The role of the mLDL-induced activation of the complement system classical pathway and C3 expression stimulation in atherosclerosis

Drapkina, О. М.; Михайловна, Драпкина Оксана; Gegenava, B. B.; Борисович, Гегенава Бадри; Fomin, V V; Викторович, Фомин Виктор

doi:10.26442/terarkh2018904100-104

Cited by 2 publications

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“…Studies have shown that urinary sodium excretion is the decisive factor in carotid intima–media thickness, which is an indicator of atherosclerosis [ 55 ]. The classical pathway of complement activation is also related to atherosclerosis [ 56 ]. Copper and isotypic cysteine can interact to generate free radicals, thereby oxidizing LDL, which has been found in atherosclerotic plaques [ 57 ].…”

Section: Resultsmentioning

confidence: 99%

Changes to Urinary Proteome in High-Fat-Diet ApoE−/− Mice

et al. 2022

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Cardiovascular disease is currently the leading cause of death worldwide. Atherosclerosis is an important pathological basis of cardiovascular disease, and its early diagnosis is of great significance. Urine bears no need nor mechanism to be stable, so it accumulates many small changes and is therefore a good source of biomarkers in the early stages of disease. In this study, ApoE-/- mice were fed a high-fat diet for 5 months. Urine samples from the experimental group and control group (C57BL/6 mice fed a normal diet) were collected at seven time points. Proteomic analysis was used for comparison within the experimental group and for comparison between the experimental group and the control group. The results of the comparison within the experimental group showed a significant difference in the urinary proteome before and after a one-week high-fat diet, and several of the differential proteins have been reported to be associated with atherosclerosis and/or as biomarker candidates. The results of the comparison between the experimental group and the control group indicated that the biological processes enriched by the GO analysis of the differential proteins correspond to the progression of atherosclerosis. The differences in chemical modifications of urinary proteins have also been reported to be associated with the disease. This study demonstrates that urinary proteomics has the potential to sensitively monitor changes in the body and provides the possibility of identifying early biomarkers of atherosclerosis.

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Section: Resultsmentioning

confidence: 99%

Changes to Urinary Proteome in High-Fat-Diet ApoE−/− Mice

et al. 2022

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show abstract

“…Studies have shown that urinary sodium excretion is the decisive factor of carotid intima-media thickness, which is an indicator of atherosclerosis [53] . The classical pathway of complement activation is also related to atherosclerosis [54] . Copper and isotype cysteine can interact to generate free radicals, thereby oxidizing LDL, which has been found in atherosclerotic plaques [55] .…”

Section: Intergroup Controlmentioning

confidence: 99%

Section: Intergroup Controlmentioning

confidence: 99%

Changes of urinary proteome in high-fat dietApoE^-/-mice

Hua

Meng

Wei

et al. 2022

Preprint

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Cardiovascular disease is currently the leading cause of death worldwide. Atherosclerosis is an important pathological basis of cardiovascular disease, and its early diagnosis is of great significance. Urine is more conducive in the accumulation and response of changes in the physiological state of the body and is not regulated by homeostasis mechanisms, so it is a good source of biomarkers in the early stage of disease. In this study, ApoE-/- mice induced by a high-fat diet for 5 months were used to construct an animal model of atherosclerosis. Urine samples from the experimental group and control group, which were C57BL/6 mice fed a normal diet, were collected at seven time points. Proteomic analysis was used for internalcontrol and intergroup control. Internal control results showed a significant difference in the urinary proteome before and after a 1-week high-fat diet, and several differential proteins have been reported to be associated with atherosclerosis or for use as biomarkers. The results of the intergroup control indicated that the biological process enriched by the GO analysis of the differential proteins corresponded to disease progression. Differences in chemical modifications of urinary proteins have also been reported to be associated with the disease. This study demonstrates that urinary proteomics has the potential to monitor changes in the body sensitively and provides the possibility of identifying early biomarkers of atherosclerosis.

show abstract

The role of the mLDL-induced activation of the complement system classical pathway and C3 expression stimulation in atherosclerosis

Cited by 2 publications

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Changes to Urinary Proteome in High-Fat-Diet ApoE−/− Mice

Changes to Urinary Proteome in High-Fat-Diet ApoE−/− Mice

Changes of urinary proteome in high-fat dietApoE^-/-mice

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The role of the mLDL-induced activation of the complement system classical pathway and C3 expression stimulation in atherosclerosis

Cited by 2 publications

References 0 publications

Changes to Urinary Proteome in High-Fat-Diet ApoE−/− Mice

Changes to Urinary Proteome in High-Fat-Diet ApoE−/− Mice

Changes of urinary proteome in high-fat dietApoE-/-mice

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Changes of urinary proteome in high-fat dietApoE^-/-mice