The role of the natural aquatic environment in the dissemination of extended spectrum beta-lactamase and carbapenemase encoding genes: A scoping review

Hooban, Brigid; Joyce, Aoife; Fitzhenry, Kelly; Chique, Carlos; Morris, Dearbháile

doi:10.1016/j.watres.2020.115880

Cited by 66 publications

(45 citation statements)

References 65 publications

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“…latest test for the rapid detection of the five groups of CTX-M-producing Enterobacterales, as previously reported (Bernabeu et al, 2020). As observed in other studies, group 1 CTX-Mproducing E. coli isolates were dominant in our study (Zarfel et al, 2017;Hooban et al, 2020). As commonly found in CTX-M-producers, most isolates were multidrug resistant, possessing aminoglycoside-modifying enzyme [e.g., aac(6 )-Ib, aadA1, aadA5, or aph(3 )-Ia], quinolone-resistance genes (qnrS1), tetracycline (tetA, tetB), chloramphenicol (catB3), and trimethoprim/sulfamethoxazole (dfrA14, dfrA17, sul1, and sul2).…”

Section: Resistome Analysessupporting

confidence: 89%

“…However, it remains difficult to conclude on the original source of these isolates, which could be of avian/environmental or human sources. Hooban et al (2020) reported that most of the ESBL producers identified in aquatic environments around the world between 2010 and 2017 expressed bla CTX−M genes (n = 21 among 29 studies), followed by bla TEM (n = 18), and bla SHV (n = 11). Surprisingly, among eight Chinese studies, only three identified CTX-M-producing E. coli FIGURE 1 | Phylogenetic tree of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli from Seine River.…”

Section: Discussionmentioning

confidence: 99%

“…isolates in rivers and lakes (Hooban et al, 2020). The prevalence of ESBL producers among waterborne thermo-tolerant coliforms ranged in amount from 11% (Ye et al, 2017) to 17% in Chinese rivers (Chen et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

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Occurrence and Diversity of CTX-M-Producing Escherichia coli From the Seine River

Girlich

Bonnin

2020

Front. Microbiol.

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CTX-M-producing Escherichia coli are spreading since 1999 both in clinical and in community settings. Environmental samples such as rivers have also been pointed out as being vectors for ESBL producers. In this report, we have investigated the presence and the diversity of CTX-M-producing E. coli isolates in two samplings of the Seine River (next to Notre Dame), Paris France, performed in June 2016 and 2017. The total number of bacteria growing on the selective ChromID ESBL agar was 3.1 × 105 cfu/L (23.8% of all growing bacteria) in 2016, whereas it was 100-fold lower in 2017 (3 × 103 cfu/L; 8.3% of all growing bacteria). However, among them, the prevalence of ESBL-producing E. coli increased from <0.1 to 1.1% in one-year. ESBLs were exclusively of the CTX-M-type: CTX-M-1 (n = 5), CTX-M-15 (n = 7), CTX-M-14 (n = 1), and CTX-M-27 (n = 2). The isolates belonged to several multi locus sequence types, and a wide diversity of incompatibility groups of plasmids were identified in those E. coli isolates. The occurrence and diversity of E. coli isolates belonging to many clones and producing many CTX-M-variants have been identified in our study. The presence of these bacteria in rivers that are open again for recreational usage (swimming) is worrying as it may contribute to further dissemination of ESBL producers in the community.

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Section: Resistome Analysessupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Occurrence and Diversity of CTX-M-Producing Escherichia coli From the Seine River

Girlich

Bonnin

2020

Front. Microbiol.

