The role of the melanocortin system and the melanocortin-4 receptor in ring dove (Streptopelia risoria) feeding behavior

Strader, April D.; Schiöth, Helgi B.; Buntin, John D.

doi:10.1016/s0006-8993(02)03799-x

Cited by 58 publications

(44 citation statements)

References 28 publications

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“…For chicken, nothing is known regarding the possibility of aversive effects of MT-II, but taking into account the inspected normal behavior of the treated chicks, the similarity of MT-II effects in the chicks with those following i.c.v. injection to ring dove (Strader et al 2003) and those reported in mammals, suggests that the MT-II effects on the broiler and layer chicks reported here are specific.…”

Section: Discussionsupporting

confidence: 66%

“…There is also a similarity between the expression profiles of chicken POMC and MCR genes and those of their mammalian homologs, although in chicken there is more pronounced expression in the peripheral tissues (Ottaviani et al 1997, Gerets et al 2000, Ling et al 2004. Intracerebroventricular injection of MC3/4R agonists in neonatal chicks or ringdoves has been shown to significantly inhibit food intake (Kawakami et al 2000, Tachibana et al 2001, Strader et al 2003, as well as neuropeptide Y-induced feeding when neuropeptide Y is given simultaneously (Kawakami et al 2000). However, this is the first report describing the effect of peripherally administered MC3/4R agonist on chickens, a comparison between the two commercial chicken strains representing obese and lean phenotypes, and a comparative analysis of POMC gene expression in the hypothalamus.…”

Section: Introductionmentioning

confidence: 96%

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The melanocortin circuit in obese and lean strains of chicks

Hen

Yosefi

Simchaev

et al. 2006

Journal of Endocrinology

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Agonists of membranal melanocortin 3 and 4 receptors (MC3/4Rs) are known to take part in the complex control mechanism of energy balance. In this study, we compared the physiological response to an exogenous MC3/4R agonist and the hypothalamic expression of proopic melanocortin (POMC) gene, encoding few MC3/4R ligands, between broiler and layer chicken strains. These strains, representing the two most prominent commercial strains of chickens grown for meat (broilers) and egg production (layers), differ in their food intake, fat accumulation, and reproductive performance and, therefore, form a good model of obese and lean phenotypes, respectively. A single i.v. injection of the synthetic peptide melanotan-II (MT-II; 1 mg/kg body weight) into the wing vein of feed-restricted birds led to attenuation of food intake upon exposure to feeding ad libitum in both broiler and layer chickens. A study of the POMC mRNA encoding the two prominent natural MC3/4R agonists, a-MSH and ACTH, also revealed a general similarity between the strains. Under feeding conditions ad libitum, POMC mRNA levels were highly similar in chicks of both strains and this level was significantly reduced upon feed restriction. However, POMC mRNA down-regulation upon feed restriction was more pronounced in layers than in broilers. These results suggest: (i) a role for MC3/4R agonists in the control of appetite; (ii) that the physiological differences between broilers and layers are not related to unresponsiveness of broiler chickens to the satiety signal of MC3/4R ligands. Therefore, these findings suggest that artificial activation of this circuit in broiler chicks could help to accommodate with their agricultural shortcomings of overeating, fattening, and impaired reproduction.

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Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 96%

The melanocortin circuit in obese and lean strains of chicks

Hen

Yosefi

Simchaev

et al. 2006

Journal of Endocrinology

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“…As in mammals, MC1R has a welldocumented role in avian pigmentation and this appears to be its sole function (Takeuchi et al 1996;Mundy 2005). MC4R and MC5R are both expressed in the brain as well as in several peripheral tissues and within the brain MC4R is involved in regulating feeding behavior (Takeuchi and Takahashi 1998;Strader et al 2003). Although AGRP has widespread expression in the chicken, its expression in the avian brain shows a clear relation to feeding behavior similar to that found in mammals (Boswell et al 2002).…”

