The Role of the Noradrenergic System in Autism Spectrum Disorders

Beversdorf, David Q.

doi:10.1007/978-1-4419-1272-5_11

Cited by 7 publications

(4 citation statements)

References 72 publications

(92 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, early in withdrawal, characterized by the highest degrees of anxiety (Aronson & Craig, 1986), there is a significant degree of impairment on language tasks and cognitive flexibility (Kelley et al, 2005), believed to be due to the apparent increased noradrenergic activation in chronic cocaine use and acute cocaine withdrawal (Macey et al, 2003; McDougle et al, 1994). Therefore, with neuropsychological findings potentially consistent with restricted network access in acute cocaine withdrawal (Beversdorf, 2010), as has been observed in autism (Frith & Happé, 1994; Beversdorf et al, 2000), we would predict decreased functional connectivity in acute cocaine withdrawal due to the cognitive impairments observed in this setting.…”

Section: Introductionsupporting

confidence: 58%

Functional connectivity during language processing in acute cocaine withdrawal: A pilot study

et al. 2012

Self Cite

View full text Add to dashboard Cite

Recent research revealed decreased access to semantic and associative networks in acute cocaine withdrawal. In autism, such behavioral outcomes are associated with decreased functional connectivity using functional magnetic resonance imaging. Therefore, we wished to determine whether connectivity is also decreased in acute cocaine withdrawal. Eight subjects in acute cocaine withdrawal were compared to controls for connectivity in language areas while performing a task involving categorization of words according to semantic and phonological relatedness. Acute withdrawal subjects had significantly less overall connectivity during semantic relatedness, and a trend towards less connectivity during phonological relatedness. Of potential future interest is whether this might serve as an imaging marker for treatment in patients.

show abstract

Section: Introductionsupporting

confidence: 58%

Functional connectivity during language processing in acute cocaine withdrawal: A pilot study

et al. 2012

Self Cite

View full text Add to dashboard Cite

show abstract

“…The genetic architecture of ASD has become increasingly clear and increasingly complex with estimates of at least 1000 genetic alterations associated with the risk for ASD [4]. In the last 10 years, there have been significant advances in understanding the genetic basis for ASD, critically supported through the establishment of ASD bio-collections and application in research.…”

Section: The Genetic Architecture Of Asdmentioning

confidence: 99%

“…Immunological imbalance (including autoimmunity) has been proposed as a major etiological component in ASD, taking into account increased levels of pro-inflammatory cytokines observed in postmortem brain from patients, as well as autoantibody production [1]. Evidence indicates an increased offspring vulnerability to ASD through advanced maternal and paternal age, valproate intake, toxic chemical exposure, maternal diabetes, enhanced steroidogenic activity, immune activation, and multifactorial [4]. An associations between early developmental exposure to ambient pesticides and autism spectrum disorder has been recently reported [5,6].…”

Section: Introductionmentioning

confidence: 99%

Autism Spectrum Disorder (ASD) in a Developing country. A Clinical and Descriptive Study of 75 Infant and Young Patients

Galindez

et al. 2019

BJSTR

View full text Add to dashboard Cite

Seventy five (75) infant patients, from 3-15 years old, clinically diagnosed with autism spectrum disorder exhibited disconnected brain with social isolation (80%), hyperconnected children (5%), creative child (Asperger syndrome) (10%), stereotyped movements of hands and body trunk (10%), hyperactivity and attention deficit (10%), language disorders such as delay in the onset of language or early vocalization, regressive changes of language, mutism, gestual language, escatologic language, digital language (5%), learning and memory deficit (10%), psychomotor delay (5%), behavioral changes, such as aggresivity and autoagressivity (10%), tactile hypersensitivity, crisis of cry (1%), separation anxiety (1%), mood disorders such as anxiety and depression (3%), photofobia (1%), loss of weight, (1%), routinised patterns of though and fantastic thoughts (2%).The following associated comorbidities: perinatal hypoxia, low weight at birth, behavioral abnormities, anxiety, auto-and heteroagressivity, hyperphagia, learning and hearing disorders, mainly hyperacusia, social isolation, cognitive deficit, sleeping disorders and parenteral abuse of child. Some non-nervous system comorbidities, such as allergic reaction, bronchial asthma and atopic dermatitis also were found. Some locomotor abnormalities as genus valgo and flat feet were also observed. The mothers exhibited some of the followings diseases during pregnancy: urinary infections, behavioral disturbances like anxiety, fobias, hyperactivity, toxoplasmosis and Zika virus infections, hyperemesis, oligohydramnios and lost of amniotic fluid, twin pregnancy, pre-eclampsia, aging placenta, cesarean surgery, high blood pressure, maternal sepsis, diabetes, hepatic coma, hypotiroidism, viral hepatitis, obesity, and social parenteral problems, such as excessive work, low economy and poor social conditions, environmental contamination and labor and conjugal stress.

show abstract

“…The strongest findings involve serotonin, blood concentrations of which are elevated in many autistic patients (Buitelaar and Willemsen-Swinkels, 2000). Other studies or hypotheses have implicated catecholamines (Beversdorf, 2010; Rylander, 1972; Yoo et al, 2009), amino acid transmitters (Fatemi et al, 2009; Purcell et al, 2001), and peptide transmitters (Bartz and Hollander, 2008). While many mechanisms may be involved, here we suggest that the neuromodulator adenosine could play a role in ameliorating neurological and behavioral sequelae of ASD.…”

Section: Introductionmentioning

confidence: 99%

Adenosine and autism: A spectrum of opportunities

et al. 2013

View full text Add to dashboard Cite

In rodents, insufficient adenosine produces behavioral and physiological symptoms consistent with several comorbidities of autism. In rodents and humans, stimuli postulated to increase adenosine can ameliorate these comorbidities. Because adenosine is a broad homeostatic regulator of cell function and nervous system activity, increasing adenosine’s influence might be a new therapeutic target for autism with multiple beneficial effects.

show abstract

The Role of the Noradrenergic System in Autism Spectrum Disorders

Cited by 7 publications

References 72 publications

Functional connectivity during language processing in acute cocaine withdrawal: A pilot study

Functional connectivity during language processing in acute cocaine withdrawal: A pilot study

Autism Spectrum Disorder (ASD) in a Developing country. A Clinical and Descriptive Study of 75 Infant and Young Patients

Adenosine and autism: A spectrum of opportunities

Contact Info

Product

Resources

About