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“…There are several ecological factors that explain the community transmission of ESBL-E. As mentioned before, George et al [ 26 ] found that the contact with open sewage drains and public toilets could explain ESBL-E foci at the community level. As geographic mapping can assist in hypothesis formulation, we think of two hypothesis: (i) the interaction between tertiary hospitals and the community and; (ii) nearby rivers can be a source of antimicrobial resistance in the community because, it has been mentioned that the natural aquatic environment can be a contributor to the development and circulation of antibiotic resistance genes [ 35 ]. Otun River is highlighted as it is used for recreational purposes and settlements of the poultry industry are near the river bank.…”

Section: Discussionmentioning

confidence: 99%

Geographic mapping of Enterobacteriaceae with extended-spectrum β-lactamase (ESBL) phenotype in Pereira, Colombia

et al. 2020

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Background Antimicrobial resistance is an ecological and multicausal problem. Infections caused by extended-spectrum β-lactamase producing Enterobacteriaceae (ESBL-E) can be acquired and transmitted in the community. Data on community-associated ESBL-E infections/colonizations in Colombia are scarce. Georeferencing tools can be used to study the dynamics of antimicrobial resistance at the community level. Methods We conducted a study of geographic mapping using modern tools based on geographic information systems (GIS). Two study centers from the city of Pereira, Colombia were involved. The records of patients who had ESBL-producing Enterobacteriaceae were reviewed. Antimicrobial susceptibility testing and phenotypic detection of ESBL was done according to CLSI standards. Results A population of 415 patients with community-acquired infections/colonizations and 77 hospital discharges were obtained. Geographic distribution was established and heat maps were created. Several hotspots were evidenced in some geographical areas of the south-west and north-east of the city. Many of the affected areas were near tertiary hospitals, rivers, and poultry industry areas. Conclusions There are foci of antimicrobial resistance at the community level. This was demonstrated in the case of antimicrobial resistance caused by ESBL in a city in Colombia. Causality with tertiary hospitals in the city, some rivers and the poultry industry is proposed as an explanation of the evidenced phenomenon. Geographic mapping tools are useful for monitoring antimicrobial resistance in the community.

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“…Point and nonpoint sources contribute to the presence and proliferation of AMR bacteria and ARGs in surface waters [9,[34][35][36]. Figure 1 shows the known sources of resistance contaminants and how they could potentially contribute to recreational water exposures to AMR bacteria and ARGs [34,36,73,82]. Feasible pathways of movement for AMR bacteria and ARGs vary for the different potential sources, depending on factors including, but not limited to, local regulations and industrial practices.…”

Section: Anthropogenic Sources Of Antibiotic Resistance In Recreationmentioning

confidence: 99%

Antibiotic Resistance in Recreational Waters: State of the Science

Nappier

Liguori

Ichida

et al. 2020

IJERPH

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Ambient recreational waters can act as both recipients and natural reservoirs for antimicrobial resistant (AMR) bacteria and antimicrobial resistant genes (ARGs), where they may persist and replicate. Contact with AMR bacteria and ARGs potentially puts recreators at risk, which can thus decrease their ability to fight infections. A variety of point and nonpoint sources, including contaminated wastewater effluents, runoff from animal feeding operations, and sewer overflow events, can contribute to environmental loading of AMR bacteria and ARGs. The overall goal of this article is to provide the state of the science related to recreational exposure and AMR, which has been an area of increasing interest. Specific objectives of the review include (1) a description of potential sources of antibiotics, AMR bacteria, and ARGs in recreational waters, as documented in the available literature; (2) a discussion of what is known about human recreational exposures to AMR bacteria and ARGs, using findings from health studies and exposure assessments; and (3) identification of knowledge gaps and future research needs. To better understand the dynamics related to AMR and associated recreational water risks, future research should focus on source contribution, fate and transport—across treatment and in the environment; human health risk assessment; and standardized methods.

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The role of the natural aquatic environment in the dissemination of extended spectrum beta-lactamase and carbapenemase encoding genes: A scoping review

Cited by 66 publications

References 65 publications

Occurrence and Diversity of CTX-M-Producing Escherichia coli From the Seine River

Occurrence and Diversity of CTX-M-Producing Escherichia coli From the Seine River

Geographic mapping of Enterobacteriaceae with extended-spectrum β-lactamase (ESBL) phenotype in Pereira, Colombia

Antibiotic Resistance in Recreational Waters: State of the Science

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