mentioning

confidence: 95%

Characterization of Japanese Quail yellow as a Genomic Deletion Upstream of the Avian Homolog of the Mammalian ASIP (agouti) Gene

et al. 2008

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ASIP is an important pigmentation gene responsible for dorsoventral and hair-cycle-specific melaninbased color patterning in mammals. We report some of the first evidence that the avian ASIP gene has a role in pigmentation. We have characterized the genetic basis of the homozygous lethal Japanese quail yellow mutation as a .90-kb deletion upstream of ASIP. This deletion encompasses almost the entire coding sequence of two upstream loci, RALY and EIF2B, and places ASIP expression under control of the RALY promoter, leading to the presence of a novel transcript. ASIP mRNA expression was upregulated in many tissues in yellow compared to wild type but was not universal, and consistent differences were not observed among skins of yellow and wild-type quail. In a microarray analysis on developing feather buds, the locus with the largest downregulation in yellow quail was SLC24A5, implying that it is regulated by ASIP. Finally, we document the presence of ventral skin-specific isoforms of ASIP mRNA in both wild-type quails and chickens. Overall, there are remarkable similarities between yellow in quail and lethal yellow in mouse, which involve a deletion in a similar genomic position. The presence of ventral-specific ASIP expression in birds shows that this feature is conserved across vertebrates.

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“…Agouti-related protein (AgRP) is a neuropeptide physiologically implicated in regulating food intake, body weight, and energy homeostasis in mammals (Hahn et al 1998, Rossi et al 1998, Marsh et al 1999, Hagan et al 2000, Morton and Schwartz 2001 as well as in birds (Tachibana et al 2001, Phillips-Singh et al 2003, Strader and Buntin 2003, Strader et al 2003. It is expressed primarily in the hypothalamus and adrenal glands, with a lower level of expression occurring in peripheral tissues such as gonads, lung, muscle, and kidney (Ollmann et al 1997, Shutter et al 1997, Takeuchi et al 2000.…”

Section: Introductionmentioning

confidence: 99%

“…The avian homologue of the arcuate nucleus, the tuberal hypothalamus (infundibular neurones) , contains AgRP cells and/or NPY-producing cells in several avian species (Kuenzel and McMurtry 1988;Boswell et al 2002;Strader and Buntin 2001;Strader et al 2003;Esposito et al 2001). To date, AgRP immunoreactivity has been shown only in the tuberal and lateral hypothalamic regions of the ring dove Buntin 2001, Strader et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Expression of agouti-related protein (AgRP) in the hypothalamus and adrenal gland of the duck (Anas platyrhynchos)

et al. 2004

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The presence and distribution of agouti-related protein (AgRP) immunoreactivity were investigated in the hypothalamus and adrenal gland of the duck using immunohistochemistry and Western blot analysis. Expression of AgRP mRNA was also studied using reverse transcriptase polymerase chain reaction (RT-PCR). A partial coding sequence (cds) of the duck AgRP gene was identified. Western blot analysis showed the presence of an AgRP-like peptide having a molecular weight consistent with the number of predicted amino acids of the avian AgRP. In the hypothalamus, AgRP immunoreactivity was found in neurons of the nucleus infundibularis and in fibers projecting to the median eminence. In the adrenals, AgRP immunoreactivity was observed in medullary cells. These findings suggest that in the duck, AgRP may play a role in regulating energy homeostasis and adrenal endocrine functions.

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The role of the melanocortin system and the melanocortin-4 receptor in ring dove (Streptopelia risoria) feeding behavior

Cited by 58 publications

References 28 publications

The melanocortin circuit in obese and lean strains of chicks

The melanocortin circuit in obese and lean strains of chicks

Characterization of Japanese Quail yellow as a Genomic Deletion Upstream of the Avian Homolog of the Mammalian ASIP (agouti) Gene

Expression of agouti-related protein (AgRP) in the hypothalamus and adrenal gland of the duck (Anas platyrhynchos)

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