The role of the microbiome in kidney stone formation

Mehta, Mayank R.; Goldfarb, David S.; Nazzal, Lama

doi:10.1016/j.ijsu.2016.11.024

Cited by 95 publications

(58 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Urinary emergency and other chronic urinary tract symptoms have been associated with modification of bacterial components of urine (5,9,10). Patients who tend to have kidney stones seem to have different gut and urinary microbiota compared to that of healthy control patients (17). Difference in stone formation prevalence is also seen between vegetarians and meat eaters, which has been attributed to the difference in protein consumption but could result from different urinary microbiota (18).…”

Section: Human Urinary Microbiota and Clinical Microbiology Implicationsmentioning

confidence: 99%

Human Bacterial Repertoire of the Urinary Tract: a Potential Paradigm Shift

et al. 2019

View full text Add to dashboard Cite

The aim of this article is to review the human repertoire of bacteria in urine already described by culture and metagenomic techniques and published in the literature. Our study led us to compare this repertoire with other available human repertoires. We followed automatic and manual bibliographical methods and found 562 bacterial species reported in the literature as part of the human urinary microbiota. Of the 562 species, 322 were described only by culture, 101 by both culture and metagenomics, and 139 only by metagenomics. A total of 352 species (62.6%) have been associated with at least one case report of human infection, of which 225 (40.0%) have been described as causative agents of urinary tract infection. The urinary tract bacterial repertoire contains 21.4% of the known prokaryotic diversity associated with human beings (464 species in common), and it shares 23.6% species with the human gut microbiota (350 species in common, 62.3% of the urine species). The urinary repertoire shares a significant difference in aerointolerant species compared with those of the gut microbiota (100/562 [17.8%] and 505/1,484 [34.0%], respectively; P < 0.001; odds ratio [OR] = 9.0 [7.0 to 11.4]). Studies using high-throughput sequencing show a higher proportion of aerointolerant bacteria in urine (74/240 [30.8%]) than studies using culture techniques (40/423 [9.5%]). Most pathogenic bacteria are part of the commensal human urinary tract bacteria, and their pathogenicity may occur following any imbalance of this microbiota. The restoration of urinary tract health can occur following a fecal transplantation. The potential gut origin of the human bacterial microbiota has to be explored.

show abstract

Section: Human Urinary Microbiota and Clinical Microbiology Implicationsmentioning

confidence: 99%

Human Bacterial Repertoire of the Urinary Tract: a Potential Paradigm Shift

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Approximately 75% of all kidney stones are composed primarily of calcium oxalate, with hyperoxaluria considered to be a primary risk factor for this type of stones (Liebman & Al‐Wahsh, ). Recent studies have shown that bacterial degradation of oxalate in the intestine decreases oxalate absorption, and a reduction in the urinary oxalate level decreases the incidence of calcium oxalate stone formation (Mehta et al ., ; Zhao et al ., ). In addition, several studies proposed that Lactobacillus and Bifidobacterium species possess oxalate degrading activity and documented a significant reduction in urinary oxalate levels associated with probiotic administration in both animals and humans (Campieri et al ., ; Weese et al ., ; Lieske et al ., ; Murphy et al ., ; Okombo & Liebma, ).…”

Section: Introductionmentioning

confidence: 99%

The effects of inulin as a prebiotic supplement and the synbiotic interactions of probiotics to improve oxalate degrading activity

Darilmaz

Sönmez

Beyatlı

2018

Int J of Food Sci Tech

View full text Add to dashboard Cite

This paper examines the impact of inulin, Lactobacillus spp. (candidate probiotics), and synbiotic (inulin + Lactobacillus spp.) preparation on oxalate degrading activity and viability of Escherichia coli. In this study, the lowest viability of E. coli was recorded for the synbiotic treatments of Lactobacillus fermentum BP5 (59%) and IP5 (60%). The oxalate degrading activity of L. fermentum IP5 was 38.18 and 29.60% higher than the other strains after growth in 10 mM and 20 mM MRS-ox plus 5% inulin media, respectively. The mixture of three strains demonstrated higher oxalate degrading capacity than the individual strains and showed the same good growth rates (9.43 CFU mL À1 ) as individuals. The study concludes that the addition of prebiotics has a significant effect on probiotics; therefore, a combination of L. fermentum IP5 with inulin could be a viable probiotic-based functional food approach in administering oxalate metabolism and also treatment of E. coli-related infections. Effect of prebiotic on oxalate degradation D. € Onal Darilmaz et al. the MRS-ox plus 5% inulin were found significant (P < 0.05). b Control: MRS broth (pH 6.8) without inulin and E. coli ATCC 11105. c Refrence strains. d Mixed culture: Mixed culture consist of MP1, IP5 and YG7 strains. Effect of prebiotic on oxalate degradation D. € Onal Darilmaz et al. 125 a Values are means AE standard deviations from experimenst done in triplicate. Differences in MRS-ox and MRS-ox plus 5% inulin for degrading activity were found to be significant (P < 0.05). b Control: MRS (pH 6.8) (Without sodium oxalate and inulin). c Refrence strains. d Mixed culture: Mixed culture consist of MP1, IP5 and YG7 strains. Effect of prebiotic on oxalate degradation D. € Onal Darilmaz et al. to be significant (P < 0.05). b Control: MRS (pH 6.8) (Without sodium oxalate and inulin). c Refrence strains. d Mixed culture: Mixed culture consist of MP1, IP5 and YG7 strains. Effect of prebiotic on oxalate degradation D. € Onal Darilmaz et al. Effect of prebiotic on oxalate degradation D. € Onal Darilmaz et al.

show abstract

“…hypertension can cause an increase in calcium, a secretion gout increased uric acid secretion low fluid and fluid intake just makes a higher concentration of the urine and makes the urine more likely to crystallize acidic urine can make acidic substances crystallize and UTI with infection from urease positive bugs like Proteus [14] and Klebsiella can lead to pneumonia formation which can lead to the formation of history white stones.…”

Section: Discussionmentioning

confidence: 99%

The Role of Imaging in Diagnosis of Urolithiasis and Nephrolithiasis—A Literature Review Article

Gupta¹,

Li²,

Ji³

et al. 2019

View full text Add to dashboard Cite

Urolithiasis or nephrolithiasis is a common ailment in the emergency room. The clinical presentation of a kidney stone includes fever, nausea, vomiting, acute flank pain radiating to the groin or the back. The pain is often described as stabbing and there is tachycardia, with or without hematuria for the severe patient. For the triad for urinary or kidney stones, some people say they are fever, vomiting, and acute flank pain. So in acute setting analgesia is given with or without an antiemetic to prevent vomiting IV fluids administered carefully. Noncontrast computed tomography (CT) is the gold standard for diagnosis. Most of urinary stones get washouts spontaneously if it is less than 5 mm without any intervention. However, if intervention is required either it is done by elective or as soon as possible by the intervention. I mean surgical management and surgical management will depend on how big the kidney stone is in there as well as where the kidney stone is if it is within the ureter or within the actual kidney.

show abstract

The role of the microbiome in kidney stone formation

Cited by 95 publications

References 32 publications

Human Bacterial Repertoire of the Urinary Tract: a Potential Paradigm Shift

Human Bacterial Repertoire of the Urinary Tract: a Potential Paradigm Shift

The effects of inulin as a prebiotic supplement and the synbiotic interactions of probiotics to improve oxalate degrading activity

The Role of Imaging in Diagnosis of Urolithiasis and Nephrolithiasis—A Literature Review Article

Contact Info

Product

Resources

About