AimTo discuss and provide examples of how nurse implementation scientists can support health system transformation.DesignDiscussion paper.MethodsUsing Prince Edward Island's health system strategic plan as a case exemplar, selected key priorities in the strategic plan were mapped with examples and discussion of how nurse implementation scientists can support health system transformation on Prince Edward Island and beyond.ConclusionAccelerating the development and delivery of evidence‐informed services that support health system transformation is needed. Nurse implementation scientists are ideally positioned to lead these efforts. Appropriate resourcing and compensation are essential to fully embrace nurse implementation scientist roles, collaboration, and buy‐in from health system leaders.Implications for NursingPractical examples of how nurse implementation scientists can lead health system transformation in a rigorous, evidence‐informed way are identified.ImpactLiterature providing examples of how nurse implementation scientists can make meaningful impacts within health systems, particularly in rural contexts, is limited. Nurse implementation scientists are ideally positioned to collaborate with and lead health system transformation by virtue of their knowledge, skills, qualifications and experience. Implications of this work extend beyond nursing to other health disciplines, health organisations, government leaders, researchers and populations. The discussion and examples provided may be applicable to similar contexts.Patient or Public ContributionNo patient or public contribution.