptor types. Here we describe the characterization of an additional CRF-related peptide, urocortin III, in the human and mouse. In searching the public human genome databases we found a partial expressed sequence tagged (EST) clone with significant sequence identity to mammalian and fish urocortin-related peptides. By using primers based on the human EST sequence, a full-length human clone was isolated from genomic DNA that encodes a protein that includes a predicted putative 38-aa peptide structurally related to other known family members. With a human probe, we then cloned the mouse ortholog from a genomic library. Human and mouse urocortin III share 90% identity in the 38-aa putative mature peptide. In the peptide coding region, both human and mouse urocortin III are 76% identical to pufferfish urocortin-related peptide and more distantly related to urocortin II, CRF, and urocortin from other mammalian species. Mouse urocortin III mRNA expression is found in areas of the brain including the hypothalamus, amygdala, and brainstem, but is not evident in the cerebellum, pituitary, or cerebral cortex; it is also expressed peripherally in small intestine and skin. Urocortin III is selective for type 2 CRF receptors and thus represents another potential endogenous ligand for these receptors.

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Section: Discussionmentioning

confidence: 99%

Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor

Lewis

Perrin

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

882

718

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“…Furthermore, a combined anterograde and retrograde tracing study on male Syrian hamsters (Coolen and Wood, 1998) has identified bidirectional connections between the posterodorsal subdivision of the medial amygdaloid nucleus and the AVPV. In considering the significance of medial amygdala projections in reproduction-associated functions, it should be noted that electrolytic lesions of the medial amygdala disrupt estrogen-dependent lordosis behavior and reduce mating-induced FOS expression in GnRH neurons (Rajendren and Moss, 1993). Furthermore, cytotoxic lesions at this site disinhibit maternal behavior in rats (Sheehan et al, 2001).…”

Section: Telencephalonmentioning

confidence: 99%

Comparative study of the sources of neuronal projections to the site of gonadotrophin-releasing hormone perikarya and to the anteroventral periventricular nucleus in female rats

Hahn

Coen

2005

J. Comp. Neurol.

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The rat ovulatory cycle is dependent on the preoptic region encompassing the gonadotrophin-releasing hormone (GnRH) perikarya and the anteroventral periventricular nucleus (AVPV). Retrograde tract tracing was used to identify and compare the sources of inputs to these sites in female rats. Within the telencephalon and diencephalon, the incidence of retrograde labelling from both sites was moderate to abundant in the ventral lateral septum, posteromedial bed nucleus of the stria terminalis, amygdalohippocampal area and the periventricular, medial preoptic, anterodorsal preoptic, dorsomedial suprachiasmatic, arcuate, and posterior ventrolateral ventromedial hypothalamic nuclei. In these regions, the incidence of retrograde labelling was either greater from the AVPV than from the GnRH perikarya site or similar from both sites. In the medial amygdaloid, parastrial, striohypothalamic, and ventral premammillary nuclei, the retrograde labelling from the AVPV greatly exceeded the sparse incidence from the GnRH perikarya site. In contrast, retrograde labelling from the GnRH perikarya site predominated in the median preoptic, lateroanterior and dorsomedial hypothalamic nuclei, subparaventricular zone, and retrochiasmatic area; it was abundant in the AVPV. Caudal to the diencephalon, retrograde labelling from either site was sparse, except in the lateral parabrachial nucleus, which displayed a particularly high incidence from the GnRH perikarya site. Other mesencephalic regions labelled from either site included the periaqueductal gray and dorsal and median raphe nuclei. The most caudal labelling was found in the ventrolateral medulla and region of the solitary tract nucleus; this was almost exclusively from the GnRH perikarya site. These findings further elucidate the neuroanatomical connections underlying the control of the ovulatory cycle.

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“…Together, these lines of evidence support the conclusion that the three subdivisions of the amygdala are engaged in related but distinctly different brain operations. The corticomedial division links the primary and accessory olfactory systems and other amygdaloid subdivisions (Scalia and Winans 1975) with neuroendocrine (Dunn and Whitener 1986;Kato et al 1986;Schulkin et al 1989;Rajendren and Moss 1993), sexual (Pfaff and Keiner 1973;Harris and Sachs 1975), and agonistic (Luiten et al 1985) response systems located in the medial hypothalamus. Extensive bidirectional connections with the brainstem together with extensive experimental evidence indicate that the central division of the amygdala has nociceptive, gustatory, and autonomic functions (Bernard et al 1996 and references therein).…”

Section: Introductionmentioning

confidence: 99%

“…The central division has been proposed as the efferent link for some stimulusresponse associations (LeDoux 1992(LeDoux , 1993aSavander et al 1995). Finally, there is evidence that the medial division has an important role in types of learning that regulate the expression of agonistic behavior (Luiten et al 1985;Vochteloo and Koolhaas 1987;Rajendren and Moss 1993).…”

Section: Introductionmentioning

confidence: 99%

Differential patterns of c-fos mRNA expression in amygdala during successive stages of odor discrimination learning.

Hess¹,

Gall²,

Granger³

et al. 1997

Learn. Mem.

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Expression of the activity-dependent gene c-los was used to assess relative levels of neuronal activation in the amygdala and related structures of rats at different stages of odor discrimination learning. In situ hybridization was used to evaluate c-los mRNA content within the amygdalar subdivisions, the bed nucleus of the stria terminalis, and the hippocampus. After initial exploration of the test apparatus, c-los mRNA levels were increased in the medial and, to lesser extent, basolateral subdivisions and remained low in the central division. The balance of amygdala to hippocampal labeling favored hippocampus.Rats engaged in familiar nose-poke responses had comparably elevated labeling in the medial and basolateral divisions and low labeling densities in the central division. The ratio of hippocampal to amygdala labeling was at control levels. Rats required to switch from ad libitum responding to cued responding to odors had high basolateral to medial labeling ratios. This was in marked contrast to the medial dominance found in control and exploration rats. Hybridization was substantially more dense in basolateral amygdala than in hippocampal CA1; this imbalance was unique to the group required to form first associations between odors and rewards. Rats performing an overtrained odor discrimination had the least differentiation between amygdalar subdivisions of any behavioral group. The 4Corresponding author.hippocampus-to-amygdala labeling ratio favored hippocampus and was nearly identical to the ratio in exploration rats. These results demonstrate that the balance of activity within and between limbic structures shifts according to behavioral demands. It is suggested that the balances reflect the availability of pertinent afferent cues, interactions between hippocampus and the extended amygdala, and relative levels of activity in the diffuse projections to the limbic system.

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The role of the medial nucleus of amygdala in the mating-induced enhancement of lordosis in female rats: the interaction with luteinizing hormone-releasing hormone neuronal system

Cited by 63 publications

References 21 publications

Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor

Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor

Comparative study of the sources of neuronal projections to the site of gonadotrophin-releasing hormone perikarya and to the anteroventral periventricular nucleus in female rats

Differential patterns of c-fos mRNA expression in amygdala during successive stages of odor discrimination learning.

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